Importance of Candida infection and fluconazole resistance in women with vaginal discharge syndrome in Namibia

Dunaiski, Cara M.; Kock, Marleen M.; Jung, Hyunsul; Peters, Remco P. H.

doi:10.1186/s13756-022-01143-6

Cited by 7 publications

(3 citation statements)

References 57 publications

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“…VVC is considered the second most common vaginal infection after BV, and it is mainly caused by the opportunist fungus Candida ( Willems et al., 2020 ). According to published research, fluconazole is widely used in the treatment of VVC; however, its function is to inhibit the growth of Candida but not eradicate it ( Dunaiski et al., 2022 ). This can lead to the emergence of fluconazole resistance.…”

Section: Probiotic Lactobacilli In the Treatment Of Vaginal Infectionsmentioning

confidence: 99%

Use of probiotic lactobacilli in the treatment of vaginal infections: In vitro and in vivo investigations

Liu

et al. 2023

Front. Cell. Infect. Microbiol.

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The vaginal microbiome is a distinct component of the human microbiome that is colonized by a wide variety of microorganisms. Lactobacilli are the most frequently identified microorganisms in the healthy human vagina. These Gram-positive bacilli can acidify the vaginal microenvironment, inhibit the proliferation of other pathogenic microorganisms, and promote the maintenance of a eubiotic vaginal microbiome. However, a vaginal flora with a reduced proportion or abundance of lactobacilli is associated with various vaginal infections that have been linked to serious health consequences such as infertility, preterm birth, pelvic inflammatory disease, premature rupture of membranes, and miscarriage. Due to their “Generally Recognized as Safe” classification and critical role in vaginal health, probiotic lactobacilli have been widely used as an alternative or adjunct to traditional antibiotic therapy for the treatment of vaginal infections and restoration of the vaginal microbiome. This review focuses on the significant role of probiotic lactobacilli in the vaginal microenvironment and discusses the use of probiotic lactobacilli in the treatment of female vaginal infections in vitro and in vivo.

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Section: Probiotic Lactobacilli In the Treatment Of Vaginal Infectionsmentioning

confidence: 99%

Use of probiotic lactobacilli in the treatment of vaginal infections: In vitro and in vivo investigations

Liu

et al. 2023

Front. Cell. Infect. Microbiol.

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“…These rates of antifungal resistance are in line with reports from other parts of the world, such as Cameroon and Uganda, as well as a previous report that included a different cohort from Namibia. [20][21][22] The observed occurrence of fluconazole-resistant strains generates a serious concern about Candida treatment in our syndromic management setting, given the lack of access to antifungal susceptibility testing and limited access to alternative, non-azole, and therapeutic options.…”

Section: Discussionmentioning

confidence: 99%

Prospective Cohort Study of Treatment Outcomes of Vaginal Discharge Syndrome in Women in Windhoek, Namibia

Dunaiski,

Kock,

Jung

et al. 2024

Sexual Trans Dis

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Background Syndromic treatment is the standard of care for vaginal discharge syndrome (VDS) in resource-constrained settings. However, the outcomes of VDS treatment have not been well documented. This study aimed to determine the incidence, risk factors, and microbial etiology of treatment failure in women with VDS. Methods This prospective cohort study of women with VDS was conducted between September 2021 and March 2022 at Katutura Intermediate Hospital in Windhoek, Namibia. Microbiological analyses of sexually transmitted infections (STI) (Chlamydia trachomatis; Neisseria gonorrhoeae; Trichomonas vaginalis; Mycoplasma genitalium), bacterial vaginosis (BV), and vulvovaginal candidiasis (VVC) were performed. Treatment outcomes were assessed at 7 and 30 days after treatment, followed by microbial investigation in case of treatment failure. Results One hundred and nine women were enrolled and 94 (86%) completed the follow-up. At baseline, 37/109 (40%) women were diagnosed with STI, 47/109 (43%) with BV and 45/109 (41%) with VVC. Candida albicans (33/45; 73%) was the main pathogen in VVC, with fluconazole resistance detected in 8/33 (24%) isolates; 10/12 (80%) of non-albicans Candida species showed resistance. The incidence of treatment failure was 3.6 per 100 person-years at 7 days and 1.0 per 100 person-years at 30 days follow-up; 17/94 (18%) women had recurrent VDS and 12/94 (13%) women had persistent VDS. VVC (OR 4.3; 95% CI 1.7-11, p = 0.002) at baseline was associated with treatment failure. Conclusions Treatment failure after syndromic management of VDS is common in resource-constrained settings. Access to diagnostic testing, including fungal culture and susceptibility testing, is recommended to improve outcomes.

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“…Asumsi peneliti, dari penelitian yang telah dilakukan maka dapat disimpulkan bahwa pentingnya peran petugas kesehatan dalam pencegahan keputihan yang meliputi peran edukator, konselor, motivator, maupun fasilitator, maka perlu upaya peningkatan komitmen dari petugas kesehatan dalam meningkatkan kinerja pelayanan kesehatan reproduksi khususnya keputihan menjadi lebih baik lagi dengan mengerahkan segala kemampuan, tenaga, dan waktu untuk mewujudkan peranperannya dalam pemberian pelayanan kesehatan remaja (Dunaiski, 2022). Selain itu, perlu mempertahankan dan meningkatkan lagi peran yang sudah baik serta perlu mengoptimalkan peran-peran yang belum baik dalam pemberian pelayanan pada remaja (Hashemi, 2021).…”

Section: Hubungan Peran Petugas Kesehatan Dengan Kejadian Keputihan P...unclassified

Hubungan Personal Hygiene, Kecemsan, Peran Petugas Kesehatan Terhadap Kejadian Keputihan pada Wanita Usia Subur (WUS) di Kampung Panahegan RT.02 RW.02 Desa Gasol Cianjur Tahun 2023

Dewi,

Fatimah,

Rini

2023

phms

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Vaginal discharge is a common female reproductive health problem. Vaginal discharge can be caused by various factors, one of which is poor personal hygiene. The aim of this research is to determine the relationship between personal hygiene, anxiety and the role of health workers on the incidence of vaginal discharge in women of childbearing age. This research method uses a quantitative research design with a cross sectional approach with a population of 40 women of childbearing age in KP. Panahegan, Gasol Village, Cianjur. The researcher took a sample of 40 people. The results of research using the Chi-square test show that there is a significant relationship between personal hygiene and the incidence of vaginal discharge (P value = 0.019). The better the personal hygiene, the lower the incidence of vaginal discharge. There is a relationship between anxiety and the incidence of vaginal discharge (P value = 0.009). There is a significant relationship between the role of health workers and the incidence of vaginal discharge (P value = 0.026). The better the respondent's perception of the role of health workers, the lower the incidence of vaginal discharge.

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Importance of Candida infection and fluconazole resistance in women with vaginal discharge syndrome in Namibia

Cited by 7 publications

References 57 publications

Use of probiotic lactobacilli in the treatment of vaginal infections: In vitro and in vivo investigations

Use of probiotic lactobacilli in the treatment of vaginal infections: In vitro and in vivo investigations

Prospective Cohort Study of Treatment Outcomes of Vaginal Discharge Syndrome in Women in Windhoek, Namibia

Hubungan Personal Hygiene, Kecemsan, Peran Petugas Kesehatan Terhadap Kejadian Keputihan pada Wanita Usia Subur (WUS) di Kampung Panahegan RT.02 RW.02 Desa Gasol Cianjur Tahun 2023

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