Importance of Patients’ Knowledge of Their Prescribed Medication in Improving Treatment Adherence in Inflammatory Bowel Disease

Abstract

Younger age, longer intervals between outpatient clinic visits, and limited knowledge of the prescribed medication tended to be associated with nonadherence to treatment, which consequently also affects the risk of relapse.

Higher education, professional occupation, and upper socioeconomic status are associated with lower adherence to medications in patients with inflammatory bowel disease

“…A similar study conducted in a different part of the country reported opposite results, with 81% of the study population being nonadherent . Another study from Asia (Korea) reported adherence rates of 63.8% . In a systematic review of 17 studies (no Asian study), the nonadherence rates varied from 7 to 72%, and studies from Spain, Italy, Belgium, and Prague have reported adherence rates to IBD medications of 38, 64, 61, and 61%, respectively .…”

“…Less than 10% of patients in the present study belonged to high socioeconomic status, whereas most of the patients in the other Indian study belonged to middle/upper socioeconomic status, which could explain this discrepancy. Another study from Asia (Korea) associated nonadherence with younger age, longer intervals between outpatient clinic visits, and limited knowledge of prescribed medication . In addition, nonadherent patients had a significantly greater risk of relapse of IBD than adherent patients.…”

“…9 Another study from Asia (Korea) reported adherence rates of 63.8%. 25 In a systematic review of 17 studies (no Asian study), 12 the nonadherence rates varied from 7 to 72%, and studies from Spain, Italy, Belgium, and Prague have reported adherence rates to IBD medications of 38, 64, 61, and 61%, respectively. 17,18,26,27 A study from the United States had reported good compliance with infliximab (75%) compared to the other medications, including steroids (69%), immunomodulators (72%), 5-ASA (63%), and antibiotics (47%).…”

“…Another study from Asia (Korea) associated nonadherence with younger age, longer intervals between outpatient clinic visits, and limited knowledge of prescribed medication. 25 In addition, nonadherent patients had a significantly greater risk of relapse of IBD than adherent patients. In a systematic review of 17 studies, psychological distress, patients' beliefs about medications, and doctor-patient discordance were associated with nonadherence, whereas demographic, clinical, and treatment variables were not.…”

The impact of patient‐centered medical homes on medication adherence?

“…Medication adherence is particularly important in chronic disease management (Baroletti & Dell'Orfano, 2010;Franks, Burton, & Simpson, 2005;Khdour, Hawwa, Kidney, Smyth, & McElnay, 2012;Krass, Schieback, & Dhippayom, 2015;Monane, Bohn, Gurwitz, Glynn, & Avorn, 1994;Osterberg & Blaschke, 2005). There are multiple reasons patients may be nonadherent, including the costs of medications (Gadkari & McHorney, 2012;Mojtabai & Olfson, 2003), forgetfulness (Franks et al, 2005;Gadkari & McHorney, 2012), inadequate health literacy (Lindquist et al, 2012), and low levels of knowledge about the medications prescribed and the disease being treated (Khdour et al, 2012;Koster et al, 2015;Tae et al, 2016). A variety of interventions to improve medication adherence have been proposed (Nieuwlaat et al, 2008), including a number of patient-centered approaches (Mishra, Gioia, Childress, Barnet, & Webster, 2011;Roumie et al, 2011).…”