Implications of Gut-Brain axis in the pathogenesis of Psychiatric disorders

Taniguchi, Kurumi; Ikeda, Yuka; Nagase, Nozomi; Tsuji, Akira; Matsuda, Satoru

doi:10.3934/bioeng.2021021

Cited by 8 publications

(5 citation statements)

References 107 publications

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“…Dysbiosis can thus result in disruption of this axis and, in this way, contribute to the pathogenesis of various neuropsychiatric disorders. There is strong evidence from animal studies and increasing evidence in human studies supporting this hypothesis [ 71 , 72 ].…”

Section: The Microbiome and Neurological Disordersmentioning

confidence: 99%

Food for thought: Making the case for food produced via regenerative agriculture in the battle against non-communicable chronic diseases (NCDs)

Ramkumar,

Marty,

Ramkumar

et al. 2024

One Health

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Section: The Microbiome and Neurological Disordersmentioning

confidence: 99%

Food for thought: Making the case for food produced via regenerative agriculture in the battle against non-communicable chronic diseases (NCDs)

Ramkumar,

Marty,

Ramkumar

et al. 2024

One Health

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“…Accordingly, a dietary approach could adjust the gut microbiota that are potentially advantageous for the treatment of neurodegenerative disorders [ 116 ]. These gut microbiota might also inhibit the production of ROS, in order to maintain the health of the host brain [ 117 ]. It might be significant to reduce the levels of ROS for the improvement of neuro-regeneration with neuronal stem cells [ 118 , 119 ].…”

Section: Future Perspectivesmentioning

confidence: 99%

The Tryptophan and Kynurenine Pathway Involved in the Development of Immune-Related Diseases

Tsuji

Ikeda

Yoshikawa

et al. 2023

IJMS

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The tryptophan and kynurenine pathway is well-known to play an important role in nervous, endocrine, and immune systems, as well as in the development of inflammatory diseases. It has been documented that some kynurenine metabolites are considered to have anti-oxidative, anti-inflammatory, and/or neuroprotective properties. Importantly, many of these kynurenine metabolites may possess immune-regulatory properties that could alleviate the inflammation response. The abnormal activation of the tryptophan and kynurenine pathway might be involved in the pathophysiological process of various immune-related diseases, such as inflammatory bowel disease, cardiovascular disease, osteoporosis, and/or polycystic ovary syndrome. Interestingly, kynurenine metabolites may be involved in the brain memory system and/or intricate immunity via the modulation of glial function. In the further deliberation of this concept with engram, the roles of gut microbiota could lead to the development of remarkable treatments for the prevention of and/or the therapeutics for various intractable immune-related diseases.

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“…It is well recognized that gut microbiota are the most significant regulator of the gut–brain axis [ 61 ]. The alteration of the composition of the gut microbiome could lead to schizophrenia.…”

Section: Involvement Of Gut–brain Axis Via the Production Of D-amino ...mentioning

confidence: 99%

D-Amino Acids as a Biomarker in Schizophrenia

et al. 2022

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D-amino acids may play key roles for specific physiological functions in different organs including the brain. Importantly, D-amino acids have been detected in several neurological disorders such as schizophrenia, amyotrophic lateral sclerosis, and age-related disorders, reflecting the disease conditions. Relationships between D-amino acids and neurophysiology may involve the significant contribution of D-Serine or D-Aspartate to the synaptic function, including neurotransmission and synaptic plasticity. Gut-microbiota could play important roles in the brain-function, since bacteria in the gut provide a significant contribution to the host pool of D-amino acids. In addition, the alteration of the composition of the gut microbiota might lead to schizophrenia. Furthermore, D-amino acids are known as a physiologically active substance, constituting useful biomarkers of several brain disorders including schizophrenia. In this review, we wish to provide an outline of the roles of D-amino acids in brain health and neuropsychiatric disorders with a focus on schizophrenia, which may shed light on some of the superior diagnoses and/or treatments of schizophrenia.

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Implications of Gut-Brain axis in the pathogenesis of Psychiatric disorders

Cited by 8 publications

References 107 publications

Food for thought: Making the case for food produced via regenerative agriculture in the battle against non-communicable chronic diseases (NCDs)

Food for thought: Making the case for food produced via regenerative agriculture in the battle against non-communicable chronic diseases (NCDs)

The Tryptophan and Kynurenine Pathway Involved in the Development of Immune-Related Diseases

D-Amino Acids as a Biomarker in Schizophrenia

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