Abstract. Simulations of the glacial-interglacial history of the Antarctic Ice Sheet provide insights into dynamic threshold behavior and estimates of the ice sheet’s contributions to global sea-level changes, for both the past, present and future. However, boundary conditions are weakly constrained, in particular, at the interface of the ice-sheet and the bedrock. Also climatic forcing covering the last glacial cycles is uncertain as it is based on sparse proxy data. We use the Parallel Ice Sheet Model (PISM) to investigate the dynamic effects of different choices of input data, e.g. for modern basal heat flux or reconstructions of past changes of sea-level and surface temperature. As computational resources are limited, glacial-cycle simulations are performed using a comparably coarse model grid of 16 km and various parameterizations, e.g. for basal sliding, iceberg calving or for past variations of precipitation and ocean temperatures. In this study we evaluate the model's transient sensitivity to corresponding parameter choices and to different boundary conditions over the last two glacial cycles. It hence serves as a cookbook for the growing community of PISM users. We identify relevant model parameters and motivate plausible parameter ranges for a Large Ensemble analysis, which is described in a companion paper.