Implications of the Regulation of Endothelial Glycocalyx Breakdown and Reconstitution in Severe Burn Injury

Basas, Vincent A.; Schutzman, Linda M.; Brown, Ian E.

doi:10.1016/j.jss.2022.12.033

Cited by 4 publications

(3 citation statements)

References 32 publications

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“… 71 In severe burns, platelets may accumulate and cause complications because of vascular endothelial damage in multiple organs. 72 , 73 , 74 …”

Section: Kinetics Of Blood Cells Following Burn Injurymentioning

confidence: 99%

“…In severe burns, a systemic inflammatory response is elicited that causes vascular endothelial damage. 72 , 73 , 74 Endothelial cells form a barrier that controls permeability and plays a central role in the distribution of water, cells, and molecules from the circulation to the tissues, and they have a central role at the forefront of defense against danger signals in the innate immune response. 75 DAMPs activate PRRs expressed on endothelial cell surfaces, 76 immune cells, tissue macrophages, and monocytes to induce the initiation of inflammatory and coagulation cascades.…”

Section: Burns and Vascular Endothelial Damagementioning

confidence: 99%

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Systemic immune response of burns from the acute to chronic phase

Osuka,

Shigeno,

Matsuura

et al. 2024

Acute Medicine & Surgery

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Immune responses that occur following burn injury comprise a series of reactions that are activated in response to damaged autologous tissues, followed by removal of damaged tissues and foreign pathogens such as invading bacteria, and tissue repair. These immune responses are considered to be programmed in living organisms. Developments of modern medicine have led to the saving of burned patients who could not be cured previously; however, the programmed response is no longer able to keep up, and various problems have arisen. This paper describes the mechanism of immune response specific to burn injury and the emerging concept of persistent inflammation, immunosuppression, and catabolism syndrome.

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“… 71 In severe burns, platelets may accumulate and cause complications because of vascular endothelial damage in multiple organs. 72 , 73 , 74 …”

Section: Kinetics Of Blood Cells Following Burn Injurymentioning

confidence: 99%

Section: Burns and Vascular Endothelial Damagementioning

confidence: 99%

Systemic immune response of burns from the acute to chronic phase

Osuka,

Shigeno,

Matsuura

et al. 2024

Acute Medicine & Surgery

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“…Fresh frozen plasma (FFP) has been shown to decrease endotheliopathy in burn and trauma patients [26]. Several recent publications have suggested that FFP improves outcomes after burn injury [27,28,29 ▪▪ ]. FFP is not without side effects, such as transfusion reaction, infectious disease transmission, and transfusion related fluid overload.…”

Section: Burn Resuscitation: Fluid Administrationmentioning

confidence: 99%

Acute care for burn patients: fluids, surgery, and what else?

Palmieri

2023

Current Opinion in Critical Care

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Purpose Recently published initiatives spanning the burn care spectrum have substantially changed the standard of care in burn care. The purpose of this article is to describe new impactful concepts in burn first aid, triage, resuscitation, and treatment as well as their impact on future research. Recent findings First aid after burn injury traditionally consists of extinguishing the burn and applying dressings. Recent evidence suggests that applying 20 min of cool tap water to the burn wound in the first 3 h postburn mitigates burn injury extent. National burn center transfer criteria have been updated, impacting patient initial transfer and management. The adverse effects of hydroxocobalamin, a commonly used antidote for cyanide toxicity, have been delineated. Initial burn resuscitation recommendations for both volume and potentially fluid type are being reexamined. The emergence of innovative skin substitutes may improve burn survival by providing a physiologically stabilizing intermediate dressing. Finally, formal clinical practice guidelines for early mobility in the ICU after burn injury have been defined. Summary These changes in burn care, triage, resuscitation, and treatment have challenged traditional burn care standards, created new standards, and are the basis for future prospective randomized trials.

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