This work deals with the notch sensitivity of sharp notches under multi-axial fatigue loading. The main discussion concerns the differences in notch sensitivity at high cycle fatigue regime, between tensile, torsional and combined loading. For this comparison, this paper considers a large set of fatigue experimental tests and several computing simulations analyzed with several notch theories for predicting fatigue life of a component. The considered experimental data, taken from literature, deal with the fatigue behavior of cast iron circumferentially V-notched specimens under tension, torsion, and combined loading mode. This paper tries to apply several techniques for theoretical strength assessment and to compare different procedures. The examined procedures need the computation of many parameters, focusing on the importance of using the tensile resistance to set these parameters or using both tensile and torsion resistances. However, the improvements obtained by means of the more complex procedures are not noteworthy, compared to the overall scatter. In author's opinion, the differences in notch sensitivity under tensile and torsional loading remain questionable.