Importance of &lt;sup&gt;123&lt;/sup&gt;I-Metaiodobenzylguanidine Scintigraphy/Single Photon Emission Computed Tomography for Diagnosis and Differential Diagnostics of Parkinson Syndromes

Jost, Wolfgang H.; Tredici, Kelly Del; Landvogt, Christian; Braune, Stefan

doi:10.1159/000314573

Cited by 27 publications

(31 citation statements)

References 113 publications

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“…The sensitivity and specificity of planar scintigraphy for the diagnosis of PD have been reported to be approximately 73.3-100 % and 54.5-100 %, respectively (Chung et al 2009;Sawada et al 2009;Jost et al 2010;Sudmeyer et al 2011;Watanabe et al 2011), which are similar to the results of this study.…”

Section: Discussionsupporting

confidence: 90%

Comparison of I-123 MIBG planar imaging and SPECT for the detection of decreased heart uptake in Parkinson disease

Choi

Song

et al. 2015

J Neural Transm

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Decreased myocardial uptake of I-123 metaiodobenzylguanidine (MIBG) is an important finding for diagnosis of Parkinson's disease (PD). This study compared I-123 MIBG SPECT and planar imaging with regard to their diagnostic yield for PD. 52 clinically diagnosed PD patients who also had decreased striatal uptake on FP-CIT PET/CT were enrolled. 16 normal controls were also included. All underwent cardiac MIBG planar scintigraphy and SPECT separately. Myocardial I-123 MIBG uptake was interpreted on planar and SPECT/CT images separately by visual and quantitative analysis. The final diagnosis was made by consensus between two readers. Kappa analyses were performed to determine inter-observer agreement for both methods. Sensitivity, specificity, and accuracy were compared with McNemar's test. The sensitivity, specificity, and accuracy were 84.6, 100, and 88.2% for planar images and 96.2, 100 and 97.1% for SPECT, respectively, with a significant difference between the two imaging methods (p < 0.031). All inter-observer agreements were almost perfect (planar scintigraphy: κ = 0.82; SPECT: κ = 0.93). Heart-to-mediastinum ratios from PD patients with negative planar and positive SPECT scans (group A) and patients with positive planar and positive SPECT scans (group B) were 1.69 ± 0.16 (1.59-1.85) and 1.41 ± 0.15 (1.20-1.53), respectively, and showed significant difference (p = 0.023). Lung-to-mediastinum ratios for groups A and B were 2.16 ± 0.20 (1.96-2.37) and 1.6 ± 0.19 (1.3-1.78), respectively, and were significantly higher in the former (p = 0.001). I-123 MIBG SPECT has a significantly higher diagnostic performance for PD than planar images. Increased lung uptake may cause false-negative results on planar imaging.

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Section: Discussionsupporting

confidence: 90%

Comparison of I-123 MIBG planar imaging and SPECT for the detection of decreased heart uptake in Parkinson disease

Choi

Song

et al. 2015

J Neural Transm

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“…Myocardial sympathetic innervation imaging using 123 Imetaiodobenzylguanidine (MIBG) has emerged as a useful method to confirm or exclude the presence of PD [1]. Radiolabeled MIBG is useful to study the organs richly innervated by the sympathetic nervous system.…”

Section: Introductionmentioning

confidence: 99%

MIBG scintigraphy in differential diagnosis of Parkinsonism: a meta-analysis

et al. 2011

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“…LBD present an impairment of adrenergic function and consequently an abnormal myocardial innervation imaging: the involvement of myocardial postganglionic sympathetic nerves may account for the reduction of myocardial mIBG uptake in patients with PD, as well as in patients with other LBD [39,41]. Also patients with idiopathic RBD usually present a reduction of myocardial mIBG uptake; RBD consists of a wide range of neurodegenerative disorders, but the pathological entity of idiopathic RBD has not yet been confirmed.…”

Section: The Role Of Cardiac Mibg Imaging In Pdmentioning

confidence: 99%

Neurological applications for myocardial MIBG scintigraphy

Cacace²,

Antonio³

et al. 2013

Nucl. Med. Rev.

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Signs or symptoms of impaired autonomic regulation of circulation are typically present in patients affected by Parkinson's disease (PD), in agreement with the cardiac sympathetic denervation discovered by Goldstein more than 15 yrs. ago.In particular, the majority of PD patients have a diffuse left ventricular myocardial sympathetic denervation, being a normal neurological condition present only in a small number of affected subjects. Actually MIBG cardiac imaging is a universally accepted method to estimate cardiac sympathetic innervations. This review covers the role of MIBG cardiac imaging in PD as well as in other parkinsonisms, focusing the attention on technical problems and pathophysiological premises for cardiac denervation. In particular new emerging data support the role of MIBG as biomarker of PD, also before motor symptoms became clinically evident. Therefore the timing of cardiac noradrenergic denervation in PD is a key issue and we want to update the analysis of autonomic cardiovascular abnormalities studied with MIBG in PD and related disorders.

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Importance of <sup>123</sup>I-Metaiodobenzylguanidine Scintigraphy/Single Photon Emission Computed Tomography for Diagnosis and Differential Diagnostics of Parkinson Syndromes

Cited by 27 publications

References 113 publications

Comparison of I-123 MIBG planar imaging and SPECT for the detection of decreased heart uptake in Parkinson disease

Comparison of I-123 MIBG planar imaging and SPECT for the detection of decreased heart uptake in Parkinson disease

MIBG scintigraphy in differential diagnosis of Parkinsonism: a meta-analysis

Neurological applications for myocardial MIBG scintigraphy

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