Importance of house dust and storage mites in canine atopic dermatitis in the geographic region of Galicia, Spain

Goicoa, A.; Espino, L.; Rodriguez, Isabel V.; Puigdemont, Anna; Brazı́s, Pilar; Rejas, Juan

doi:10.1556/avet.56.2008.2.3

Cited by 12 publications

(5 citation statements)

References 15 publications

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“…Also, literature data confirms a strong reaction to this allergen (47 -80%) when applied in the concentration of 250 PNU/mL, which we used (Carloti et al, 1994;Zur et al, 2002;Tarpataki et al, 2006;Espino et al, 2008;Chanthick et al, 2008;Sung et al, 2009). To our knowledge, there is only one report stating that house mite allergen is not a common cause of atopic dermatitis in dogs (Koch et al, 1994).…”

Section: Clinical Examinationsupporting

confidence: 62%

The role of Ambrosia artemisiifolia allergen in canine atopic dermatitis

Polović¹,

Popović²,

Lazarevic³

et al. 2010

Acta vet. (Beogr.)

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Pollens from Ambrosia species have a strong allergenic potential and they represent a complex mixture of at least 52 different antigens. This weed is widespread in Serbia and has a long pollination period (appr. 100 days). Pollens are present in very high concentrations during the pollination season (up to 300 pg/m3 of air). Fifty dogs with a clinical diagnosis of canine atopic dermatitis (CAD) and positive intradermal skin test (IDST) reactions to other environmental allergens were included in this study along with 30 dogs without clinical signs of CAD. Both groups were tested intradermally with Ambrosia artemisiifolia extract in concentration of 1000 PNU/mL (provided by ''Institute of virology, vaccines and sera - Torlak''). We have found that Ambrosia extract was second most common allergen to yield positive intradermal test reactions just after house dust mites. The positive reaction of IDST was observed in 66% of the atopic dogs and in 10% of clinically healthy dogs. Dogs that had a positive reaction on intradermal skin test to Ambrosia pollens, mostly showed secondary skin lesions on the pads and perioral skin. In 88% of cases, Malassezia pachydermatis have been isolated from the skin in an increased number and 64% of dogs had otitis externa. These results indicate, that allergens from Ambrosia artemisifolia are of great importance in the etiopathogenesis of atopic dermatitis in dogs originating from the Belgrade region

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Section: Clinical Examinationsupporting

confidence: 62%

The role of Ambrosia artemisiifolia allergen in canine atopic dermatitis

Polović¹,

Popović²,

Lazarevic³

et al. 2010

Acta vet. (Beogr.)

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“…Tyrophagus putrescentiae (36%-80%) and Acarus siro (18%-80%)] is common too. 48,53,56,[59][60][61][62] Dogs with AD are frequently (≥45%) co-sensitised to house dust and storage mites, which could be the result of parallel exposure and sensitisation to different mite species and/or of in vitro crossreactivity. 63 A high rate of cross-reactivity among dust mites, storage mites or ectoparasites such as sarcoptic mites may explain false-positive results in allergen testing.…”

Section: House Dust and Storage Mite Allergensmentioning

confidence: 99%

“…Dermatophagoides farinae appears to be the most prevalent HDM allergen involved in cAD worldwide, yet sensitisation to storage mites [e.g. Tyrophagus putrescentiae (36%–80%) and Acarus siro (18%–80%)] is common too 48,53,56,59–62 . Dogs with AD are frequently (≥45%) co‐sensitised to house dust and storage mites, which could be the result of parallel exposure and sensitisation to different mite species and/or of in vitro cross‐reactivity 63 .…”

Section: Allergensmentioning

confidence: 99%

Update on the role of genetic factors, environmental factors and allergens in canine atopic dermatitis

Hensel,

Saridomichelakis,

Eisenschenk

et al. 2023

Veterinary Dermatology

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BackgroundCanine atopic dermatitis (cAD) is a common, complex and multifactorial disease involving, among others, genetic predisposition, environmental factors and allergic sensitisation.ObjectiveThis review summarises the current evidence on the role of genetic and environmental factors and allergic sensitisation in the pathogenesis of cAD since the last review by ICADA in 2015.Materials and MethodsOnline citation databases and proceedings from international meetings on genetic factors, environmental factors and allergens relevant to cAD that had been published between 2015 and 2022 were reviewed.ResultsDespite intensive research efforts, the detailed genetic background predisposing to cAD and the effect of a wide range of environmental factors still need more clarification. Genome‐wide association studies and investigations on genetic biomarkers, such as microRNAs, have provided some new information. Environmental factors appear to play a major role. Lifestyle, especially during puppyhood, appears to have an important impact on the developing immune system. Factors such as growing up in a rural environment, large size of family, contact with other animals, and a nonprocessed meat‐based diet may reduce the risk for subsequent development of cAD. It appears that Toxocara canis infection may have a protective effect against Dermatophagoides farinae‐induced cAD. House dust mites (D. farinae and D. pteronyssinus) remain the most common allergen group to which atopic dogs react. Currently, the major allergens related to D. farinae in dogs include Der f 2, Der f 15, Der f 18 and Zen 1.Conclusions and Clinical RelevanceCanine atopic dermatitis remains a complex, genetically heterogeneous disease that is influenced by multiple environmental factors. Further, well‐designed studies are necessary to shed more light on the role of genetics, environmental factors and major allergens in the pathogenesis of cAD.

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“…Unlike humans, atopic dogs appear to react to high molecular weight (HMW) D. farinae allergens (Olivry et al 2017; Moya et al 2021). Previous studies reported that storage mite sensitivity in dogs seemed to be more important than dust mite sensitivity (Arlian et al 2003;Goicoa et al 2008). However, the role of T. putrescentiae in respiratory allergic disease is still controversial in Korea.…”

Section: Introductionmentioning

confidence: 99%

Comparison of sensitization pattern to dust mite allergens between atopic dermatitis patients and dogs and non-specific reactivity of canine IgE to storage mite, Tyrophagus putrescentiae

Song

Lee

Jeong

et al. 2022

Preprint

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House dust mite is common cause of atopic dermatitis (AD) both in human and dogs. Detection of serum IgE to allergen is commonly used to diagnose allergic diseases. However, false-positive reactions due to cross-reactivity and non-specific reactivity may lead to misdiagnosis. We compared human and canine IgE reactivities to mite component allergens. Canine IgE-reactive components of D. farinae and T. putrescentiae were identified by tandem mass spectrometry. Recombinant proteins were produced and IgE reactivities to component allergens were assessed by ELISA and inhibition assays using sera from AD patients and dogs. Canine IgE-reactive proteins (Der f 1, Der f 11, Tyr p 4, Tyr p 8, Tyr p 11, Tyr p 28) were identified by proteome analysis. The majority of patients were sensitized to Der f 1 (93.3%) and Der f 2 (86.7%). Dogs showed high sensitization to Der f 2 (94.1%) and Der f 18 (84.6%). Both patients and dogs showed low IgE binding frequency to Tyr p 8, 43.3% and 4% respectively. The ELISA inhibition study indicated that canine IgE reactivity to T. putrescentiae is mostly due to non-specific reaction and cross-reaction with D. farinae. Different IgE sensitization patterns were shown between allergic human and dogs with AD, especially to Der f 18 in Korea for the first time. Furthermore, non-specific canine IgE reactivity to storage mite indicates the possible misdiagnoses. Standardizations focused on the major canine allergen content of extracts should be developed. This will allow precision diagnosis and individuated treatments for each patient and atopic dog.

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Importance of house dust and storage mites in canine atopic dermatitis in the geographic region of Galicia, Spain

Cited by 12 publications

References 15 publications

The role of Ambrosia artemisiifolia allergen in canine atopic dermatitis

The role of Ambrosia artemisiifolia allergen in canine atopic dermatitis

Update on the role of genetic factors, environmental factors and allergens in canine atopic dermatitis

Comparison of sensitization pattern to dust mite allergens between atopic dermatitis patients and dogs and non-specific reactivity of canine IgE to storage mite, Tyrophagus putrescentiae

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