Importance of defect nanocrystalline calcium hydroxyapatite characteristics for developing the dental biomimetic composites

Goloshchapov, D. L.; Lenshin, A. S.; Савченко, Д. В.; Seredin, P. V.

doi:10.1016/j.rinp.2019.102158

Cited by 25 publications

(24 citation statements)

References 35 publications

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“…The mineral basis of the bioinspired materials in our work was selected nanocrystalline cHAps, whose physicochemical properties are closest to the natural apatite of the dental matrix [31]. Samples of nano-cHAp were obtained using the wet chemistry method of titrating a concentrated solution of calcium hydroxide (Ca(OH) 2 ) with 0.3 M orthophosphoric acid (H 3 PO 4 ) solution.…”

Section: Methodsmentioning

confidence: 99%

Raman and XANES Spectroscopic Study of the Influence of Coordination Atomic and Molecular Environments in Biomimetic Composite Materials Integrated with Dental Tissue

et al. 2021

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In this work, for the first time, the influence of the coordination environment as well as Ca and P atomic states on biomimetic composites integrated with dental tissue was investigated. Bioinspired dental composites were synthesised based on nanocrystalline calcium carbonate-substituted hydroxyapatite Ca4ICa6IIPO46−xCO3x+yOH2−y (nano-cHAp) obtained from a biogenic source and a set of polar amino acids that modelled the organic matrix. Biomimetic composites, as well as natural dental tissue samples, were investigated using Raman spectromicroscopy and synchrotron X-ray absorption near edge structure (XANES) spectroscopy. Molecular structure and energy structure studies revealed several important features related to the different calcium atomic environments. It was shown that biomimetic composites created in order to reproduce the physicochemical properties of dental tissue provide good imitation of molecular and electron energetic properties, including the carbonate anion CO32− and the atomic Ca/P ratio in nanocrystals. The features of the molecular structure of biomimetic composites are inherited from the nano-cHAp (to a greater extent) and the amino acid cocktail used for their creation, and are caused by the ratio between the mineral and organic components, which is similar to the composition of natural enamel and dentine. In this case, violation of the nano-cHAp stoichiometry, which is the mineral basis of the natural and bioinspired composites, as well as the inclusion of different molecular groups in the nano-cHAp lattice, do not affect the coordination environment of phosphorus atoms. The differences observed in the molecular and electron energetic structures of the natural enamel and dentine and the imitation of their properties by biomimetic materials are caused by rearrangement in the local environment of the calcium atoms in the HAp crystal lattice. The surface of the nano-cHAp crystals in the natural enamel and dentine involved in the formation of bonds with the organic matrix is characterised by the coordination environment of the calcium atom, corresponding to its location in the CaI position—that is, bound through common oxygen atoms with PO4 tetrahedrons. At the same time, on the surface of nano-cHAp crystals in bioinspired dental materials, the calcium atom is characteristically located in the CaII position, bound to the hydroxyl OH group. The features detected in the atomic and molecular coordination environment in nano-cHAp play a fundamental role in recreating a biomimetic dental composite of the natural organomineral interaction in mineralised tissue and will help to find an optimal way to integrate the dental biocomposite with natural tissue.

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Section: Methodsmentioning

confidence: 99%

Raman and XANES Spectroscopic Study of the Influence of Coordination Atomic and Molecular Environments in Biomimetic Composite Materials Integrated with Dental Tissue

et al. 2021

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“…Therefore, synthetic HAp possesses similar chemical formula and properties as the main inorganic component (i.e., biological apatite) of both hard tissues (bone and teeth) and has extensively been applied in orthopedic and dental applications for hard tissue repair or regeneration. The use of HAp as a bone substitute includes partial or complete augmentation of bone, filling teeth and bones, or as coating materials on orthopedic and dental implants (Goloshchapov et al, 2019). In the last decades, artificial bone grafts with only HAp or surface coatings with HAp or HAp/polymer-based biomaterials have broadly been developed and investigated.…”

Section: Hydroxyapatitementioning

confidence: 99%

Additive Manufacturing Methods for Producing Hydroxyapatite and Hydroxyapatite-Based Composite Scaffolds: A Review

et al. 2019

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Hydroxyapatite (HAp) has been considered for decades an ideal biomaterial for bone repair due to its compositional and crystallographic similarity to bioapatites in hard tissues. However, fabrication of porous HAp acting as a template (scaffold) for supporting bone regeneration and growth has been a challenge to biomaterials scientists. The introduction of additive manufacturing technologies, which provide the advantages of a relatively fast, precise, controllable, and potentially scalable fabrication process, has opened new horizons in the field of bioceramic scaffolds. This review focuses on three-dimensional-printed HAp scaffolds and related composite systems, where the calcium phosphate phase is combined with other ceramics or polymers improving the mechanical properties and/or imparting special extra-functionalities. The main applications of three-dimensional-printed HAp scaffolds in bone tissue engineering are presented and discussed; furthermore, this review also emphasizes the most recent achievements toward the development and testing of multifunctional HAp-based systems combining multiple properties for advanced therapy (e.g., bone regeneration, antibacterial effect, angiogenesis, and cancer treatment).

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“…It is important to emphasize that the absorption band at the range of 1524–1365 cm – 1 could relate to the characteristic vibrations from CHA of B-type [ 38 ]. However, as the results of our work [ 43 ] showed, vibrational modes of the organic enamel matrix component have a different characteristic profile and significantly higher intensity.…”

Section: Resultsmentioning

confidence: 99%

“…In all specimens, a cavity was formed in the enamel preserving the untreated dentin, using a water-cooling system to avoid overheating of the dental matrix. The surface of the obtained cavity was covered with a biocomposite buffer system containing nanocrystalline carbonate-substituted calcium hydroxyapatite (CHA) developed by us and corresponding in the main characteristics to human dentin-enamel apatite [ 37 , 38 ] and a number of amino acids present in the organic matrix of dentin/enamel: L-histidine, L-lysine hydrochloride, L-arginine hydrochloride, and hyaluronic acid. The ratio of the components was chosen according to their content in the enamel matrix [ 39 ].…”

Section: Methodsmentioning

confidence: 99%

Organic-Mineral Interaction between Biomimetic Materials and Hard Dental Tissues

et al. 2020

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The aim of the investigation was to study the integration between native human dental tissue and new-generation biomimetic materials replicating the mineral-organic complex of dentin and enamel using IR microspectroscopy for multidimensional visualization and analysis. Materials and Methods. The conditions for stable integration at the interface between biomimetic material and natural hard tissue were identified using a biocomposite buffer system of nanocrystalline carbonate-substituted calcium hydroxyapatite corresponding in its total characteristics to human dentin-enamel apatite and a number of amino acids present in the organic matrix of dentin and enamel: L-histidine, L-lysine hydrochloride, L-arginine hydrochloride, and hyaluronic acid. The finished samples were studied using IR microspectroscopy on IRM channel equipment (The Australian Synchrotron, Melbourne, Australia). Results. The characteristic features of the biomimetic buffer layer at the interface between the enamel and dental material were revealed and visualized based on IR mapping of absorption intensity for particular functional molecular groups with the use of synchrotron radiation, location of the functional groups involved in the processes of biomimetic composite integration was identified.

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Importance of defect nanocrystalline calcium hydroxyapatite characteristics for developing the dental biomimetic composites

Cited by 25 publications

References 35 publications

Raman and XANES Spectroscopic Study of the Influence of Coordination Atomic and Molecular Environments in Biomimetic Composite Materials Integrated with Dental Tissue

Raman and XANES Spectroscopic Study of the Influence of Coordination Atomic and Molecular Environments in Biomimetic Composite Materials Integrated with Dental Tissue

Additive Manufacturing Methods for Producing Hydroxyapatite and Hydroxyapatite-Based Composite Scaffolds: A Review

Organic-Mineral Interaction between Biomimetic Materials and Hard Dental Tissues

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