Importance of insulin content in infant diet: suggestion for a new infant formula

Shehadeh, Naim; Gelertner, L; Blazer, Shraga; Perlman, Rina; Solovachik, L

doi:10.1111/j.1651-2227.2001.tb00262.x

Cited by 37 publications

(22 citation statements)

References 12 publications

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“…It has been reported that increased responsiveness of rat immature enterocytes to insulin, usually seen at the onset of weaning in suckling animals, could be related to high membrane concentrations of the insulin receptor (19). However, the effects of oral insulin on gut maturation and intestinal mucosal enzyme expression have usually been demonstrated in suckling mice, rat, piglets, calves, and pigs (3,(17)(18)(19)(20). Furthermore, when insulin was given intraperitoneally to rats, the effects on intestinal cells was limited to suckling animals (7).…”

Section: Discussionmentioning

confidence: 98%

Intestinal and Systemic Effects of Oral Insulin Supplementation in Rats After Weaning

et al. 2005

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Oral insulin has intestinal trophic effects in suckling animals. In mice, lower glucose and lipid levels may be seen when oral insulin is given after the weaning period. The purpose of the present study is to examine local and systemic effects of oral insulin supplementation in rats in the postweaning period. Immediately after weaning, Sprague-Dawley rats received either drinking water (controls) or oral insulin in their drinking water (1 U/ml) for either 1 week or 6 weeks. Intestinal mucosal parameters (bowel and mucosal weight, mucosal DNA and protein) and histological changes were examined in all study groups. Glucose levels were monitored weekly, and at the end of the study, blood levels of glucose, lipids, and insulin were measured in the fasting state. After 1 week of insulin supplementation, mucosal weight in duodenum and jejunum as well as jejunal DNA content were significantly higher in insulin-supplemented rats compared to controls. Duodenal circumference and villus height in jejunum were significantly higher in insulin-supplemented rats compared to controls on both day 7 and day 42. Total cholesterol levels were significantly lower in the study group compared with the controls. We conclude that oral insulin supplementation exerts intestinal trophic effects, as well as systemic effects in the postweaning period in rats.

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Section: Discussionmentioning

confidence: 98%

Intestinal and Systemic Effects of Oral Insulin Supplementation in Rats After Weaning

et al. 2005

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“…However, the concentration of insulin in human milk is also significantly higher (60.23±41.05 micro unit/mL) whereas it is low in cow milk (16.32±5.98 micro unit/mL) (Shehadeh et al, 2001) but probably because of coagulation in stomach it is not available for absorption in the intestine. Intestinal absorption of large proteins and, therefore, insulin is only possible in the first few days of life (Lawrence and Lawrence, 2010).…”

Section: Discussionmentioning

confidence: 94%

Effects of Camels Milk as a Vehicle for Insulin on Glycaemic Control and Lipid Profile in Type 1 Diabetics

Sirirat¹

2011

American Journal of Biochemistry and Biotechnology

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Problem statement:To evaluate effects of oral insulin carried by camel's milk on type 1 diabetes patient in comparison with both insulin injection requirements and camel's milk alone. Approach: Total of fifty randomly selected type 1 diabetic subjects were divided into three groups; A, B and C (n = 15). All subjects received a usual care (diet, exercise and insulin injection) but group B subjects in addition received 500 mL day −1 of camel's milk, while group C their subjects in addition received insulin mixed with 500 ml day

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“…Diabetes mellitus interrupts normal child development and carries the threat of severe complications in the active period of their lives. It is therefore, urgently needed to search for safe and more effective therapies for DM, either as complementary or alternative to existing treatment programs as no drug has been shown to modify the course of diabetic complications [13,18].An alternative to current insulin treatment of DM is Camelusdromedarius milk [18][19][20][21][22][23][24][25][26][27][28]. Moreover, Camelusdromedarius milk has shown to have exceptional broad therapeutic qualities on other serious human diseases [24,[29][30][31][32].…”

Section: Introductionmentioning

confidence: 99%

An Overview of the Therapeutic Effects of Camel Milk in the Treatment of Type 1 Diabetes Mellitus

Ko¹

2014

J Biomol Res Ther

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The main treatment of type 1 diabetes mellitus (DM) is insulin replacement via parenteral routes, which is far from satisfactory. Camel milk is an alternative to current insulin treatment. This paper discusses the chemical constituents and properties of camel milk, recent experimental evidences about the effectiveness of camel milk in the treatment of insulin dependent diabetes mellitus, role of the camel milk in the restoration of damaged beta-cells of the pancreas and in the improvement of disturbed lipid metabolism associated with type 1 DM as well as the effects of camel milk in the improvement of clinical function parameters of the kidneys and liver of subjects with insulin dependent diabetes mellitus. This paper demonstrates that, camel milk causes significant reduction in insulin dosages in insulin dependent diabetic subjects to obtain glycemic control along with significant improvement in HbA1c level, and improvement in micro albuminuria. Significant improvements were also observed in lipid metabolism, body mass index (BMI), biochemical parameters of the liver and kidney functions of camel milk fed experimental subjects with type-1 diabetes. Camel milk works as a regulator of blood sugar in the absence of original insulin, and it seems to work together with the body's own restorative and regenerative abilities. Camel milk is well tolerated and its uses are not associated with an increase in hypoglycemic events. Camel milk may be able to eliminate the alloxan and other chemicals' induced-toxicity on pancreas and on other body organs via regenerative effects on damaged cells and could be used as a restorative treatment of diabetes.

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Importance of insulin content in infant diet: suggestion for a new infant formula

Cited by 37 publications

References 12 publications

Intestinal and Systemic Effects of Oral Insulin Supplementation in Rats After Weaning

Intestinal and Systemic Effects of Oral Insulin Supplementation in Rats After Weaning

Effects of Camels Milk as a Vehicle for Insulin on Glycaemic Control and Lipid Profile in Type 1 Diabetics

An Overview of the Therapeutic Effects of Camel Milk in the Treatment of Type 1 Diabetes Mellitus

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Importance of insulin content in infant diet: suggestion for a new infant formula

Cited by 37 publications

References 12 publications

Intestinal and Systemic Effects of Oral Insulin Supplementation in Rats After Weaning

Intestinal and Systemic Effects of Oral Insulin Supplementation in Rats After Weaning

Effects of Camels Milk as a Vehicle for Insulin on Glycaemic Control and Lipid Profile in Type 1 Diabetics

An Overview of the Therapeutic Effects of Camel Milk in the Treatment of Type 1 Diabetes Mellitus

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Product

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Effects of Camels Milk as a Vehicle for Insulin on Glycaemic Control and Lipid Profile in Type 1 Diabetics