Importance of Leuprolide Acetate Variable Dosing for Precocious Puberty: A Range of Acceptable Suppression

Cohen, Daniela; Janfaza, Mona; Klein, Karen Oerter

doi:10.1515/jpem.2009.22.7.629

Cited by 4 publications

(2 citation statements)

References 12 publications

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“…Lower doses were unable to suppress his gonadotropins to a prepubertal level. His dose was increased to 30 mg IM every 3 months because variable dosing of leuprolide has been shown to achieve adequate hormonal suppression [ 4 ]. He discontinued GnRH analog and aromatase inhibitor therapy at chronological age 10 years and 6 months at the request of his parents.…”

Section: Case Descriptionmentioning

confidence: 99%

A Case of Familial Male-Limited Precocious Puberty in a Child With Klinefelter Syndrome

Cornacchia

Bhushan

Arguello

2018

Journal of the Endocrine Society

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Familial male-limited precocious puberty (FMPP) is an autosomal dominant, male-limited disorder that causes peripheral precocious puberty in boys. Klinefelter syndrome (47, XXY) is the most common chromosomal aberration in males with associated infertility, hypogonadism, and learning disability. We report here a case of Klinefelter syndrome in a patient with FMPP. A 6-year-old boy was referred to our pediatric endocrinology department for accelerated linear growth and premature pubic hair development. He was diagnosed with FMPP based on clinical, laboratory, and genetic sequencing. Increased levels of gonadotropins prompted further investigation, leading to a subsequent diagnosis of Klinefelter syndrome through karyotype analysis. This case illustrates that patients with FMPP and elevated gonadotropins should encourage further investigation by physicians. We recommend the use of karyotype analysis in such patients who are not receiving aromatase inhibitor therapy. We hypothesize that his mutation or pretreatment with aromatase inhibitors may have a protective effect on testosterone production and sperm viability.

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Section: Case Descriptionmentioning

confidence: 99%

A Case of Familial Male-Limited Precocious Puberty in a Child With Klinefelter Syndrome

Cornacchia

Bhushan

Arguello

2018

Journal of the Endocrine Society

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“…Clinical, biological, anthropometric and radiographic evaluations are all helpful in distinguishing normal puberty from precocious puberty, which may have important clinical, psychological and therapeutic implications [12,13].…”

Section: Evaluation Of the Pubertal Stagementioning

confidence: 99%

Clinical Expression of Precocious Puberty in Girls

Sultan

Gaspari

Kalfa

et al. 2012

Endocrine Development

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Premature development of breast and/or pubic hair in a prepubertal girl used to raise questions and concerns from the families. There is actually a wide range of clinical expressions of precocious puberty in girls and not all presentations are considered to be true precocious puberty. Central precocious puberty occurs in 10-20% of girls, but beside the typical forms other clinical presentations have been identified. In 50-60% of the cases, only one secondary sex characteristic shows premature development and raises the diagnosis of premature thelarche, premature pubarche or isolated metrorrhagia. In 10% of the cases, autonomous ovarian overproduction of estrogens causes peripheral precocious puberty. Lastly, hyperestrogenism may have exogenous causes, such as exposure to environmental chemical pollutants. A decision on therapeutic management is based on clinical, biological and radiologic examinations, and LHRH analogous treatment should be limited to central precocious puberty before the age of 8 years.

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Current World Literature

2010

Current Opinion in Obstetrics &Amp; Gynecology

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Importance of Leuprolide Acetate Variable Dosing for Precocious Puberty: A Range of Acceptable Suppression

Abstract: Variable dosing of leuprolide acetate is needed to achieve similar amounts of hormonal suppression, yet small changes in dose did not significantly change LH or estradiol levels or predicted height.

Cited by 4 publications

References 12 publications

A Case of Familial Male-Limited Precocious Puberty in a Child With Klinefelter Syndrome

A Case of Familial Male-Limited Precocious Puberty in a Child With Klinefelter Syndrome

Clinical Expression of Precocious Puberty in Girls

Current World Literature

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