Importance of Prostatic Specific Antigen (Psa) in Clinical Practice : Our Experience

Chopra, GS; Bindal, Rajesh K.; Kotwal, Sanjeev; Rai, Ramji; Bhardwaj, Jagariti

doi:10.1016/s0377-1237(17)30546-4

Cited by 2 publications

(2 citation statements)

References 12 publications

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“…Chopra GS et at in their study stated that in 48 cases of carcinoma prostate PSA level ranged from 8.4 to 260 ng/mL with mean 74.75 ± 59.39 ng/mL and in BPH PSA levels ranged from 0.2 to 14.5 ng/mL (mean 4.66 ± 3.85). 13 Up till now, the Gleason score and grade groups are strong predictors for disease progression, and the most important parameters in therapeutic decision-making. 14 In our study, 50% of cases showed Gleason's score 9 followed by Gleason's score 7 (23%) and score 8 (17%).…”

Section: Discussionmentioning

confidence: 99%

Immunohistochemistry analysis of estrogen receptor and androgen receptor in benign prostatic hyperplasia and prostate carcinoma

Aditi¹,

Naik²

2023

JDPO

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Benign prostatic hyperplasia (BPH) and prostate adenocarcinoma are the most common disorders affecting elderly men. The diseases are androgen-dependent and are treated by obstructing androgen receptor (AR) or their action. AR has direct relationship between the development of prostatic hyperplasia and prostatic carcinoma. Estrogens directly target prostate tissue by definite estrogen receptors (ER). The human prostate is primed with a dual system of ERs (ER-α and ER-β). Use of estrogens as hormonal agents is for suppressing prostatic tissue growth. Study aims to identify, assess and establish the significance of ER and AR as a marker in distinguishing BPH and prostatic carcinoma. A cross sectional study was conducted at a tertiary care hospital over a period of two year on 65 specimens which included 30 malignant cases and 35 benign cases. Specimens received were tru-cut biopsy, transurethral resection of prostate chips (TURP) and prostatectomy specimen for malignant cases and TURP for benign lesions. Paraffin embedded blocks was stained with H&E and IHC with ER and AR performed on representative sections and graded .the results were assessed for association with various parameters in both benign and malignant cases. Out of 30 cases of adenocarcinoma of prostate majority of specimens were needle biopsies (54%). The age of presentation was 55-84 years with mean age being 68.93 years. In cases of BPH the presenting age was 35-84 years and mean age was 63 years. Histopathological parameters assessed for malignant lesions, showed negative correlation of grade group with PNI and positive correlation with neutrophils. Higher grade showed adverse histological parameters. %PSA was <25% in malignancy. ER positivity was noted in 80% malignant and 100% benign cases with weaker positivity noted maximum in benign cases. AR positivity was noted in all cases both benign and malignant, with benign cases showing higher intensity. Hormones play a multifactorial role in the pathogenesis of BPH and prostatic carcinoma; most commonly androgen and estrogen, and can be used towards finding a better therapy.

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Section: Discussionmentioning

confidence: 99%

Immunohistochemistry analysis of estrogen receptor and androgen receptor in benign prostatic hyperplasia and prostate carcinoma

Aditi¹,

Naik²

2023

JDPO

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“…The GLOBOCAN 2018 report estimated that there would be approximately 1.3 million new prostate cancer cases and 359,000 related deaths globally in 2018, which led to PCa being classified as the second most frequent cancer and the fifth leading cause of cancer deaths among men [4]. Also, the report demonstrated that about two-thirds of the newly diagnosed cases will be determined in the countries with very high developing index, where only 18% of the world’s male population resides [5, 6].…”

Section: Introductionmentioning

confidence: 99%

A correlation study of BK Polyoma Virus infection and prostate Cancer among Sudanese patients - immunofluorescence and molecular based case-control study

Gorish

Ournasseir

Shammat

2019

Infect Agents Cancer

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Background Polyomavirus hominis1, also called BK virus (BKV) is a well-known etiological agent of renal transplant nephropathy and cystitis. Recently, it got great attention from the researcher as a principal predisposing factor for different kinds of cancers including prostate cancer (PCa). Thus, this study aims to determine the correlation between BKV infection and PCa through a descriptive case-control based study. Methods A total of 55 paraffin-embedded tissue blocks of patients with PCa and another 55 tissue blocks from BPH patients were obtained. In parallel, respective urine samples were collected from all the cases and controls. The existence of BKV large T antigen (LTAg) was analyzed by Direct Immunofluorescence assay. Only BKV LTAg positive specimens were further analyzed for the presence of viral DNA by using a conventional PCR then subjected to viral load quantitation by using Q-PCR. Result BKV LTAg was identified in 30% (17/55) of cases tissue specimens and only in 7% (4/55) of the controls tissue specimens with P-value 0.002 and Odd ratio 5.7. The conventional PCR detects the BKV DNA in 16 out of 17 cases specimens while only two out of four controls specimens were identified with a viral DNA. The mean of the BKV DNA load was higher significantly among cases 6733 ± 6745 copies/ml when compared to controls 509.0 ± 792.9 copies/m with a p-value of 0.002. Conclusion More BKV prevalence with high viral load was observed in PCa patients tissue compared to BPH specimens. PCa Gleason scores 9 and 7 were the most cancer grades identified with the presence of BKV DNA. Our findings are thus consistent with a significant link between the BKV infection and the PCa risk. Prostate or seminal fluids should be selected as principal specimens for future studies and can, therefore, be designated as screening samples to find early virus evidence in the prostate tissue. Detection of early virus evidence may help to reduce the risk of PCa cancer due to BKV.

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Importance of Prostatic Specific Antigen (Psa) in Clinical Practice : Our Experience

Cited by 2 publications

References 12 publications

Immunohistochemistry analysis of estrogen receptor and androgen receptor in benign prostatic hyperplasia and prostate carcinoma

Immunohistochemistry analysis of estrogen receptor and androgen receptor in benign prostatic hyperplasia and prostate carcinoma

A correlation study of BK Polyoma Virus infection and prostate Cancer among Sudanese patients - immunofluorescence and molecular based case-control study

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