Importance of N⁶‑methyladenosine RNA modification in lung cancer (Review)

N6-methyladenosine reader YTHDF1 regulates the proliferation and migration of airway smooth muscle cells through m6A/cyclin D1 in asthma

“…Presently, m 6 A methylation gains more and more attention about its function and mechanism. In the asthma pathophysiological process, there is only primary probation and initiatory findings ( Wang et al, 2021 ; Wu et al, 2021 ). For example, Teng et al (2021) found that dysregulated or hypermethylated m 6 A peaks in 329 mRNAs and 150 hypomethylated m 6 A peaks in 143 mRNAs in asthmatic mice.…”

m6A demethylation of cytidine deaminase APOBEC3B mRNA orchestrates arsenic-induced mutagenesis

“…Among these m6A modulators, FTO is the first identified m6A demethylase that mediates m6A demethylation in the 3′-UTR and near stop codon region ( 20 ). FTO participates in diverse physiological and pathological processes, notably it plays an oncogenic role in a variety of cancers ( 21 , 22 ). It is reported that alteration of FTO expression is involved in metabolic starvation stress, acute liver injury, or heart failure ( 23 , 24 , 25 ).…”