Importance of Nutrient Availability and Metabolism for Skeletal Muscle Regeneration

Abstract

Skeletal muscle is fundamentally important for quality of life. Deterioration of skeletal muscle, such as that observed with advancing age, chronic disease, and dystrophies, is associated with metabolic and functional decline. Muscle stem/progenitor cells promote the maintenance of skeletal muscle composition (balance of muscle mass, fat, and fibrotic tissues) and are essential for the regenerative response to skeletal muscle damage. It is increasing recognized that nutrient and metabolic determinants of stem/progenitor cell function exist and are potential therapeutic targets to improve regenerative outcomes and muscle health. This review will focus on current understanding as well as key gaps in knowledge and challenges around identifying and understanding nutrient and metabolic determinants of skeletal muscle regeneration.

A Tale of Three Proteomes: Visualizing Protein and Transcript Abundance Relationships in the Breast Cancer Proteome Portal

“…Growth in the field continues at a rapid pace, while frontiers in high-throughput techniques develop in phosphoproteomics, proteogenomics, protein localization, and protein trafficking . Efficient application of targeted methodologies assessing hypotheses, such as purported metabolic function or protein interactions , will require accessible tools to explore applicable data sets. By gathering data from all comparable clinical proteomics-based breast cancer studies, the Breast Cancer Proteome Portal provides an essential resource for maximizing the efficacy of research into novel molecular targets to treat breast cancer.…”

Exercise and Caloric Restriction Exert Different Benefits on Skeletal Muscle Metabolism in Aging Condition

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