1997
DOI: 10.1016/s0167-8140(97)01904-x
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Importance of overall treatment time for the outcome of radiotherapy of advanced head and neck carcinoma: dependency on tumor differentiation

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Cited by 138 publications
(69 citation statements)
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“…Recently, it was suggested that well-differentiated carcinomas of the head and neck respond to a radiation trauma with accelerated repopulation just like the normal mucosa, and that these tumours may benefit from reduced overall treatment time (Hansen et al, 1997). In the present study, the poorly differentiated tumours appeared to be the most radiosensitive, measured by tumour cell SF 2 .…”
supporting
confidence: 46%
“…Recently, it was suggested that well-differentiated carcinomas of the head and neck respond to a radiation trauma with accelerated repopulation just like the normal mucosa, and that these tumours may benefit from reduced overall treatment time (Hansen et al, 1997). In the present study, the poorly differentiated tumours appeared to be the most radiosensitive, measured by tumour cell SF 2 .…”
supporting
confidence: 46%
“…Cluster 2 shows also a higher percentage of well-differentiated tumors with respect to the other clusters (Fig. 2); this agrees with a previous study suggesting that welldifferentiated tumors have a more pronounced treatment-time dependency (17). Profile 7 showed benefit also from CHART, but this result was not significant after a multiple test correction.…”
Section: Discussionsupporting
confidence: 90%
“…Well-differentiated squamous cell carcinoma has a shorter potential doubling time and a greater propensity for accelerated repopulation during radiotherapy than most other tumour types [53]. The experiences of the CHART and the DAHANCA studies tend to confirm the benefit of short overall treatment times for well differentiated compared with poorly differentiated squamous cell carcinomas [5,14]. Slevin at al.…”
Section: Discussionmentioning
confidence: 99%