Importance of lipid ratios for predicting intracranial atherosclerotic stenosis

Abstract

<jats:title>Abstract</jats:title> <jats:p><jats:bold>Background: </jats:bold>This study aims<jats:bold> </jats:bold>to investigate the association of lipid ratios with intracranial atherosclerotic stenosis (ICAS) in a Chinese population.<jats:bold>Methods:</jats:bold> This cross-sectional study included 658 consecutive patients with ischemic stroke. Intracranial and extracranial arteries were evaluated for atherosclerotic stenosis using digital subtraction angiography or computed tomography angiography. Lipid ratios [total cholesterol (TC)/high-density lipoprotein-cholesterol (HDL-C), triglycerides (TG)/HDL-C, low-density lipoprotein-cholesterol (LDL-C)/HDL-C, non-high-density lipoprotein-cholesterol (non-HDL-C)/HDL-C, remnant cholesterol (RC)/HDL-C, apolipoprotein B (apo B)/apolipoprotein A-I (apo A-I), and apo B/HDL-C] were calculated.<jats:bold>Results: </jats:bold>The TC/HDL-C, LDL-C/HDL-C, RC/HDL-C, non-HDL-C/HDL-C, apo B/HDL-C and apo B/apo A-I ratios (all <jats:italic>P</jats:italic> &lt;0.05) were significantly associated with ICAS but not with extracranial atherosclerotic stenosis after adjustment for confounding factors. Receiver operating characteristic (ROC) curves analyses revealed that the apo B/apo A-I ratio had the largest area under the ROC curve (AUC) among lipid levels alone and for lipid ratios (AUC = 0.588). Lipid ratios had higher AUC values than those for lipid levels alone for the identification of ICAS.<jats:bold>Conclusion:</jats:bold> The TC/HDL-C, LDL-C/HDL-C, RC/HDL-C, non-HDL-C/HDL-C apo B/HDL-C, and apo B/apo A-I ratios were significantly related to ICAS risk. Compared with the other variables tested, the apo B/apo A-I ratio appeared to be a better discriminator for identifying ICAS risk in stroke patients.</jats:p>

Predictive effect of different blood lipid parameters combined with carotid intima-media thickness on coronary artery disease

“…Previous studies have shown that blood lipid indices, such as triglyceride/highdensity lipoprotein cholesterol (TG/HDL-C) ratio, apolipoprotein B/apolipoprotein A-I (Apo B/Apo A-I) ratio, total cholesterol (TC)/HDL-C ratio or low-density lipoprotein cholesterol (LDL-C)/HDL-C have a better predictive value of CAD than a single parameter (3)(4)(5)(6)(7)(8). Recent findings showed that blood lipid indices were significantly correlated with the risk of intracranial atherosclerotic stenosis and metabolic syndrome (9,10). The combination of lipid parameters represents relative status of blood lipids, which can comprehensively reflect the balance between atherosclerosis and anti-atherosclerosis and accurately assess lipid deposition (11,12).…”

Comparison of the Predictive Values of Different Lipid Parameters Combined with Carotid Intima-Media Thickness in Coronary Artery Disease

“…Previous studies have shown that blood lipid indices, such as triglyceride/high-density lipoprotein cholesterol (TG/HDL-C) ratio, apolipoprotein B/apolipoprotein A-I (Apo B/Apo A-I) ratio, total cholesterol (TC)/HDL-C ratio or low-density lipoprotein cholesterol (LDL-C)/HDL-C have a better predictive value of CAD than a single parameter [3][4][5][6][7][8]. Recent ndings showed that blood lipid indices were signi cantly correlated with the risk of intracranial atherosclerotic stenosis and metabolic syndrome [9][10]. The combination of lipid parameters represent relative status of blood lipids, which can comprehensively re ect the balance between atherosclerosis and anti-atherosclerosis and accurately assess lipid deposition [11][12].…”

Predictive Effect of Different Blood Lipid Parameters Combined with Carotid Intima-Media Thickness on Coronary Artery Disease

“…Previous studies have shown that blood lipid indices, such as triglyceride/high-density lipoprotein cholesterol (TG/HDL-C) ratio, apolipoprotein B/apolipoprotein A-I (Apo B/Apo A-I) ratio, total cholesterol (TC)/HDL-C ratio or low-density lipoprotein cholesterol (LDL-C)/HDL-C have a better predictive value of CAD than a single parameter [3][4][5][6][7][8]. Recent ndings showed that blood lipid indices were signi cantly correlated with the risk of intracranial atherosclerotic stenosis and metabolic syndrome [9][10]. The combination of lipid parameters represent relative status of blood lipids, which can comprehensively re ect the balance between atherosclerosis and anti-atherosclerosis and accurately assess lipid deposition [11][12].…”