Implications of Foraging and Interspecies Interactions of Birds for Carriage of Escherichia coli Strains Resistant to Critically Important Antimicrobials

Mukerji, S.; Gunasekera, Samantha; Dunlop, J. N.; Stegger, Marc; Jordan, David; Laird, Tanya; Abraham, Rebecca; Barton, Mary D.; O’Dea, Mark; Abraham, Sam

doi:10.1128/aem.01610-20

Cited by 25 publications

(14 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Palmgren et al (2006) ringed gulls and sampled 1,047 individuals for up to 3 years. This study failed to detect long-term carriage of antibiotic-resistant Salmonella since Papagiannitsis et al, 2017;Vergara et al, 2017;Vittecoq et al, 2017;Ahlstrom et al, 2018Ahlstrom et al, , 2019aBarguigua et al, 2019; atricilla Poeta et al, 2008;Bonnedahl et al, 2009Rose et al, 2009;Hernandez et al, 2010;Simões et al, 2010;Veldman et al, 2013;Hasan et al, 2014;Stedt et al, 2015;Alcalá et al, 2016;Aberkane et al, 2016Aberkane et al, , 2017Atterby et al, 2016Atterby et al, , 2017Dolejska et al, 2016;Liakopoulos et al, 2016;Merkeviciene et al, 2017Merkeviciene et al, , 2018Papagiannitsis et al, 2017;Troxler et al, 2017;Vergara et al, 2017;Ahlstrom et al, 2018Ahlstrom et al, , 2019aAhlstrom et al, ,b, 2021Mukerji et al, 2019Mukerji et al, , 2020 all positive individuals were negative during the sampling 2 months later.…”

Section: Evidence Of Gulls Acting As Reservoirs Of Arb or Argsmentioning

confidence: 82%

The Role of Gulls as Reservoirs of Antibiotic Resistance in Aquatic Environments: A Scoping Review

et al. 2021

View full text Add to dashboard Cite

The role of wildlife with long-range dispersal such as gulls in the global dissemination of antimicrobial resistance (AMR) across natural and anthropogenic aquatic environments remains poorly understood. Antibiotic-resistant bacteria have been detected in resident and migratory gulls worldwide for more than a decade, suggesting gulls as either sentinels of AMR pollution from anthropogenic sources or independent reservoirs that could maintain and disperse AMR across aquatic environments. However, confirming either of these roles remains challenging and incomplete. In this review, we present current knowledge on the geographic regions where AMR has been detected in gulls, the molecular characterization of resistance genes, and the evidence supporting the capacity of gulls to disperse AMR across regions or countries. We identify several limitations of current research to assess the role of gulls in the spread of AMR including most studies not identifying the source of AMR, few studies comparing bacteria isolated in gulls with other wild or domestic species, and almost no study performing longitudinal sampling over a large period of time to assess the maintenance and dispersion of AMR by gulls within and across regions. We suggest future research required to confirm the role of gulls in the global dispersion of AMR including the standardization of sampling protocols, longitudinal sampling using advanced satellite tracking, and whole-genome sequencing typing. Finally, we discuss the public health implications of the spread of AMR by gulls and potential solutions to limit its spread in aquatic environments.

show abstract

Section: Evidence Of Gulls Acting As Reservoirs Of Arb or Argsmentioning

confidence: 82%

The Role of Gulls as Reservoirs of Antibiotic Resistance in Aquatic Environments: A Scoping Review

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Importantly, clinically healthy homing pigeons have served as an unnoticed reservoir for zoonotic bacteria that are spread Antibiotics 2021, 10, 777 2 of 9 by faeces [8]. Furthermore, the close relationships between humans and birds have contributed to the spread of infectious agents, including antibiotic-resistant bacteria [9], and are an epidemiological link to wild birds [8]. The global and clonal multidrug-resistant carbapenem-resistant Enterobacteriaceae (CRE) carried by pigeons therefore may be established in ecological niches that include humans, livestock, wildlife, pets, and insects [10].…”

Section: Introductionmentioning

confidence: 99%

Molecular Epidemiology of Fosfomycin Resistant E. coli from a Pigeon Farm in China

Han

Liu

et al. 2021

Antibiotics

View full text Add to dashboard Cite

We determined the prevalence and molecular characteristics of fosfomycin-resistant Escherichia coli from a domestic pigeon farm. A total of 79 samples collected from pigeons and their surrounding environments were screened for the presence of fosfomycin resistant isolates and these included 49 E. coli isolates that displayed high-level resistance (MIC ≥ 256 mg L−1) and carried the fosA3 gene on plasmids with sizes ranging from 80 to 370 kb. MLST analysis of these fosA3-positive E. coli isolates indicated the presence of nine sequence types (ST6856, ST8804, ST457, ST746, ST533, ST165, ST2614, ST362 and ST8805) of which ST6856 was the most prevalent (24.5%, 12/49). PFGE combined with genomic context comparative analyses indicated that the fosA3 gene was spread by horizontal transfer as well as via clonal transmission between E. coli in the pigeon farm, and IS26 played an important role in fosA3 transmission. The high prevalence of fosA3 in the pigeon farm and the high similarity of the fosA3 genomic environment between E. coli isolates from humans and pigeons indicated that the pigeon farm served as a potential reservoir for human infections. The pigeon farm was found to be an important reservoir for the fosA3 gene and this should be further monitored.

show abstract

“…4 The potential role of seagulls as a wildlife vector for the spread of antimicrobial resistance (AMR) was further substantiated by an investigation towards the transmission of resistant E. coli strains and associated mobile genetic elements (MGE) between different species of wild birds (including seagulls) sharing a coastal habitat adjacent to an urban environment. 5 The study found a significantly higher frequency of CIA-R E. coli in seagulls (53%) compared to penguins (11%) and pigeons (10%) with no CIA-R E. coli found in Bridled Terns.…”

Section: Introductionmentioning

confidence: 77%

Proximity to human settlement is directly related to carriage of critically important antimicrobial-resistant Escherichia coli and Klebsiella pneumoniae in Silver Gulls

Mukerji

Sahibzada

Abraham

et al. 2021

Preprint

Self Cite

View full text Add to dashboard Cite

Human population and activities play an important role in dissemination of antimicrobial resistant bacteria. This study investigated the relationship between carriage rates of critically important antimicrobial-resistant (CIA-R) Escherichia coli and Klebsiella pneumoniae by Silver Gulls and their proximity to human populations. Faecal swabs (n=229) were collected from Silver Gulls across 10 southern coastline locations in Western Australia (WA). The sampling locations included main town centres and remote areas. Fluoroquinolone and extended-spectrum cephalosporin-resistant E. coli and K. pneumoniae were isolated and tested for antimicrobial sensitivity. Genome sequencing was performed to validate phenotypic resistance profiles and determine the molecular characteristics of strains. CIA-R E. coli and K. pneumoniae were detected in 69 (30.1%) and 20 (8.73%) of the faecal swabs respectively. Two large urban locations tested positive for CIA-R E. coli (frequency ranging from 34.3%-84.3%), and/or for CIA-R K. pneumoniae (frequency ranging from 12.5%-50.0%). A small number of CIA-R E. coli (3/31, 9.7%) were identified at a small tourist town, but no CIA-R bacteria were recovered from gulls at remote sites. Commonly detected E. coli sequence types (STs) included ST131 (12.5%) and ST1193 (10.0%), and five K. pneumoniae STs were found. Resistance genes including blaCTX-M-3, blaCTX-M-15 and blaCTX-M-27 were identified in both bacterial species. High-level colonisation of CIA-R E. coli and K. pneumoniae in Silver Gulls in and around urban areas compared to remote locations substantiates that anthropogenic activities are strongly associated with acquisition of resistant bacteria by gulls.

show abstract

Implications of Foraging and Interspecies Interactions of Birds for Carriage of Escherichia coli Strains Resistant to Critically Important Antimicrobials

Cited by 25 publications

References 34 publications

The Role of Gulls as Reservoirs of Antibiotic Resistance in Aquatic Environments: A Scoping Review

The Role of Gulls as Reservoirs of Antibiotic Resistance in Aquatic Environments: A Scoping Review

Molecular Epidemiology of Fosfomycin Resistant E. coli from a Pigeon Farm in China

Proximity to human settlement is directly related to carriage of critically important antimicrobial-resistant Escherichia coli and Klebsiella pneumoniae in Silver Gulls

Contact Info

Product

Resources

About