Importance of Circadian Rhythm in Drug Administration Timing

Abstract

Chronobiology plays a significant role in comprehending and managing both psychiatric disorders, such as mood and eating disorders [1,2], and physical illnesses, such as hypertension and Parkinson's disease [3][4][5]. By recognizing the disruptions in circadian rhythms associated with these conditions, chronobiological interventions, such as timed medication administration, light therapy, and lifestyle modifications, can be applied to improve treatment outcomes. The impact of circadian rhythms on various bodily functions presents a challenge in determining the most suitable timing and dosage for drug administration, solely relying on the drug's half-life without accounting for these rhythms. Regrettably, circadian rhythms are frequently overlooked when determining the appropriate timing for drug administration, highlighting the need for increased attention to the influence of circadian rhythms in pharmacotherapy.Chronopharmacology is an interdisciplinary field that unites pharmacology and chronobiology, the study of biological rhythms, to investigate the correlation between biological rhythms and the effectiveness and potential toxicity of drugs. This field acknowledges the impact of biological processes, including circadian rhythms, on drug metabolism, elimination, and treatment efficacy for specific medical conditions.In clinical situations, the principles of chronopharmacology are critical for optimizing drug therapy for patients. The timing of drug administration can greatly impact the effectiveness and safety of drugs. For instance, some drugs may be more effective when administered at certain times of day, while others may have in-