Importance of HLA typing, PRA and DSA tests for successful parathyroid allotransplantation

Living-donor fresh parathyroid tissue allotransplantation as treatment for permanent hypoparathyroidism: case report

“…ABO and Human Leucocyte Antigens (HLA) compatibility are among them. 11,13,15,16,19 Risks related to immunosuppression, such as susceptibility to infections and cancer, can be mitigated through techniques that hinder the immune recognition of the graft. They consist of encapsulated, cultured, and cryopreserved parathyroid tissue.…”

“…On the other hand, advances in the management of immunosuppression in solid organ transplants (for example, in kidney and liver transplants) have enabled good safety with fewer adverse effects. 24 Some studies on parathyroid allotransplantation report the safety of immunosuppression, whether used in the short [11][12][13]18,21 or long term. [15][16][17]19,20 The protocol used in our case followed steps already described in other studies, both about the choice of the donor and the surgical technique and graft implantation site.…”

“…At the same time, it corrects the PTH production deficiency and as a real possibility of cure through the drastic reduction or even suspension of calcium and calcitriol replacement. [9][10][11][12][13][14][15][16][17][18][19][20][21][22] In addition, it is a procedure with considerably lower costs than rhPTH, 19 which can be interesting in countries with difficulty in financing more expensive therapies.…”

Periferik kan mononükleer hücrelerin primer paratiroit dokusu hücreleri ile ko-kültürünün verimliliği

“…Paratiroit nakli ile ilgili en geniş immünolojik tarama testi kriterleri 2019 yılında Yücesan ve ark. tarafından gerçekleştirilmiş olup; negatif PRA, negatif lenfosit-CXM ve negatif mikrolenfositotoksisite testi ile gerçekleştirilen nakildir (11). Paratiroit nakli ile ilgili literatürdeki immünolojik kriterler halen standardize edilmemiştir.…”

Parati̇roi̇t Nakli̇ Bekleyen Hi̇poparati̇roi̇di̇ Hastalarinin Naki̇l Bekleme Süreleri̇ni̇n Değerlendi̇ri̇lmesi̇

“…Ek olarak, paratiroit naklinde immün baskılayıcı ilaçların kullanımı kısıtlı ve kısa sürelidir (5,21). Böbrek ve akciğer nakillerinde alıcının ret riskini öngörmede kullanılan testlerden biri olan PRA seviyesi, paratiroit naklinde de ayrıca değerlendirilmektedir (22)(23)(24). Bu nedenle paratiroit nakli bekleyen listesindeki PRA seviyesi yüksek olan hastalar birimimizde ayrı bir grup olarak takip edilmektedir.…”