Importance de la voie vagale sensitive : recherche d'une technique de déafférentation sélective chez le porc et le mouton

Darcy, Béatrice; Falempin, Maurice; Laplace, J.P.; Rousseau, Jean-Paul; Germain, C.; Rousseau, Alexandre Fontaine; Villiers, P. A.

doi:10.1051/rnd:19790626

Cited by 7 publications

(7 citation statements)

References 4 publications

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“…In the worldwide circle of pig partial [50] or total [99]. It allowed us to evidence the importance and general significance of sensory afferent information.…”

Section: Resultsmentioning

confidence: 99%

Forty years of achievement in french research on digestive physiology in the pig

Laplace¹,

Aumaı̂tre²,

Rérat³

2001

Reprod. Nutr. Dev.

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-The contribution of the research group set up by Rérat in the early 1960s in Jouy-en-Josas, and then expanded to Rennes, is summarised. As digestive processes are a major key to the nutritional status of monogastric animals, original methodologies based on advanced experimental surgery were developed in the pig to quantify the digestion and absorption yield, to know their factors of variation, and to understand their physiological and nutritional consequences. The group also extended its expertise to the control of food intake, the role of the nervous system and regulatory peptides, and several biomedical gut-related topics. pig / digestion / absorption / neurohumoral regulation / adaptationRésumé -Réalisations et succès de la recherche française : quarante ans de physiologie digestive chez le porc. Dès le début des années 60, un groupe de recherches a été constitué à l'initiative de A. Rérat à Jouy-en-Josas pour étudier divers aspects de la physiologie digestive chez le porc. Leur exploration a fourni des clés essentielles pour la maîtrise du statut nutritionnel chez cette espèce monogastrique, et un instrument d'amélioration de la production porcine. Ce groupe s'est élargi au fil des années et a même essaimé dans les années 80, notamment à Rennes. Il a apporté une contribution essentielle par le développement de méthodologies nouvelles généralement basées sur une chirurgie expérimentale très élaborée. Ces approches ont fourni de nombreux travaux originaux qui ont permis de décrire les processus de digestion (motricité, transit, sécrétions, hydrolyses enzymatiques

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“…In the worldwide circle of pig partial [50] or total [99]. It allowed us to evidence the importance and general significance of sensory afferent information.…”

Section: Resultsmentioning

confidence: 99%

Forty years of achievement in french research on digestive physiology in the pig

Laplace¹,

Aumaı̂tre²,

Rérat³

2001

Reprod. Nutr. Dev.

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“…In the late 1970s and early 80s, Darcy et al [24,25] described a method by which to selectively separate the efferent and afferent fibres in the porcine vagus nerve in vivo. We previously developed a model with centrally (insulin hypoglycaemia) induced stimulation of antral motility [19].…”

Section: Introductionmentioning

confidence: 99%

Inhibitory effect of GLP-1 on gastric motility persists after vagal deafferentation in pigs

Nagell

Wettergren

Ørskov

et al. 2006

Scandinavian Journal of Gastroenterology

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“…The surgical isolation of the vagal afferents at the level of the nodose ganglion as previously performed in cats (Mei & Dussardier, 1966) and in guinea-pig (Rech, 1966) is possible in sheep 5-6 months old, but division of both ganglia, leaving the bundles of motor fibres intact, led to acute oedema of lungs and immediate death of the sheep. Therefore, vagal deafferentation has been achieved by sectioning, mostly in the thorax, one vagus nerve together with sectioning the nodose ganglion on the other side Darcy et al 1979). The whole oesophagus was still innervated by efferents from one vagus nerve and either the whole thoracic oesophagus or its last 10-15 cm was presumed to be deafferented, according to the level of the vagotomy (cervical or thoracic).…”

Section: Discussionmentioning

confidence: 99%

“…The surgical isolation of the vagal sensory fibres at the level ofthe nodose ganglion in sheep and in pigs has previously been described (Darcy, Falempin, Laplace & Rousseau, 1979) and a brief report of some of these experiments has already been published (Falempin, Madhloum & Rousseau, 1983).…”

Section: Introductionmentioning

confidence: 99%

Effects of vagal deafferentation on oesophageal motility and transit in the sheep.

Falempin¹,

Madhloum²,

Rousseau³

1986

The Journal of Physiology

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SUMMARY1. Effects of vagal deafferentation on oesophageal motility and transit were studied in conscious sheep by recording the electromyographic activity of different parts of oesophagus during swallowing of saliva, or balloons inflated with 20 ml of air.2. Surgical isolation and subsequent sectioning of the nodose ganglion, leaving the bundle of motor fibres intact, can be performed in sheep. Division of both ganglia led to immediate death of sheep. However, vagal deafferentation of the thoracic oesophagus could be achieved by sectioning the thoracic vagus nerve in association with suctioning the contralateral nodose ganglion.3. The sectioning of one vagus nerve did not affect primary oesophageal peristalsis during swallowing of saliva or of a bolus. Balloons inflated in the pharyngeal cavity and left free to move caudally, failed to pass into the stomach within the normal time of 2-2-3 s in only 4-16 % of the tests. In these cases, they were always stopped in the thoracic oesophagus.4. Following total deafferentation of the thoracic oesophagus, balloons were prevented from being propelled into the stomach in each test. They were stopped for several minutes at the beginning of the deafferented part of the oesophagus. Electromyographic activity recorded from the deafferented part was reduced during swallowing of balloons or saliva.5. Deafferentation was confirmed by the failure of the presumed deafferented segment of oesophagus to respond to distension.6. These experiments provide direct evidence that the vagus carries information from the oesophagus which influences the central pattern generator during swallowing of a bolus or saliva. In sheep, this feed-back is essential for the effective swallowing of a bolus although not for saliva.

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Importance de la voie vagale sensitive : recherche d'une technique de déafférentation sélective chez le porc et le mouton

Cited by 7 publications

References 4 publications

Forty years of achievement in french research on digestive physiology in the pig

Forty years of achievement in french research on digestive physiology in the pig

Inhibitory effect of GLP-1 on gastric motility persists after vagal deafferentation in pigs

Effects of vagal deafferentation on oesophageal motility and transit in the sheep.

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