Importance of Monitoring Physical Function for Quality of Life Assessments in Hematopoietic Stem Cell Transplantation Patients: A Prospective Cohort Study

Kim, Inho; Koh, Youngil; Shin, Dong‐Yeop; Hong, Junshik; Jae, Hui; Kwon, So Hyun; Seo, Kwan Sik

doi:10.21873/invivo.11837

Cited by 14 publications

(10 citation statements)

References 24 publications

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“…Our study showed that impaired PF in the acute post-transplant period of HSCT during hospitalization occurs in over a third of the recipients, mainly in the rst week after HSCT. In our previous study with 41 participants, 24.40% of patients experienced a decline in PF after HSCT [20]. Few studies have investigated PF changes after HSCT during the inpatient period.…”

Section: Discussionmentioning

confidence: 91%

The Immediate Impact of Physical Function and Quality of Life After Hematopoietic Stem Cell Transplantation

Lee

Kim

Koh

et al. 2021

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Purpose: Although hematopoietic stem cell transplantation (HSCT) is a curative treatment for hematologic malignancies, HSCT survivors often experience declined physical function and quality of life (QoL). However, the physical function and QoL changes in acute posttransplant patients remain unclear. This study aimed to monitor changes in physical function and QoL after HSCT. Method: This retrospective controlled cohort study included 107 HSCT patients. Physical function was evaluated weekly from admission to discharge using the de Morton Mobility Index (DEMMI). Impaired physical function was defined as a baseline raw ordinal DEMMI score of < 17 and a decrease of ≥ 2 points. We collected the Visual Analogue Scale (VAS), European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30), and Zung Self-rating Depression Scale (SDS) at enrollment and discharge.Results: Based on the DEMMI scores, 41 patients (38.3%) showed impaired physical function. A notable decrease in the DEMMI score was found in the first week after HSCT. In the EORTC QLQ-C30, physical function differed between the groups at admission and discharge. The good physical function group showed better cognitive function and social function. For the SDS, the impaired physical function group showed significantly higher depression at discharge. Conclusion: A third of the patients showed physical impairment during the acute transplant period. Patients with low physical function suffered more from depression and lower QoL. Evaluating patients’ pretransplant physical function and early detection is needed as impaired physical function mainly occurs at 1 week post-transplant.

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Section: Discussionmentioning

confidence: 91%

The Immediate Impact of Physical Function and Quality of Life After Hematopoietic Stem Cell Transplantation

Lee

Kim

Koh

et al. 2021

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“…International studies show higher age means of the patients undergoing HSCT. Two South Korean studies have identified means over 48 years old (Kang et al, 2020;Kim et al, 2020). An Italian study found a mean of 50 years old (Biagioli et al, 2019), and a research study conducted in the United States found a mean of 56 years old (LaLonde et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

Guided imagery relaxation in quality of life of patients undergoing hematopoietic stem cell transplantation: a quasi-experiment

Silva

Machado

Santana

et al. 2021

Asian Pac J Cancer Prev

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Objective: The aim of this study was to evaluate the effects of the relaxation technique with guided imagery by means of virtual reality on health-related quality of life in patients undergoing hematopoietic stem cell transplantation. Methods: A quasi-experiment conducted in a Bone Marrow Transplantation Service of a public hospital in southern Brazil. From October 2019 to October 2020, forty-two adult participants who underwent transplantation were included, 35 in the intervention group and seven in the control group. A guided imagery intervention, with audio guiding the relaxation associated with nature images in 360º, was performed during the hospitalization period. Data were collected on the first day of hospitalization, on the transplantation day, during the neutropenia stage, and at pre-hospital discharge. The Functional Assessment of Cancer Therapy-Bone Marrow Transplantation (FACT-BMT), Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-Fatigue) and Functional Assessment of Cancer Therapy-Neutropenia (FACT-N) were used to assess health-related quality of life, fatigue and neutropenia. Data were analyzed using the Generalized Linear Mixed Model for the evolution of the health-related quality of life assessments over time, considering the groups and stages. Pearson's correlation coefficient was adopted for the correlation analyses. Results: Allogeneic transplantation was predominant: 28 (80%) in the intervention group and 5 (71.43%) in the control group. There were improvements in the health-related quality of life scores, although not significant. A significant difference was found among the stages (p<0.050) and a significant positive correlation (p<0.000) among the variables on general quality of life, additional concerns, fatigue and neutropenia in all stages. Conclusion: Patients undergoing hematopoietic stem cell transplantation suffer changes in their quality of life. Interventions based on integrative practices emerge as an option to minimize them.

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“…AHSCT is associated with health problems occurring in the immediate post-transplant period including infections, bleeding, mucositis, fever, nausea, hypotension and shock, skin rash, acute or chronic pain and diarrhea 4 which can negatively affect patients’ QoL and survival. 5 …”

Section: Introductionmentioning

confidence: 99%

“…3 AHSCT is associated with health problems occurring in the immediate post-transplant period including infections, bleeding, mucositis, fever, nausea, hypotension and shock, skin rash, acute or chronic pain and diarrhea 4 which can negatively affect patients' QoL and survival. 5 In addition, patients undergoing an AHSCT can present relevant psychological distress-most common depression, anxiety and sleeping problems-they might confront with primitive defence mechanisms such as denial, and projection. 6 Depression is the most common manifestation of psychological distress in patients with neoplastic disease; [7][8][9] which is even more frequent in patients with advanced disease.…”

mentioning

confidence: 99%

Impact of educational interventions on psychological distress during allogeneic hematopoietic stem cell transplantation: a randomized study.

Cioce¹,

Lohmeyer²,

Moroni³

et al. 2020

Mediterr J Hematol Infect Dis

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Background Physical and psychological factors, like wrong attitudes and behaviours, can negatively influence health outcomes of the patients receiving allogeneic hematopoietic stem cell transplantation (AHSCT). Educational interventions aiming to improve knowledge on side effects, risks, complications and preventive behaviour can reduce psychological distress, and improve quality of life (QoL). We aimed to compare a standard approach with therapeutic patient education (TPE) to analyse the impact on AHSCT patients’ QoL, psychological distress and knowledge of AHSCT side effects, risks complications and preventive behaviour. Material and methods A prospective interventional study was conducted analysing data of 36 patients who received one of two different educational approaches, which were a standard approach (not-exposed) or TPE (exposed). Results In the exposed group QoL improved 14 days after transplantation (42.2 vs 25.6; p<0.03) and at time of discharge (36.6 vs 54.4; p<0.005). Anxiety and depression was better controlled in the exposed group, both at hospitalization and discharge (anxiety: 48.1 vs 53.2; 46.4 vs 51.6. p<0.04; depression: 49 vs 55.3; 48 vs 54.3 , p<0.03). Knowledge of AHSCT risks and complications improved in exposed patients, both at admission (10.1/15 vs 8/15 correct answers; p<0.01) and discharge (10.7/15 vs 8.8/15 correct answer; p<0.03). Conclusion The TPE for AHSCT patients improved knowledge, reduced anxiety and depression, which consequently increasing QoL. Therefore, we recommend our approach to further engage patients in the treatment plan, which should specifically take place prior to AHSCT initiation.

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Importance of Monitoring Physical Function for Quality of Life Assessments in Hematopoietic Stem Cell Transplantation Patients: A Prospective Cohort Study

Cited by 14 publications

References 24 publications

The Immediate Impact of Physical Function and Quality of Life After Hematopoietic Stem Cell Transplantation

The Immediate Impact of Physical Function and Quality of Life After Hematopoietic Stem Cell Transplantation

Guided imagery relaxation in quality of life of patients undergoing hematopoietic stem cell transplantation: a quasi-experiment

Impact of educational interventions on psychological distress during allogeneic hematopoietic stem cell transplantation: a randomized study.

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