Implications of Habitual Alcohol Intake With the Prognostic Significance of Mean Corpuscular Volume in Stage II-III Colorectal Cancer

Abstract

ObjectiveTo elucidate the prognostic significance of mean corpuscular volume (MCV), with implications of habitual alcohol intake in stage II-III colorectal cancer (CRC).BackgroundMCV had the potential to become an ideal prognostic biomarker and be put into clinical application. Few studies, however, have explored whether habitual alcohol intake which greatly increased the value of MCV would affect the prognostic role of MCV.MethodsEligible patients were identified from the CRC database of Fudan University Shanghai Cancer Center (FUSCC) between January 2012 and December 2013. Survival analyses were constructed using the Kaplan–Meier method to evaluate the survival time distribution, and the log-rank test was used to determine the survival differences. Univariate and multivariate Cox proportional hazard models were built to calculate the hazard ratios of different prognostic factors.ResultsA total of 694 patients diagnosed with stage II-III CRC between January 2012 and December 2013 were identified from FUSCC. Low pretreatment MCV was independently associated with 72.0% increased risk of overall mortality compared with normal MCV (HR = 1.720, 95%CI =1.028-2.876, P =0.039, using normal MCV as the reference). In patients with habitual alcohol intake, however, pretreatment MCV positively correlated with the mortality (P = 0.02) and tumor recurrence (P = 0.002) after adjusting for other known prognostic factors.ConclusionsIn CRC patients without habitual alcohol intake, low (<80 fL) level of pretreatment MCV was a predictor of poor prognosis. In patients with habitual alcohol intake, however, pretreatment MCV showed the opposite prognostic role, which would elicit many fundamental studies to elucidate the mechanisms behind.

Clinical significance of mean corpuscular volume as a prognostic indicator of radiotherapy for locally advanced lung cancer: a retrospective cohort study

“…Those with high MCV levels before treatment had significantly shorter OS than those with low MCV levels. Similarly, we found that both T and N stages were negatively correlated with OS, which concurred with the results of previous studies ( 6 - 10 , 17 , 18 ).…”

“…Except for being used to assist in the diagnosis of hematological diseases, MCV has been reported as clinically associated with tumors such as head and neck tumors, esophageal cancer, colorectal cancer, liver cancer, etc. and a high MCV is a poor predictor of long-term survival in patients with solid tumors (6)(7)(8)(9)(10)17,18).…”

Genetic Alterations of SMYD4 in Solid Tumors Using Integrative Multi-Platform Analysis

“…In general, SMYD4 negatively weak correlates with other SMYD genes. For instance, SMYD3 is known to be upregulated in colorectal cancers [ 24 , 25 , 26 , 27 ]. In patients with high expression of SMYD3 , SMYD4 is consistently downregulated, exhibiting a clear negative correlation.…”

Mean Corpuscular Volume as a Prognostic Factor for Patients With Habitual Alcohol or Tobacco Use After Esophagectomy

“…Preoperative malnutrition has been reported to be a predictor of outcomes in cancer patients and can be used as a prognostic indicator (15-17). Recently, MCV has been found to be another nutrition parameter correlated with the survival of various solid malignancies (3)(4)(5)(6)(7)(8). Previous studies showed that elevated MCV was always observed in patients with malnutrition due to alcohol abuse (3).…”

“…Elevated MCV is always associated with deficiency of folate and vitamin B12, which may be seen in patients with a history of gastrectomy, malnutrition due to alcohol abuse, and so on (3). Recently, MCV was found to be correlated with the survival of patients with several malignancies, such as liver cancer, gastroesophageal adenocarcinomas, colorectal cancer, and head and neck cancer (3)(4)(5)(6)(7)(8).…”