W ork dominates most people's adult lives; we spend far more of our time working than in any activity other than sleep. Accordingly, work is a major influence on health. In the United States, the Bureau of Labor Statistics (2020) reported that 5,333 workers experienced fatal occupational injuries in 2019, the highest number since 2007. Additionally, tens of thousands more workers die each year from occupational illnesses, and millions more experience nonfatal injuries serious enough to miss at least a day of work. In addition to threatening physical health, work also has a massive influence on mental health. For example, in the annual Stress in America surveys of the American Psychological Association (APA), work has been among participants' top sources of stress for over a decade (APA, 2017). These occupational health threats affect employers' productivity and profitability (Mitchell & Bates, 2011).These figures highlight the importance of occupational health as a concern for career psychology. Occupational health psychology (OHP) has emerged as a scientific discipline that focuses on the relationship between work and employee health with the goal of developing theories about the psychological mechanisms that influence employee health as well as implementing interventions that result in safer and healthier workplaces. Our chapter has three goals. First, we provide a brief overview of OHP and describe the concept of work organization as described by the National Institute for Occupational Safety and Health (NIOSH). Next, we present the job demands-resources (JD-R) model as a broad theoretical framework for thinking about how the workplace influences