Implications of obstructive sleep apnea in lung adenocarcinoma: A valuable omission in cancer prognosis and immunotherapy

Qi, Pengju; Qi, Bo; Ding, Yuan; Sun, Jianxia; Li, Zhuoshi; Huo, Shuhua; Liu, Yuzhen; Zhao, Baosheng

doi:10.1016/j.sleep.2023.05.013

Cited by 3 publications

(1 citation statement)

References 43 publications

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“…Patients in Cluster 2 had a poor response to immunotherapy, which could be attributed to T cell depletion because of the chronic inflammatory response associated with long-term IH. In contrast, those in Cluster 3 could maximize the benefits of treatment with immune checkpoint inhibitors ( 101 ). This finding provides a new biomarker for predicting lung adenocarcinoma prognosis, although the model requires external validation.…”

Section: Pathogenesismentioning

confidence: 99%

A review of obstructive sleep apnea and lung cancer: epidemiology, pathogenesis, and therapeutic options

Yuan,

Hu,

et al. 2024

Front. Immunol.

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Despite undeniable advances in modern medicine, lung cancer still has high morbidity and mortality rates. Lung cancer is preventable and treatable, and it is important to identify new risk factors for lung cancer, especially those that can be treated or reversed. Obstructive sleep apnea (OSA) is a very common sleep-breathing disorder that is grossly underestimated in clinical practice. It can cause, exacerbate, and worsen adverse outcomes, including death and various diseases, but its relationship with lung cancer is unclear. A possible causal relationship between OSA and the onset and progression of lung cancer has been established biologically. The pathophysiological processes associated with OSA, such as sleep fragmentation, intermittent hypoxia, and increased sympathetic nervous excitation, may affect normal neuroendocrine regulation, impair immune function (especially innate and cellular immunity), and ultimately contribute to the occurrence of lung cancer, accelerate progression, and induce treatment resistance. OSA may be a contributor to but a preventable cause of the progression of lung cancer. However, whether this effect exists independently of other risk factors is unclear. Therefore, by reviewing the literature on the epidemiology, pathogenesis, and treatment of lung cancer and OSA, we hope to understand the relationships between the two and promote the interdisciplinary exchange of ideas between basic medicine, clinical medicine, respiratory medicine, sleep medicine, and oncology.

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Section: Pathogenesismentioning

confidence: 99%

A review of obstructive sleep apnea and lung cancer: epidemiology, pathogenesis, and therapeutic options

Yuan,

Hu,

et al. 2024

Front. Immunol.

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Burden of obstructive sleep apnea in patients with lung cancer and its effect on performance status

Zidan,

Shaarawy,

Gharraf

et al. 2024

Journal of Sleep Research

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SummaryThe association between lung cancer and obstructive sleep apnea has remained a matter of debate for years. Obstructive sleep apnea is thought to increase the incidence of lung cancer due to intermittent hypoxaemia and sleep fragmentation. The aim of this study is to assess the prevalence of obstructive sleep apnea in patients with lung cancer and its effect on those patients' performance status. This is a prevalence study that was conducted at Chest Diseases Department, Alexandria Main University Hospitals. We enrolled 153 patients with lung cancer. All patients underwent cardiorespiratory monitoring using a home sleep‐testing device. Performance status was assessed using Karnofsky performance status scale. The study included 120 (78.4%) males and 33 (21.6%) females newly diagnosed with lung cancer. The mean age was 59.98 ± 11.11 years. Obstructive sleep apnea (apnea–hypopnea index ≥ 5) was present in 134 (87.6%) patients. Eighty‐five (63.4%) patients had mild obstructive sleep apnea, 39 (29.1%) patients had moderate obstructive sleep apnea, and 10 (7.46%) patients had severe obstructive sleep apnea. Prolonged nocturnal oxygen desaturation as demonstrated by time of oxygen saturation spent below 90% (T90%) during total sleep time > 30% was present in 25 (16.3%) patients. There was a significant difference in the median value of Karnofsky performance status scale between patients with lung cancer and associated obstructive sleep apnea and those without obstructive sleep apnea. In conclusion, obstructive sleep apnea is highly prevalent among patients with lung cancer. Performance status is worse among patients with lung cancer in the presence of obstructive sleep apnea. Screening patients with lung cancer for obstructive sleep apnea is important regardless of the presence of classical symptoms of obstructive sleep apnea.

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Identification and Mendelian randomization validation of pathogenic gene biomarkers in obstructive sleep apnea

Gong,

Tuo,

Liu

2024

Front. Neurol.

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BackgroundBy 2020, obstructive sleep apnea (OSA), a prevalent respiratory disorder, had affected 26.6–43.2% of males and 8.7–27.8% of females worldwide. OSA is associated with conditions such as hypertension, diabetes, and tumor progression; however, the precise underlying pathways remain elusive. This study aims to identify genetic markers and molecular mechanisms of OSA to improve understanding and treatment strategies.MethodsThe GSE135917 dataset related to OSA was obtained from the GEO database. Differentially expressed genes (DEGs) were subsequently identified. Weighted gene co-expression network analysis (WGCNA) was conducted to pinpoint disease-associated genes. The intersection of these data enabled the identification of potential diagnostic DEGs. Further analyses included Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment studies, exploration of protein–protein interactions based on these genes, and an examination of immune infiltration. Mendelian randomization was employed to validate core genes against the Genome-Wide Association Study database.ResultsA total of 194 DEGs were identified in this study. WGCNA network analysis highlighted 2,502 DEGs associated with OSA. By intersecting these datasets, 53 diagnostic DEGs primarily involved in metabolic pathways were identified. Significant alterations were observed in immune cell populations, including memory B cells, plasma cells, naive CD4 T cells, M0 macrophages, and activated dendritic cells. CETN3, EEF1E1, PMM2, GTF2A2, and RRM2 emerged as hub genes implicated in the pathogenesis. A line graph model provides diagnostic insights. Mendelian randomization analysis confirmed a causal link between CETN3 and GTF2A2 with OSA.ConclusionThrough WGCNA, this analysis uncovered significant genetic foundations of OSA, identifying 2,502 DEGs and 194 genes associated with the disorder. Among these, CETN3 and GTF2A2 were found to have causal relationships with OSA.

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Implications of obstructive sleep apnea in lung adenocarcinoma: A valuable omission in cancer prognosis and immunotherapy

Cited by 3 publications

References 43 publications

A review of obstructive sleep apnea and lung cancer: epidemiology, pathogenesis, and therapeutic options

A review of obstructive sleep apnea and lung cancer: epidemiology, pathogenesis, and therapeutic options

Burden of obstructive sleep apnea in patients with lung cancer and its effect on performance status

Identification and Mendelian randomization validation of pathogenic gene biomarkers in obstructive sleep apnea

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