Implications of Diabetes Mellitus and Periodontal Disease

Hallmon, William W.; Mealey, Brian L.

doi:10.1177/014572179201800409

Cited by 24 publications

(19 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Inflammatory bone pathologies are often seen in individuals with T1D, including inflammatory arthritis and periodontitis-associated alveolar bone loss, where inflammatory mediators including bacterial components are abundant in these milieus (Hallmon and Mealey, 1992; Lalla et al, 2007; Mealey and Rose, 2008; Ryan et al, 2003; Somers et al, 2009; Teng, 2006). Thus, the effect of LPS on T1D-derived osteoclast function was evaluated.…”

Section: Resultsmentioning

confidence: 99%

Augmented LPS responsiveness in type 1 diabetes‐derived osteoclasts

Catalfamo

Calderon

Harden

et al. 2012

Journal Cellular Physiology

View full text Add to dashboard Cite

Bone abnormalities are frequent co-morbidities of type 1 diabetes [T1D] and are principally mediated by osteoblasts and osteoclasts which in turn are regulated by immunologic mediators. While decreased skeletal health in T1D involves alterations in osteoblast maturation and function, the affect of altered immune function on osteoclasts in T1D-associated bone and joint pathologies is less understood. Here T1D-associated osteoclast-specific differentiation and function in the presence and absence of inflammatory mediators was characterized utilizing bone marrow-derived osteoclasts [BM-OCs] isolated from non-obese diabetic [NOD] mice, a model for spontaneous autoimmune diabetes with pathology similar to individuals with T1D. Differentiation and osteoclast-mediated bone resorption were evaluated along with cathepsin K, MMP-9, and immune soluble mediator expression. The affect of LPS, a pro-inflammatory cytokine cocktail, and NOD-derived conditioned supernatants on BM-OC function was also determined. Although NOD BM-OCs cultures contained smaller osteoclasts, they resorbed more bone concomitant with increased cathepsin K, MMP-9 and pro-osteoclastogenic mediator expression. NOD BM-OCs also displayed an inhibition of LPS-induced deactivation that was not a result of soluble mediators produced by NOD BM-OCs, although a pro-inflammatory milieu did enhance NOD BM-OCs bone resorption. Together these data indicate that osteoclasts from a T1D mouse model hyper-respond to RANK-L resulting in excessive bone degradation via enhanced cathepsin K and MMP-9 secretion concomitant with an increased expression of pro-osteoclastic soluble mediators. Our data also suggest that inhibition of LPS-induced deactivation in NOD-derived BM-OC cultures is most likely due to NOD osteoclast responsiveness rather than LPS-induced expression of soluble mediators.

show abstract

Section: Resultsmentioning

confidence: 99%

Augmented LPS responsiveness in type 1 diabetes‐derived osteoclasts

Catalfamo

Calderon

Harden

et al. 2012

Journal Cellular Physiology

View full text Add to dashboard Cite

show abstract

“…Therefore, in such patients there is higher CAL and more severe periodontal diseases. Some studies have shown a higher rate of tooth decay in diabetic patients due to xerostomia and seepage of glucose into Gingival Cervicular Fluid (GCF) [7,24]. An increase in number of lost teeth in diabetic patients with xerostomia might be attributed to tooth mobility due to periodontal diseases and an increase in the incidence of tooth decay in such patients, which is consistent with the results of present study, indicating higher CAL and more lost teeth in patients with xerostomia.…”

Section: Discussionmentioning

confidence: 99%

Oral health-related quality of life in diabetic patients: comparison of the Persian version of Geriatric Oral Health Assessment Index and Oral Health Impact Profile: A descriptive-analytic study

Nikbin

Bayani

Jenabian

et al. 2014

J Diabetes Metab Disord

View full text Add to dashboard Cite

BackgroundDiabetes mellitus is one of the systemic disease which is show important oral manifestation and influence oral health. This study describes how diabetes mellitus affects oral health and oral health-related quality of life. The aim of this study was to evaluate the oral health and oral health-related quality of life of diabetic patients and compare the discriminative capability of Persian versions of two GOHAI and OHIP-14 questionnaires in these patients.MethodsA total of 350 patients with Type II diabetes mellitus, referring to the Diabetes Clinic, were selected and data were collected by GOHAI and OHIP-14 questionnaires completed by patients and clinical examinations. Oral health parameters (CAL,BI,GI,PLI,DMFT and xerostomia) were measured, also concurrent validity and conformity of two questionnaires were assessed. In order to test Discriminant analysis capabilities of two questionnaires, ADD and SC scores of questionnaires were divided into two parts and a logistic regression model was designed, which included subjective and objective variables.ResultsMean patients age was 55 years (with 75.4% female patients). The results showed that some oral conditions such as xerostomia, clinical attachment loss, number of missing teeth and plaque index were correlated to diabetes control level (HbA1c) and type of anti-diabetic medication. ADD and SC scores of two questionnaires were at high level. However, the effect of oral problems on decreasing OHRQoL was evident. Both questionnaires had acceptable concurrent validity and conformity. Moreover, there was a strong correlation between GOHAI and OHIP-14. OHIP-14 questionnaire had a higher discriminant analysis capability compared to GOHAI and better diagnosed patients who needed dental treatments: patients with higher GI, xerostomia and those wearing partial dentures.ConclusionDiabetic patients did not show acceptable oral health status and in some extent, oral problems affected oral health-related quality of life. Psychotherapy courses and solving oral problems of the patients can improve OHRQoL. OHIP-14 had higher discriminant analysis capability and was more effective in diagnosing oral problems.

show abstract

“…Frequent daily intake of refined carbohydrates may also contribute to a higher incidence of caries among people with diabetes [14]. Effective control of oral disease can be attained systemically through better glycemic control and locally through improved oral hygiene [15, 16]. …”

Section: Introductionmentioning

confidence: 99%

A survey of oral health education provided by certified diabetes educators

Yuen

Onicescu

Hill

et al. 2010

Diabetes Research and Clinical Practice

View full text Add to dashboard Cite

The purpose of this study was to investigate certified diabetes educators’ (CDEs) perceptions of the adequacy of their diabetes education curricula in providing oral health information. A questionnaire was mailed to all CDEs with a mailing address in South Carolina (SC), United States (US). Of the 130 respondents, almost all (93.8%) expressed that oral health should be part of the curriculum. However, the majority of them (76.9%) reported that their curricula did not include an oral health module; the two predominant reasons were: not having enough time (61.0%), and not knowing enough about oral health and its relationship to diabetes (37.0%). Respondents who expressed that they did not know enough about oral health and its relationship to diabetes were less likely to provide adequate oral-health-related information (p = 0.008), especially information about the effect of periodontal disease on diabetes (p = 0.016). This study indicates that SC CDEs do not routinely provide oral health education to people with diabetes primarily due to lack of time and knowledge related to oral health. To better serve their patients, CDEs should integrate oral health education in the diabetes education curriculum.

show abstract

Implications of Diabetes Mellitus and Periodontal Disease

Cited by 24 publications

References 50 publications

Augmented LPS responsiveness in type 1 diabetes‐derived osteoclasts

Augmented LPS responsiveness in type 1 diabetes‐derived osteoclasts

Oral health-related quality of life in diabetic patients: comparison of the Persian version of Geriatric Oral Health Assessment Index and Oral Health Impact Profile: A descriptive-analytic study

A survey of oral health education provided by certified diabetes educators

Contact Info

Product

Resources

About