Importance of early diagnosis and follow-up in multiple endocrine neoplasia (MEN II B)

Frank, K.; Raue, Friedhelm; Gottswinter, J.; Heinrich, U.; Meybier, H.; Ziegler, Reinhard

doi:10.1007/bf00445797

Cited by 10 publications

(2 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, no objective responses were observed. 92,93 Vandetanib (ZD 6474, Zactima; AstraZeneca, Wilmington, DE) is an oral TKI that targets the VEGF-2 and 3 receptors, RET (including the M918T RET mutation), and at higher concentrations, the epithelial growth factor (EGF) receptor. A recently completed open-label phase II trial investigated vandetanib activity in 30 MTC patients using a dose of 300 mg daily.…”

Section: Systemic Therapymentioning

confidence: 99%

Thyroid Cancer in Young Adults

Ying

Huh

Bottomley

et al. 2009

Seminars in Oncology

View full text Add to dashboard Cite

Section: Systemic Therapymentioning

confidence: 99%

Thyroid Cancer in Young Adults

Ying

Huh

Bottomley

et al. 2009

Seminars in Oncology

View full text Add to dashboard Cite

“…trachealen Lymphgewebes beidseits (42,44) erforderlich. Ob allerdings eine radikale Neck-Dissektion bei bereits vorhandenen Lymphknotenmetastasen die Prognose gegenüber einem modifizierten Vorgehen verbessert, ist nicht sicher (5,8,11,13,17,29,42,44).…”

Section: Regionare Lymphknotenunclassified

Chirurgische Strategien bei Schilddrüsenerkrankungen im Kindes- und Jugendalter

Pistor

Waag²,

Kap-herr³

1990

Eur J Pediatr Surg

View full text Add to dashboard Cite

In the Department of Paediatric Surgery of the University Hospital of Mainz and the Department of Paediatric Surgery of the University Hospital of Frankfurt/M 90 children with thyroid gland lesions were operated on between 1970 and 1988. 78 patients had benign findings and 12 had malignant tumours. The most frequent operative indication for benign lesions was the euthyroid goitre (57 patients). We found nodular goitre in 45 patients, cystic goitre in 11 patients, and diffuse goitre in only 1 patient. 20 children were suffering from hyperthyroidism (11 with Basedow's disease, 9 with autonomy) and 1 from Hashimoto's thyroiditis. Among the malignant tumours, papillary carcinomas were the most frequent (5 patients), followed by follicular carcinomas (2 patients) and C-cell carcinomas (2 patients), and 1 case each of C-cell hyperplasia, retothelial sarcoma and malignant lymphoma. The following operative interventions were necessary: Among the patients with the benign findings, 28 unilateral subtotal resections were done (17 right side and 11 left side). 24 lesions were enucleated, 24 goitres were subjected to subtotal bilateral resection; in 1 case subtotal resection on the right side and hemithyroidectomy on the left side was performed, and in one patient polresection was necessary. All the 12 patients with malignant tumours underwent thyroidectomy: In 4 cases one-step operations were done and in other 8 cases multistep operations were performed.(ABSTRACT TRUNCATED AT 250 WORDS)

show abstract