Implications of racial/ethnic perinatal health inequities on long-term neurodevelopmental outcomes and health services utilization

Fraiman, Yarden S.; Barrero-Castillero, Alejandra; Litt, Jonathan S.

doi:10.1016/j.semperi.2022.151660

Cited by 13 publications

(2 citation statements)

References 82 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this cohort, home age and ethnic minority status were associated with increased odds of NDD at 18 months. Prior research has shown that racial/ethnic minorities face health inequities that portend poorer long-term neurodevelopmental outcomes [ 29 ]. This may result from limited English proficiency, systemic racial bias within healthcare, or socioeconomic disadvantages [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

Infant Saliva Microbiome Activity Modulates Nutritional Impacts on Neurodevelopment

Keck-Kester,

Hicks

2023

Microorganisms

View full text Add to dashboard Cite

Neurodevelopment is influenced by complex interactions between environmental factors, including social determinants of health (SDOH), nutrition, and even the microbiome. This longitudinal cohort study of 142 infants tested the hypothesis that microbial activity modulates the effects of nutrition on neurodevelopment. Salivary microbiome activity was measured at 6 months using RNA sequencing. Infant nutrition was assessed longitudinally with the Infant Feeding Practices survey. The primary outcome was presence/absence of neurodevelopmental delay (NDD) at 18 months on the Survey of Wellbeing in Young Children. A logistic regression model employing two microbial factors, one nutritional factor, and two SDOH accounted for 33.3% of the variance between neurodevelopmental groups (p < 0.001, AIC = 77.7). NDD was associated with Hispanic ethnicity (OR 18.1, 2.36–139.3; p = 0.003), no fish consumption (OR 10.6, 2.0–54.1; p = 0.003), and increased Candidatus Gracilibacteria activity (OR 1.43, 1.00–2.07; p = 0.007). Home built after 1977 (OR 0.02, 0.001–0.53; p = 0.004) and Chlorobi activity (OR 0.76, 0.62–0.93, p = 0.001) were associated with reduced risk of NDD. Microbial alpha diversity modulated the effect of fish consumption on NDD (X2 = 5.7, p = 0.017). These data suggest the benefits of fish consumption for neurodevelopment may be mediated by microbial diversity. Confirmation in a larger, randomized trial is required.

show abstract

Section: Discussionmentioning

confidence: 99%

Infant Saliva Microbiome Activity Modulates Nutritional Impacts on Neurodevelopment

Keck-Kester,

Hicks

2023

Microorganisms

View full text Add to dashboard Cite

show abstract

“…Once born, infants born to Black birthing people experience lower-quality neonatal care and have an increased risk of adverse outcomes [49][50][51][52][53][54][55][56]. These include a higher risk for sepsis, necrotizing enterocolitis, intraventricular hemorrhage, and bronchopulmonary dysplasia, all of which are associated with worse neurodevelopmental outcomes for preterm-born children and may contribute to inequities across the pediatric life-course [57][58][59][60][61][62][63].…”

Section: Layered Inequity In Preterm Birth and Along The "Adhd Care C...mentioning

confidence: 99%

A Narrative Review of the Association between Prematurity and Attention-Deficit/Hyperactivity Disorder and Accompanying Inequities across the Life-Course

Fraiman,

Guyol,

Acevedo-Garcia

et al. 2023

Children

Self Cite

View full text Add to dashboard Cite

Preterm birth is associated with an increased risk of neurodevelopmental and neurobehavioral impairments including attention-deficit/hyperactivity disorder (ADHD), the most common neurobehavioral disorder of childhood. In this narrative review, we examine the known associations between prematurity and ADHD and highlight the impact of both prematurity and ADHD on multiple domains across the pediatric life-course. We develop a framework for understanding the health services journey of individuals with ADHD to access appropriate services and treatments for ADHD, the “ADHD Care Cascade”. We then discuss the many racial and ethnic inequities that affect the risk of preterm birth as well as the steps along the “ADHD Care Cascade”. By using a life-course approach, we highlight the ways in which inequities are layered over time to magnify the neurodevelopmental impact of preterm birth on the most vulnerable children across the life-course.

show abstract

Preterm Birth and Caregiver Employment Decisions

Von Klein,

Parker,

Patrick

et al. 2024

JAMA Pediatr

View full text Add to dashboard Cite

show abstract

Implications of racial/ethnic perinatal health inequities on long-term neurodevelopmental outcomes and health services utilization

Cited by 13 publications

References 82 publications

Infant Saliva Microbiome Activity Modulates Nutritional Impacts on Neurodevelopment

Infant Saliva Microbiome Activity Modulates Nutritional Impacts on Neurodevelopment

A Narrative Review of the Association between Prematurity and Attention-Deficit/Hyperactivity Disorder and Accompanying Inequities across the Life-Course

Preterm Birth and Caregiver Employment Decisions

Contact Info

Product

Resources

About