Implications of phytochemicals as disease-modifying agents against Huntington's disease (HD): Bioactivity, animal models and transgenics, synergism and structure–activity studies

A promising discovery of an anti-aging chemical conjugate derived from lipoic acid and sesamol established inDrosophila melanogaster

“…74 Apart from lifespan expansion, antioxidant therapy prevents post-oxidative stress disorders such as Alzheimer's disease (AD), multiple sclerosis, Parkinson's disease, depression, memory loss, etc. 75,76 Also, reports are available in the literature on early detection of oxidative stress biomarkers and controlling their overproduction. 72,77 Still, no report is available on the combination of lipoic acid with sesamol linked via a chemical bond for longevity expansion in the Drosophila melanogaster model.…”

Metabolic Reprogramming and Cancer: 2022

“…The TGF β signaling is also linked to cancer metabolism and EMT [118]. Nanoparticle-coated α-mangostin (α-Mangostin, a natural xanthonoid found in bark and dried sap of Garcinia mangostana L.) could inhibit colorectal cancer growth and EMT by downregulating GSK3β/β-catenin /CDK6 signaling pathway [119][120][121]. Curcumin obtained from turmeric and analogues of curcumin modulated signaling network, miRNAs and EMT and anticancerous effect on colorectal cancer stem cells [122].…”