Importance of immunotherapy in the treatment of recurrent cystitis

Ибишев, Х. С.; Krakhotkin, D.V.; Мамедов, Э. А.; Mantsov, A A; Mamedov, V K; Ибишева, А. Х.

doi:10.21886/2308-6424-2021-9-1-87-94

Cited by 2 publications

(1 citation statement)

References 12 publications

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“…Женщинам с рецидивами цистита, связанными с половым актом, рекомендуют посткоитальную антибиотикопрофилактику, при этом в отечественных и зарубежных клинических рекомендациях прямо указывается на целесообразность ее проведения только при неэффективности неантибактериальных методов [5,6]. В этой связи в нашей стране и за рубежом отмечается существенное повышение интереса к неантибактериальной профилактике рецидивирующих ИНМП [13][14][15]. В настоящее время с этой целью уже нашли применение в широкой клинической практике поведенческие методики, иммуно-и фитопрепараты, пре-и пробиотики [15][16][17].…”

Section: Introductionunclassified

Non-antibiotic prevention of postcoital cystitis in women

Kuzmin¹,

Slesarevskaya²,

Аль-Шукри³

2021

Russian Journal of Woman and Child Health

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Background: postcoital cystitis ranks first among recurrent infections of the lower urinary tract in young women. Their prevention is an important medical social issue. Prescription of antimicrobials for these infections increases antibacterial resistance of urinary tract pathogens, thereby requiring the search for alternative preventive strategies for postcoital cystitis. Aim: to assess the effectiveness of diet correction using biologically active food supplement (BAFS) Ecocystin® containing D-mannose and inulin to prevent coitus-related infections of the lower urinary tract (postcoital cystitis) in women. Patients and Methods: 40 sexually active women aged 18–45 (the mean age 31.9±8.8 years) with recurrent coitus-related infections of the lower urinary tract were enrolled. Women were divided into two groups, i.e., the study group (n=22) and the control group (n=18). Study group women received postcoital preventive treatment for the lower urinary tract infections (one sachet of BAFS Ecocystin® containing 1.5 g of mannose and 1.5 g of inulin no later than 2 hours after sexual intercourse and then another 12 hours later). Control group women received no preventive treatment. The primary indicator of the efficacy of postcoital prophylaxis was the rate of recurrent infections of the lower urinary tract. The additional indicator was the severity of clinical presentations assessed by the Acute Cystitis Symptom Score (ACSS) questionnaire. Follow-up was six months. Results: the rate of recurrent infections of the lower urinary tract was significantly lower in the study group compared to the control group. Recurrences were reported in 27.3% in the study group and 77.8% in the control group over months 1–3 (χ2=10.01, p=0.002) and 13.6% and 72.2%, respectively, over months 4–6 (χ2=14.16, p<0.001). The chances for cystitis exacerbation during the first and the second trimester of the follow-up were 2.9- and 5.3-times lower in the study group compared to the control group. During the first trimester of the follow-up, the recurrence rate was 0.45±0.86 per one woman of the study group and 1.55±1.10 per one of the control group (t=3.6, p<0.001). During the second trimester of the follow-up, the recurrence rate was 0.18±0.50 and 1.50±1.20 (t=4.7, p<0.001), respectively. Women who received BAFS Ecocystin® but developed postcoital cystitis reported much lower symptom severity than the control group. As a result, the study group’s quality of life was significantly higher than the control group’s. Conclusions: BAFS Ecocystin® is a highly effective and well-tolerated preventive tool for postcoital cystitis in women and a pathogenetically reasonable alternative for antibiotics. KEYWORDS: postcoital cystitis, infections of the lower urinary tract, recurrent cystitis, Ecocystin, D-mannose, inulin, non-antibiotic prophylaxis. FOR CITATION: Kuz’min I.V., Slesarevskaya M.N., Al’-Shukri S.Kh. Non-antibiotic prevention of postcoital cystitis in women. Russian Journal of Woman and Child Health. 2021;4(3):209–217 (in Russ.). DOI: 10.32364/2618-8430-2021-4-3-209-217.

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Section: Introductionunclassified

Non-antibiotic prevention of postcoital cystitis in women

Kuzmin¹,

Slesarevskaya²,

Аль-Шукри³

2021

Russian Journal of Woman and Child Health

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The Effectiveness of Alloferon in the Complex Therapy of Chronic Recurrent Papillomavirus Cystitis

Ibishev,

Krahotkin,

Mammadov Vahid

et al. 2023

Themed Collection of Papers From Foreign Intemational Scientific Conference «Joint Innovation - Joint Development». Medical Sci

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Introduction: Chronic recurrent cystitis (CRC) for women is one of the most pressing and unresolved problems of modern urology. Purpose of the research: To study the effectiveness of Alloferon (Allokin-alpha) in the complex therapy of chronic reactive papillomavirus cystitis. Materials and methods: 46 patients with CRC PV-etiology were examined, which, depending on the therapy, were randomized into two groups. Patients of group I (n=22) received combination therapy supplemented with Alloferon, which was injected subcutaneously every 1 day, for a course of 6 injections. Group II (control) (n=24) - combination therapy without study drug. The effectiveness of treatment was assessed immediately after treatment, after 1, 3, 6 months, from the beginning of therapy. Results: When analyzing the results of treatment, a significant improvement in clinical indicators was noted in patients of group I who received complex therapy, which included Alloferon, after 1 month from the start of treatment, there was a significant decrease in pain symptoms and LUTS, an improvement in the quality of life of patients compared with group II. When evaluating the dynamics of laboratory data, in the general analysis of urine, a significant decrease in the level of leukocytes and erythrocytes in the general analysis of urine was noted. In addition, the analysis of the data of cytological examination of urine revealed a decrease in the specific sign of papillomavirus lesions of the bladder - coylocytosis: after 6 months. From the start of therapy, no coylocytes were detected in group I, while in group II, coylocytes in urine were detected in 8 (33.3%) patients. Conclusions: The use of Alloferon (Allokin-alpha) in the complex therapy of patients with CRC PV etiology improved clinical and laboratory parameters after 1 month. after starting therapy, while the undoubted advantage of the drug is a faster reduction in pain, which significantly increased the quality of life.

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Importance of immunotherapy in the treatment of recurrent cystitis

Cited by 2 publications

References 12 publications

Non-antibiotic prevention of postcoital cystitis in women

Non-antibiotic prevention of postcoital cystitis in women

The Effectiveness of Alloferon in the Complex Therapy of Chronic Recurrent Papillomavirus Cystitis

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