Implications of Intracellular Distribution of Nanovesicles for Bioimaging Studies

Elbayoumi, Tamer; Weissig,

doi:10.1166/jbn.2009.1079

Cited by 9 publications

(4 citation statements)

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“…The advancement of mitochondrial targeted liposomes is largely attributed to the research group of Dr. Volkmar Weissig (Boddapati et al, 2008; Boddapati et al, 2010; Boddapati et al, 2005; D’Souza et al, 2005; Elbayoumi and Weissig, 2009; Patel et al, 2010). In the development of an anti-tumor drug, Boddapati et al fabricated stearyl triphenyl phosphonium (STPP) functionalized liposomes for ceramide to specifically target the mitochondria (Boddapati et al, 2008).…”

Section: 0 Nano-therapeuticsmentioning

confidence: 99%

Functionalized nanosystems for targeted mitochondrial delivery

Durazo

Kompella

2012

Mitochondrion

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Mitochondrial dysfunction including oxidative stress and DNA mutations underlies the pathology of various diseases including Alzheimer’s disease and diabetes, necessitating the development of mitochondria targeted therapeutic agents. Nanotechnology offers unique tools and materials to target therapeutic agents to mitochondria. As discussed in this paper, a variety of functionalized nanosystems including polymeric and metallic nanoparticles as well as liposomes are more effective than plain drug and non-functionalized nanosystems in delivering therapeutic agents to mitochondria. Although the field is in its infancy, studies to date suggest the superior therapeutic activity of functionalized nanosystems for treating mitochondrial defects.

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Section: 0 Nano-therapeuticsmentioning

confidence: 99%

Functionalized nanosystems for targeted mitochondrial delivery

Durazo

Kompella

2012

Mitochondrion

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“…Generally, in sensing platforms peptides are advantageous to use as they 1) are stable and robust in a myriad of environments, 2) can be easily synthesized, 3) are cost and time efficient, 4) can be easily modified to recognize a target, 5) are well characterized and 6) have been shown to easily immobilized to various surface platform materials (metals, plastics, fabrics, tissue sample). The ability to immobilize peptides to various platforms and targets has resulted in an upsurge in the development of [69][70][71][72][73] peptides constructed from a fusion of functional peptides, also known as bifunctional peptides. There are many examples in the literature of fusion peptides being used in biomimetic sensors in many areas of research (defense, medical, hazard detection, and environmental studies).…”

Section: Peptide-based Sensingmentioning

confidence: 99%

The development of Army relevant peptide-based surface enhanced Raman scattering (SERS) sensors for biological threat detection

et al. 2016

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The utility of peptide-based molecular sensing for the development of novel biosensors has resulted in a significant increase in their development and usage for sensing targets like chemical, biological, energetic and toxic materials. Using peptides as a molecular recognition element is particularly advantageous because there are several mature peptide synthesis protocols that already exist, peptide structures can be tailored, selected and manipulated to be highly discerning towards desired targets, peptides can be modified to be very stable in a host of environments and stable under many different conditions, and through the development of bifunctionalized peptides can be synthesized to also bind onto desired sensing platforms (various metal materials, glass, etc.). Two examples of the several Army relevant biological targets for peptide-based sensing platforms include Ricin and Abrin. Ricin and Abrin are alarming threats because both can be weaponized and there is no antidote for exposure. Combining the sensitivity of SERS with the selectivity of a bifunctional peptide allows for the emergence of dynamic hazard sensor for Army application.

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“…The ability to immobilize peptides to various platforms and targets has resulted in an upsurge in the development of peptides constructed from a fusion of functional peptides. (41)(42)(43)(44)(45) There are numerous examples in the literature of peptides targeted specifically for the recognition of the PA binder from anthrax, see Table 2 for examples. By combining the threat recognition capabilities of a peptide onto a biomimetic sensor platform, target specific detection is possible.…”

Section: Introductionmentioning

confidence: 99%

Army relevant Biological Hazards Detection with Commercial SERS substrates

Farrell

Pellegrino

2012

SPIE Proceedings

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There is an increasing need and challenge for early rapid and accurate detection, identification, and quantification of chemical, biological, and energetic hazards in many fields of interest (e.g., medical, environmental, industrial, and defense applications). Increasingly to meet these challenges, researchers are turning to interdisciplinary approaches combining spectroscopy with nanoscale platforms to create technologies that offer viable and novel solutions for today's sensing needs. One technology that has gained increasing popularity to meet these needs is surface enhanced Raman scattering (SERS). SERS is particularly advantageous as it does not suffer from interferences from water, requires little to no sample preparation, is robust and can be used in numerous environments, is relatively insensitive to the wavelength of excitation employed and produces a narrow-band spectral signature unique to the molecular vibrations of the analyte. SERS enhancements (chemical and electromagnetic) are typically observed on metalized nanoscale roughened surfaces. For ideal SERS sensing, a commercially available uniform and reproducible nanoscale surface demonstrating high sensitivity are desirable. Additionally, if these surfaces can be modified for the selective sensing of hazard materials, an ideal sensor platform for dynamic in field measurements can be imagined. In this proceedings paper, preliminary efforts towards the characterization and application of commercially available next generation Klarite substrates will be demonstrated. Additionally, efforts toward chemical modification of these substrates, through peptide recognition elements, can be used for the targeted sensing of hazardous materials.

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Implications of Intracellular Distribution of Nanovesicles for Bioimaging Studies

Cited by 9 publications

References 0 publications

Functionalized nanosystems for targeted mitochondrial delivery

Functionalized nanosystems for targeted mitochondrial delivery

The development of Army relevant peptide-based surface enhanced Raman scattering (SERS) sensors for biological threat detection

Army relevant Biological Hazards Detection with Commercial SERS substrates

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