Importance of Proliferation Markers in Oral Pathology

Warnakulasuriya, K. A. A. S.; Johnson, Newell W.

doi:10.1007/978-3-642-80169-3_5

Cited by 11 publications

(7 citation statements)

References 131 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A review of the range of methods of measuring cell proliferation of oral mucosa (Warnakulasuriya & Johnson 1996) suggests that immunohistochemistical detection of Ki67 can be used as an operational marker to label cycling cells at this site. Before the advent of immune markers, Walker's group (Walker & Dolby 1974) determined in vitro tritiated thymidine labelling index of lichen planus.…”

Section: Discussionmentioning

confidence: 99%

Epithelial cell proliferation in oral lichen planus

et al. 2002

Self Cite

View full text Add to dashboard Cite

Although the pathogenesis of oral lichen planus (OLP) is not clear, a small proportion of cases with OLP are reported to transform to cancer. We examined the epithelial cell proliferation status of OLP to relate the labelling index to microscopic features surveyed routinely in pathology. Mucosal biopsies obtained from 44 cases diagnosed with OLP with an intact oral epithelium and 10 normal control specimens from Japanese subjects were immunohistochemically stained with MIB and p53 antibodies. The Ki67 labelling index (LI) was significantly higher in OLP compared with normal controls. A particularly large number of OLP lesions (64%) were p53 positive. No association was, however, found with p53 expression and the Ki67 LI. Atrophic and flat epithelia had a quantitatively higher LI, which did not significantly differ from acanthotic biopsies. Increased cell proliferation in OLP is likely to be a secondary phenomenon due to the damage inflicted on keratinocytes by infiltrating mononuclear cells in the submucosa.

show abstract

Section: Discussionmentioning

confidence: 99%

Epithelial cell proliferation in oral lichen planus

et al. 2002

Self Cite

View full text Add to dashboard Cite

show abstract

“…The concern in a study such as this however, is that the length of the labeling opportunity for S‐phase and apoptosis might be different. This is because the length of the window of detection is directly proportional to the size of the fraction of the total population of cells undergoing apoptosis or division that is visible at any given time (Warnakulasuriya and Johnson, 1996). S‐Phase for most cell types is generally regarded as approximately 8 hr in duration (King, 1996).…”

Section: Discussionmentioning

confidence: 99%

Dynamics of parenchymal cell division, differentiation, and apoptosis in the young adult female mouse submandibular gland

Denny

1999

Anat. Rec.

View full text Add to dashboard Cite

The submandibular salivary gland of the young adult female mouse has two secretory cell types, acinar and granular duct, which are separated by intercalated ducts. Based on the occurrence of autologous cell division in these cells, they have been traditionally classified as expanding populations. However, differentiation from stem or progenitor cells in the intercalated ducts, usually associated with renewing populations, has also been detected. The question of renewing or expanding populations is resolved by quantitating and integrating the rates of autologous cell division, differentiation , and apoptosis for each cell type. The integrated data shows that both acinar and granular duct cell populations exhibit a substantial positive growth index, whereas the growth index for the intercalated duct cells is moderately negative. On balance, it suggests that the submandibular gland of the young adult female mouse is still growing. Comparison of young female mice with older females suggests that, although overall parenchymal growth slows with age, there is no longer a net loss of intercalated duct cells. Comparison with young adult male submandibular glands indicates that gender differences exist in the rates and mechanisms used for maintaining the different cell populations. The acinar and granular duct cell populations in young adult female mouse submandibular glands are expanding at the expense of the interca-lated duct cell population, which appears to be contracting. Anat Rec 254:408-417, 1999.

show abstract

“…Lack of clearly defined gate‐keeping genes for this site has hampered progress in identifying early biomarkers of progression. Of the available biomarkers26, one would expect those identifying genomic status and cell proliferation to correspond closely to the cellular and tissue changes observed in dysplasia27. The study bySudbø et al 15.…”

Section: A Classification Of Precancerous Lesions and Conditions Of Tmentioning

confidence: 99%

Histological grading of oral epithelial dysplasia: revisited

Warnakulasuriya

2001

J. Pathol.

111

View full text Add to dashboard Cite

Treatment of oral precancer is largely based on histological grading of epithelial dysplasia, despite the fact that this estimation is subjective and therefore carries a low reproducibility. The grade of epithelial dysplasia may not be proportional to the risk of malignant potential and clinical characteristics may complement therapeutic decisions. Molecular genetic changes found in oral epithelial dysplasia remain unclear and at present lack clinical significance. Genomic and proliferation markers are likely to be associated with histopathological parameters, but their relationship with the grading of dysplasia remains uncertain. They are potential biomarker candidates but their utility in prognosis of oral precancer deserves further study.

show abstract

Importance of Proliferation Markers in Oral Pathology

Cited by 11 publications

References 131 publications

Epithelial cell proliferation in oral lichen planus

Epithelial cell proliferation in oral lichen planus

Dynamics of parenchymal cell division, differentiation, and apoptosis in the young adult female mouse submandibular gland

Histological grading of oral epithelial dysplasia: revisited

Contact Info

Product

Resources

About