Importance of Sebaceous Glands in Cutaneous Penetration of an Antiandrogen: Target Effect of Liposomes

Bernard, Emmanuelle; Dubois, Jean‐Luc; Wépierre, J.

doi:10.1021/js960394l

Cited by 65 publications

(35 citation statements)

References 22 publications

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“…4) Although these reports described the whitening effect of LA in transdermal application, and the stabilization of LA by liposomal formulation, it was not confirmed whether LA encapsulated in liposomes enhanced the skin whitening effect. There have been number of reports that describe transdermal application using liposomes on cutaneous absorption, [5][6][7] on the transdermal delivey of encapsulated drugs 8) and on effective interaction of dermal skin cells with liposomes containing drugs in liposomes. [9][10][11] The synergistic effect of liposomes on active reagents for whitening via transdermal application was also reported.…”

mentioning

confidence: 99%

Skin Whitening Effect of Linoleic Acid Is Enhanced by Liposomal Formulations

Shigeta

Imanaka²,

Ando³

et al. 2004

Biological & Pharmaceutical Bulletin

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Hyperpigmentation on faces is a highly anxiety-producing symptom, especially for women from the aspect of beauty. We previously reported the skin whitening effect of linoleic acid (LA), 1,2) the mechanism of the whitening effect involving a decrease in tyrosinase level by LA, 3) and clinical trials of liposomal LA for skin hyperpigmentary disorders, such as melasma.4) Although these reports described the whitening effect of LA in transdermal application, and the stabilization of LA by liposomal formulation, it was not confirmed whether LA encapsulated in liposomes enhanced the skin whitening effect. There have been number of reports that describe transdermal application using liposomes on cutaneous absorption, 5-7) on the transdermal delivey of encapsulated drugs 8) and on effective interaction of dermal skin cells with liposomes containing drugs in liposomes.9-11) The synergistic effect of liposomes on active reagents for whitening via transdermal application was also reported.12) Compared to those reagents previously reported, LA is not only effective in whitening but also quite safe.13) Although there are many examples of the transdermal applications of liposomal formulations, little is known about the enhancement of drug efficacy by liposomalization. From this point of view, we were interested in the possible enhancement of LA's whitening activity by encapsulating it in liposomes. The present study clearly demonstrated that LA encapsulation in liposomes significantly enhanced it's whitening efficacy by transdermal application for UV-induced hyperpigmented dorsal skin of brownish guinea pigs. We also observed enhanced whitening efficacy by liposomalization of LA in UV-induced hyperpigmented human skin. MATERIALS AND METHODSWhitening Assay UVB-induced hyperpigmentation was elicited on the backs of brownish guinea pigs weighing about 600 g each (Saitama Experimental Animal Supply Co., Japan) using a modification of the method reported by Imokawa et al.14) Guinea pigs were gently tethered, and four separate areas (2.5 cmϫ2 cm) on the back of each animal were exposed to UVB radiation (ToRex FL20S-E-30/DMR, Toshiba, Japan) three times a week (every other day) for two consecutive weeks. The UVB intensity was 2 mW/cm 2 , and total energy dose was 1 J/cm 2 per exposure. Groups of six or more animals were used in each experiment. The animals were then left for an additional week to allow the UVBinduced hyperpigmentation to stabilize. Test samples were then topically applied daily to the hyperpigmented areas (0.01 ml/cm 2 ) five times per week for 3 successive weeks. The degree of pigmentation was assessed as the L-value measured with a chromameter (CR-200, Minolta, Japan) once every week from the beginning of sample application. The animals were cared for according to the guidelines for the Care and Use of Laboratory Animals of the University of Shizuoka.In the case of human skin assay, persons being tested were 6 healthy men in their 20 s or 30 s. After obtaining informed consents from the volunteers, UVB-induced hyp...

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confidence: 99%

Skin Whitening Effect of Linoleic Acid Is Enhanced by Liposomal Formulations

Shigeta

Imanaka²,

Ando³

et al. 2004

Biological & Pharmaceutical Bulletin

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“…Bernard et al [95] demonstrated SLNs can be employed for follicular delivery of various antiandrogens. They showed that antiandrogenic RU-58841 loaded in liposomes displayed much deeper penetration into the hair follicles [96].…”

Section: Targeting Of Sebaceous Glandsmentioning

confidence: 99%

Therapeutic and Diagnostic Applications of Nanotechnology in Dermatology and Cosmetics

Arif¹,

Nisa²,

Amin³

et al. 2015

J Nanomedine Biotherapeutic Discov

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Nanoscience is the branch of science pertaining to the study of minute particles on an atomic or molecular scale, whose size is measured in nanometers. A nanometer represents one billionth of a meter (i.e., 10 -9 m). Nanotechnology is an emerging branch of engineering that involves the use of particles on a nanoscale (1-100 nm). Thus, the application of nanotechnology in the field of dermatology is the Nanodermatology. Nanodermatology represents one of the most emerging fields for which an increasing interest is rising among scientists as well as pharmaceutical companies. Nanotechnology has revolutionized the treatment of several skin diseases. It is effective in targeted delivery of active medicaments and cosmetic ingredients. The skin forms the first point of contact for a diverse number of nanomaterials. Nanomedicine in dermatology has opened a new era in the diagnosis and treatment of various skin disorders. Possible applications of nanotechnology in dermatology and cosmetics include sunscreens, moisturizers, anti-aging formulations, phototherapy, anti-sepsis, vaccines, skin cancers, hair and nail care, etc. In this review after an introduction of nanotechnology, authors have described various types of nanoparticles followed by various possible indications of nanotechnology in dermatology and cosmetics. An account on safety of nanoparticles has also been added to the review. properties. Various other agents including vitamins (Vit. A, E, and K) and certain antioxidants like Carotenoids, lycopene, etc have been introduced in liposomes. These increase the physical and chemical stability of liposomes when dispersed in water [12]. Due to their biocompatible, biodegradable and nontoxic nature, liposomes find uses in a variety of cosmeceuticals as they encapsulate active moiety easily [11]. When associated to medication; liposomes ensure a high penetration into hair follicles [13]. Solid lipid nanoparticles (SLN)SLNs are colloidal carriers with size varying from 50 nm to 1000 nm. In these particles, Lipids (physiological lipids) are dispersed in an aqueous solution of surfactant or water [14]. SLNs possess various favourable properties viz., a) Presence of physiological and biodegradable lipids with low toxicity b) Occlusive properties which increase skin moisture level, c) Having a small size which ensures increased penetration of active ingredients, and d) Possessing characteristics of physical sunscreens of their own. These properties have made them popular in cosmetics [15,16]. SLNs have also been employed as topical vehicles for perfumes. When perfumes or fragrances are incorporated in SLNs, their release is delayed giving a prolonged effect of the perfume [17]. Nanostructured lipid carrier (NLC)NLC particles are manufactured by using blends of solid lipids with oils (liquid lipids).The solid lipid component is usually kept in a ratio of 70:30 while for oils, the preferred ratio is 99.9: 0.1. The overall melting point of such formulations decrease in comparison to the pure solid lipid which can be exp...

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“…Hueber et al [157] suggested that the sebaceous glands specifically promoted the penetration of hydrocortisone and testosterone into the skin. Evidence suggests that topically applied compounds entrapped in liposomes accumulated not only in the HF, but also in the sebaceous glands [159]. While the presence of lipophilic sebum may favor follicular uptake of lipophilic molecules, sebum production may, however, moderate drug transport, especially for hydrophilic drugs, functioning as a physical and a chemical barrier for drug penetration [160].…”

Section: Treatments Of Hair Growth Disorders: Room For Improvementmentioning

confidence: 99%

Biology of Human Hair: Know Your Hair to Control It

Araújo

Fernandes

Cavaco‐Paulo

et al. 2010

Advances in Biochemical Engineering/Biotechnology

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Hair can be engineered at different levels-its structure and surfacethrough modification of its constituent molecules, in particular proteins, but also the hair follicle (HF) can be genetically altered, in particular with the advent of siRNA-based applications. General aspects of hair biology are reviewed, as well as the most recent contributions to understanding hair pigmentation and the regulation of hair development. Focus will also be placed on the techniques developed specifically for delivering compounds of varying chemical nature to the HF, indicating methods for genetic/biochemical modulation of HF components for the treatment of hair diseases. Finally, hair fiber structure and chemical characteristics will be discussed as targets for keratin surface functionalization.

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Importance of Sebaceous Glands in Cutaneous Penetration of an Antiandrogen: Target Effect of Liposomes

Cited by 65 publications

References 22 publications

Skin Whitening Effect of Linoleic Acid Is Enhanced by Liposomal Formulations

Skin Whitening Effect of Linoleic Acid Is Enhanced by Liposomal Formulations

Therapeutic and Diagnostic Applications of Nanotechnology in Dermatology and Cosmetics

Biology of Human Hair: Know Your Hair to Control It

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