Importance of a functional measure in the evaluation of patients in a memory clinic: Validation of the Serbian version of the Amsterdam instrumental activities of daily living questionnaire

Milošević, Vuk; Malobabić, Marina; Stojanović, Ivana; Bašić, Jelena

doi:10.1016/j.clineuro.2022.107165

Cited by 5 publications

(5 citation statements)

References 31 publications

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“…The study involved 36 patients diagnosed with probable dementia due to AD at the Neurology Clinic, University Clinical Center Niš, based on the NIA-AA guidelines [6]. Patients underwent neurological examination and cognitive function assessments, including Mini-Mental State Examination (MMSE), Addenbrooke's Cognitive Examination Revised (ACE-R), Clinical Dementia Rating (CDR), and Instrumental activities of daily living (IADL) using the recently validated Serbian version of the Amsterdam IADL questionnaire (A-IADL-Q) [10,11]. Brain MRI was performed according to dementia protocol.…”

Section: Methodsmentioning

confidence: 99%

The INFLUENCE OF THE APOEε4 ALLELE ON PRO-INFLAMMATORY CYTOKINE LEVELS IN THE CEREBROSPINAL FLUID OF PATIENTS WITH ALZHEIMER’S DISEASE

Bašić,

Milošević,

Đorđević

et al. 2024

FU Med Biol

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Single nucleotide polymorphisms (SNPs) rs429358 and rs7412, the most commonly investigated variants in the apolipoprotein E gene (APOE) are crucial for APOEε4 carrier status determination. However, their association with inflammatory cytokine levels in patients with dementia due to Alzheimer’s disease (AD) remains unclear. This study aimed to investigate the influence of the APOEε4 allele on pro-inflammatory cytokine levels in the cerebrospinal fluid of patients with AD dementia. The research was conducted on 36 patients with probable dementia due to AD. APOE rs429358 and rs7412 were analyzed using the Real-Time PCR method with allele-specific TaqMan assays, followed by the analysis of APOEε4 allele carrier status. Patients carrying at least one APOEε4 allele were assigned as APOEε4+. Core biomarkers (Aβ42/40 ratio, t-Tau, p-Tau levels), as well as pro-inflammatory cytokine (Tumor necrosis factor-a (TNF-a) and interleukin-1b (IL-1b)) levels, were determined in the patient’s cerebrospinal fluid (CSF) using Enzyme-linked Immunosorbent Assay (ELISA). Seventeen patients (47.22%) were assigned as APOEε4+. CSF TNF-α levels were significantly higher in APOEε4+ AD dementia patients in comparison to APOEε4- patients (p<0.001), while no significant differences in IL-1b levels between these two groups were obtained. Correlation analysis showed that TNF-α negatively correlated with the Aβ42/40 ratio (p=0.033), while positive correlation with t-Tau and p-Tau was observed (p=0.001, p=0.015, respectively). These findings highlight the potential significance of TNF-α in the context of APOEε4 positivity and its implications in AD pathology.

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Section: Methodsmentioning

confidence: 99%

The INFLUENCE OF THE APOEε4 ALLELE ON PRO-INFLAMMATORY CYTOKINE LEVELS IN THE CEREBROSPINAL FLUID OF PATIENTS WITH ALZHEIMER’S DISEASE

Bašić,

Milošević,

Đorđević

et al. 2024

FU Med Biol

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“…A-IADL-Q [6,8] was completed by informers (close friends or relatives) of patients using the Qualtrics online platform (www.qualtrics.com). The A-IADL-Q short form consists of 30 items, and each item has a 5-point scale response option.…”

Section: Methodsmentioning

confidence: 99%

“…A-IADL-Q has been translated into and adapted for 31 languages, including Serbian [7]. The Serbian version of the short form of A-IADL-Q is a reliable and valid measure of IADL in patients with dementia and mild cognitive impairment, as shown in our previous study [8]. A-IADL-Q was administered using the Qualtrics online platform.…”

Section: Introductionmentioning

confidence: 94%

“…This study is an extension of our previously published research [8], where we performed a reliability analysis (by assessing internal consistency and reproducibility) and evaluated the construction validity of the Serbian version of A-IADL-Q. The present study aims to assess the diagnostic accuracy of the Serbian version of the Amsterdam IADL Questionnaire as a screening tool for dementia and to determine the cutoffs with the best combination of sensitivity and specificity.…”

Section: Introductionmentioning

confidence: 98%

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Assessment of the Instrumental Activities of Daily Living in Mild Cognitive Impairment and Dementia Due to Alzheimer's Disease: Diagnostic Accuracy of the Serbian Version of the Amsterdam Iadl Questionnaire

et al. 2023

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To establish a diagnosis of dementia, it is necessary, in addition to cognitive impairment, to prove the existence of a disorder of instrumental activities of daily living (IADL). The Amsterdam IADL Questionnaire is a reliable instrument translated into different languages. This study aims to assess the diagnostic accuracy of the Serbian version of the Amsterdam IADL Questionnaire. The study included 75 patients with mild cognitive impairment (MCI) and dementia due to Alzheimer's disease. The questionnaire was scored using the weighted average (WA) and item response theory (IRT) scoring method. Diagnostic accuracy was examined using receiver–operating characteristic (ROC) curves. The area under the curves (AUC) was calculated with 95% confidence intervals (CI). The correlation between IRT and WA scores was strong and significant (r=-0.980, p<0.001). The AUC for the IRT scores of A-IADL-Q was 0.832 (95% CI: 0.729 to 0.909), while the AUC for the WA scores of A-IADL-Q was 0.848 (95% CI: 0.746 to 0.920). Both were significantly different from the AUC of 0.5 (p<0.001). There was no significant difference between the AUCs of IRT and WA scoring (z=1.157; p=0.247). Cutoffs and the highest combination of sensitivity and specificity for the IRT (sensitivity 0.767; specificity 0. 844) and WA (sensitivity 0.744; specificity 0. 844) scores of A-IADL-Q were calculated. We have shown that A-IADL-Q has moderate diagnostic accuracy in differentiating dementia and MCI. This instrument can be used in combination with cognitive measures to diagnose dementia in its early stages.

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“…The A/T/N classification system further refines the diagnostic process [ 5 ]. The clinical presentation of AD is categorized into three phases: the asymptomatic phase; followed by the stage of mild cognitive impairment (MCI); and lastly, dementia, characterized by a decline in activities of daily living (ADL) due to cognitive impairment [ 6 , 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Matrix Remodeling Enzymes as Potential Fluid Biomarkers of Neurodegeneration in Alzheimer’s Disease

Bašić,

Milošević,

Djordjević

et al. 2024

IJMS

Self Cite

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This study investigated the diagnostic accuracy of plasma biomarkers—specifically, matrix metalloproteinase (MMP-9), tissue inhibitor of metalloproteinase (TIMP-1), CD147, and the MMP-/TIMP-1 ratio in patients with Alzheimer’s disease (AD) dementia. The research cohort comprised patients diagnosed with probable AD dementia and a control group of cognitively unimpaired (CU) individuals. Neuroradiological assessments included brain magnetic resonance imaging (MRI) following dementia protocols, with subsequent volumetric analysis. Additionally, cerebrospinal fluid (CSF) AD biomarkers were classified using the A/T/N system, and apolipoprotein E (APOE) ε4 carrier status was determined. Findings revealed elevated plasma levels of MMP-9 and TIMP-1 in AD dementia patients compared to CU individuals. Receiver operating characteristic (ROC) curve analysis demonstrated significant differences in the areas under the curve (AUC) for MMP-9 (p < 0.001) and TIMP-1 (p < 0.001). Notably, plasma TIMP-1 levels were significantly lower in APOE ε4+ patients than in APOE ε4− patients (p = 0.041). Furthermore, APOE ε4+ patients exhibited reduced hippocampal volume, particularly in total, right, and left hippocampal measurements. TIMP-1 levels exhibited a positive correlation, while the MMP-9/TIMP-1 ratio showed a negative correlation with hippocampal volume parameters. This study sheds light on the potential use of TIMP-1 as a diagnostic marker and its association with hippocampal changes in AD.

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Importance of a functional measure in the evaluation of patients in a memory clinic: Validation of the Serbian version of the Amsterdam instrumental activities of daily living questionnaire

Cited by 5 publications

References 31 publications

The INFLUENCE OF THE APOEε4 ALLELE ON PRO-INFLAMMATORY CYTOKINE LEVELS IN THE CEREBROSPINAL FLUID OF PATIENTS WITH ALZHEIMER’S DISEASE

The INFLUENCE OF THE APOEε4 ALLELE ON PRO-INFLAMMATORY CYTOKINE LEVELS IN THE CEREBROSPINAL FLUID OF PATIENTS WITH ALZHEIMER’S DISEASE

Assessment of the Instrumental Activities of Daily Living in Mild Cognitive Impairment and Dementia Due to Alzheimer's Disease: Diagnostic Accuracy of the Serbian Version of the Amsterdam Iadl Questionnaire

Matrix Remodeling Enzymes as Potential Fluid Biomarkers of Neurodegeneration in Alzheimer’s Disease

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