Importance of IL-10 Modulation by Probiotic Microorganisms in Gastrointestinal Inflammatory Diseases

LeBlanc, Alejandra de Moreno de; Carmen, Silvina del; Zurita-Turk, Meritxell; Rocha, Clarissa Santos; Guchte, Maarten van de; Azevedo, Vasco; Miyoshi, Anderson; LeBlanc, Jean Guy

doi:10.5402/2011/892971

Cited by 100 publications

(75 citation statements)

References 93 publications

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“…these patients [37]. IL-10 is an anti-inflammatory cytokine that is involved in the suppression of the release of proinflammatory cytokines such as TNF-, interferon-(IFN-) and IL-1 [38]. Recently, the first pediatric, randomized, placebo-controlled trial using this probiotic mixture in patients with ulcerative colitis was published.…”

Section: Rhamnosus Gg L Rhamnosusmentioning

confidence: 99%

Mechanisms Involved in the Anti-Inflammatory Properties of Native and Genetically Engineered Lactic Acid Bacteria

LeBlanc¹,

Carmen²,

Zurita-Turk³

et al. 2012

AIA

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Lactic acid bacteria (LAB) represent a heterogeneous group of microorganisms that have been shown to possess therapeutic properties since they are able to prevent the development of some diseases, as shown mostly on animal models for cancer, infections and gastrointestinal disorders such as intestinal inflammation. LAB have been shown to regulate mucosal immune responses by modulating the production and liberation of regulatory agents such as cytokines by the host. Some of these cytokines, such as the anti-inflammatory interleukin-10 (IL-10), modulate the inflammatory immune response, thus immunomodulation is a mechanism by which LAB can prevent certain inflammatory bowel diseases (IBD). Since oxidative stress participates in the inflammatory processes and in the appearance of damages in pathologies of the gastrointestinal tract of humans such as IBD, LAB could also prevent inflammation by eliminating reactive oxygen species (ROS) through the activity of antioxidant enzymes. In order to obtain novel strains or enhance beneficial effects of LAB, genetic engineering has been used to produce either antioxidant enzymes (such as catalases and superoxide dismutases) or anti-inflammatory cytokines (such as IL-10) producing LAB. These novel strains have successfully been used to prevent inflammatory bowel diseases in animal models and could be evaluated in human clinical trials. Here, we present an overview of the current knowledge of the mechanisms by which LAB can be used to prevent undesired intestinal inflammatory responses and could be used as a therapeutic tool for IBD.

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Section: Rhamnosus Gg L Rhamnosusmentioning

confidence: 99%

Mechanisms Involved in the Anti-Inflammatory Properties of Native and Genetically Engineered Lactic Acid Bacteria

LeBlanc¹,

Carmen²,

Zurita-Turk³

et al. 2012

AIA

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“…It is well known that IL-10 down-regulates inflammatory cascades through the suppression of pro-inflammatory cytokines. However, oral treatment with IL-10 is difficult because of its low half-life in the gastrointestinal tract (GIT), and systemic treatments have not been proven effective in inducing clinical remission and have been associated with undesirable side effects [de Moreno de LeBlanc et al, 2011]. For these reasons, some groups have proposed the use of IL-10-producing LAB for the local delivery of this cytokine in the GIT and to prevent the risks associated to systemic administration [Li and He, 2004].…”

Section: Introductionmentioning

confidence: 99%

“…These advances have led to the creation of interesting strains, some of which have recently been tested using different inflammation animal models confirming their potential for the prevention and treatment of IBD [Carroll et al, 2007;Han et al, 2006;LeBlanc et al, 2011;Rochat et al, 2007;Watterlot et al, 2010].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Anti-Inflammatory Effect of Milk Fermented by a Strain of IL-10-Producing Lactococcus lactis Using a Murine Model of Crohn’s Disease

et al. 2011

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Interleukin-10 (IL-10) is the most important anti-inflammatory cytokine at intestinal level, and its absence is involved in inflammatory bowel diseases. However, oral treatment with IL-10 is difficult because of its low survival in the gastrointestinal tract and systemic treatments lead to undesirable side effects. The aim of this paper was to evaluate the anti-inflammatory effect of the administration of milks fermented by Lactococcus lactis strains that produce IL-10 under the control of the xylose-inducible expression system using a trinitrobenzenesulfonic acid-induced colitis murine model. Mice that received milks fermented by L. lactis strains producing IL-10 in the cytoplasm (Cyt strain) or secreted to the product (Sec strain) showed lower damage scores in their large intestines, decreased IFN-γ levels in their intestinal fluids and lower microbial translocation to liver, compared to mice receiving milk fermented by the wild-type strain or those not receiving any treatment. The results obtained in this study show that the employment of fermented milks as a new form of administration of IL-10-producing L. lactisis effective in the prevention of inflammatory bowel disease in a murine model.

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“…In vivo study using dextran sulfate sodium-induced colitis mice model revealed that L. lactis strain prevented the colitis, and proved that L. lactis is safe for human. [24,25] Some of the studies suggested that administration of LAB or IL-10 producing LAB mediated fermented food nullify the consequences of colitis in mice. [26,27] The oral supplementation of Lactobacillus HY7801 introverted the colon shortening and myeloperoxidase activity in 2, 4, 6-trinitrobenzenesulfonic acid-induced colitic mice, and decreased the expression of IL-1β, IL-6, and tumor necrosis factor-alpha, [28] which indicated that LAB could suppress the initiation or development of colitis.…”

Section: Discussionmentioning

confidence: 99%

Screening of lactic acid bacteria with immune modulating property, and the production of lactic acid bacteria mediated fermented soymilk

Sirilun¹,

Chaiyasut²,

Kesika³

et al. 2017

Natl J Physiol Pharm Pharmacol

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Background: Lactic acid bacteria (LAB) are reported to have immune activating property. The genetically modified LAB strains producing interleukin (IL) -10 were under consideration for the treatment of inflammatory bowel diseases (IBD). Soybean is rich in necessary nutrients, and the fermented soybean products are known for its health benefits. Aims and Objectives: The current study was aimed to screen LAB with the immune activating property, and production and evaluation of LAB mediated fermented soymilk product. Materials and Methods: Screening of LAB from the fermented foods collected in Chiang Mai. To select a potent LAB strain, the LAB isolates were scrutinized for acid tolerant, bile tolerant, growth rate, antimicrobial ability, adhesion property, and induction of IL-10 production. The physical properties of fermented soymilk (FSM) were evaluated, and in vitro activation of IL-10 by FSM was assessed using Caco-2 cell line. Results: About 742 LAB strains were isolated from 335 fermented food samples. Based on the tested properties, LAB33 was selected as a potent LAB strain, and used for the fermentation of soymilk for 30 days. The LAB33 FSM was superior in quality regarding probiotic nature and microbiological safety. Conclusion: The results of the study suggested that LAB33 is the potent probiotic strain for the production of soymilk-based fermented functional food supplements for the betterment of IBD patients. Further, strain identification is required to register the strain in a public repository, and sustainable utilization for the benefit of mankind.

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Importance of IL-10 Modulation by Probiotic Microorganisms in Gastrointestinal Inflammatory Diseases

Cited by 100 publications

References 93 publications

Mechanisms Involved in the Anti-Inflammatory Properties of Native and Genetically Engineered Lactic Acid Bacteria

Mechanisms Involved in the Anti-Inflammatory Properties of Native and Genetically Engineered Lactic Acid Bacteria

Evaluation of the Anti-Inflammatory Effect of Milk Fermented by a Strain of IL-10-Producing Lactococcus lactis Using a Murine Model of Crohn’s Disease

Screening of lactic acid bacteria with immune modulating property, and the production of lactic acid bacteria mediated fermented soymilk

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