Importance of Probiotics in Human Health

Banerjee, Dibyendu; Jain, Tushar; Bose, Sagarika; Bhosale, Vivek

doi:10.1007/978-981-13-1123-9_23

Cited by 7 publications

(2 citation statements)

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“…A similar study has shown the improvement in the immune-responsive activities of T cells, macrophages and natural killer cells. Associated with chemotherapy and radiotherapy, Lacticasei bacilli reduced the amount of side effects [ 117 ].…”

Section: Microbiota and The Digestive Pathologymentioning

confidence: 99%

The Gut Microbiome and Its Implication in the Mucosal Digestive Disorders

et al. 2022

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The gastrointestinal (GI) tract is one of the most studied compartments of the human body as it hosts the largest microbial community including trillions of germs. The relationship between the human and its associated flora is complex, as the microbiome plays an important role in nutrition, metabolism and immune function. With a dynamic composition, influenced by many intrinsic and extrinsic factors, there is an equilibrium maintained in the composition of GI microbiota, translated as “eubiosis”. Any disruption of the microbiota leads to the development of different local and systemic diseases. This article reviews the human GI microbiome’s composition and function in healthy individuals as well as its involvement in the pathogenesis of different digestive disorders. It also highlights the possibility to consider flora manipulation a therapeutic option when treating GI diseases.

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Section: Microbiota and The Digestive Pathologymentioning

confidence: 99%

The Gut Microbiome and Its Implication in the Mucosal Digestive Disorders

et al. 2022

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“…The scientific literature sustains the use of probiotics in a broad range of pathologies (enteric-related ones being most studied) with positive results, in several ways of action (decreasing intestinal pH, lowering colonization and multiplication of pathogens, metabolites, boosting the host immune response, bind toxins) [ 10 , 19 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 ]. The main pathway by which probiotics influence human health is their ability to protect and ensure good function of the gut epithelium by (i) direct influence on the epithelium—mucin expression and secretion by goblet cells and increase β-defensin secretion by the epithelial cells; (ii) increase mucosal immunity—increasing IgA-producing cells; and (iii) reduce pathogens numbers and/or their gene expression [ 15 , 30 ].…”

Section: Probiotics In Human Health and Microbiota Modulationmentioning

confidence: 99%

Biodetoxification and Protective Properties of Probiotics

2022

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Probiotic consumption is recognized as being generally safe and correlates with multiple and valuable health benefits. However, the mechanism by which it helps detoxify the body and its anti-carcinogenic and antimutagenic potential is less discussed. A widely known fact is that globalization and mass food production/cultivation make it impossible to keep all possible risks under control. Scientists associate the multitude of diseases in the days when we live with these risks that threaten the population’s safety in terms of food. This review aims to explore whether the use of probiotics may be a safe, economically viable, and versatile tool in biodetoxification despite the numerous risks associated with food and the limited possibility to evaluate the contaminants. Based on scientific data, this paper focuses on the aspects mentioned above and demonstrates the probiotics’ possible risks, as well as their anti-carcinogenic and antimutagenic potential. After reviewing the probiotic capacity to react with pathogens, fungi infection, mycotoxins, acrylamide toxicity, benzopyrene, and heavy metals, we can conclude that the specific probiotic strain and probiotic combinations bring significant health outcomes. Furthermore, the biodetoxification maximization process can be performed using probiotic-bioactive compound association.

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