Importance of selenium for the influence of ischemia-reperfusion syndrome after kidney transplantation from a non-heart beating donor in a pig model

Třeška, Vladislav; Kuntscher, V; Hasman, D; Neprasová, P; Kobr, J; Ráček, Jaroslav; Trefil, Ladislav; Hes, Ondřej

doi:10.1016/s0041-1345(02)03694-1

Cited by 18 publications

(4 citation statements)

References 13 publications

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“…Also, several experimental studies showed improved kidney function after Se supplementation in AKI induced by cisplatin (Matés, 2000), and by gentamycin (Randjelovic et al, 2012). Selenium upregulated antioxidants in a pig model of transplanted kidneys (IRI) (Třeška et al, 2002).…”

Section: Survey Methodologymentioning

confidence: 99%

Oxidative stress as a potential target in acute kidney injury

Tomşa

Alexa

Junie

et al. 2019

PeerJ

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BackgroundAcute kidney injury (AKI) is a major problem for health systems being directly related to short and long-term morbidity and mortality. In the last years, the incidence of AKI has been increasing. AKI and chronic kidney disease (CKD) are closely interconnected, with a growing rate of CKD linked to repeated and severe episodes of AKI. AKI and CKD can occur also secondary to imbalanced oxidative stress (OS) reactions, inflammation, and apoptosis. The kidney is particularly sensitive to OS. OS is known as a crucial pathogenetic factor in cellular damage, with a direct role in initiation, development, and progression of AKI. The aim of this review is to focus on the pathogenetic role of OS in AKI in order to gain a better understanding. We exposed the potential relationships between OS and the perturbation of renal function and we also presented the redox-dependent factors that can contribute to early kidney injury. In the last decades, promising advances have been made in understanding the pathophysiology of AKI and its consequences, but more studies are needed in order to develop new therapies that can address OS and oxidative damage in early stages of AKI.MethodsWe searched PubMed for relevant articles published up to May 2019. In this review we incorporated data from different types of studies, including observational and experimental, both in vivo and in vitro, studies that provided information about OS in the pathophysiology of AKI.ResultsThe results show that OS plays a major key role in the initiation and development of AKI, providing the chance to find new targets that can be therapeutically addressed.DiscussionAcute kidney injury represents a major health issue that is still not fully understood. Research in this area still provides new useful data that can help obtain a better management of the patient. OS represents a major focus point in many studies, and a better understanding of its implications in AKI might offer the chance to fight new therapeutic strategies.

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Section: Survey Methodologymentioning

confidence: 99%

Oxidative stress as a potential target in acute kidney injury

Tomşa

Alexa

Junie

et al. 2019

PeerJ

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“…In extension to these therapeutic possibilities, there is experimental evidence that antioxidant treatment may ameliorate organ function after transplantation [ 125 ]. It would therefore be interesting to further elucidate whether patients with heart transplantation and exposure to an overwhelming inflammatory response in the period post-transplantation, might benefit from selenium supplementation.…”

Section: Future Directions and Therapeutic Implicationsmentioning

confidence: 99%

Selenium and Its Supplementation in Cardiovascular Disease—What do We Know?

et al. 2015

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The trace element selenium is of high importance for many of the body’s regulatory and metabolic functions. Balanced selenium levels are essential, whereas dysregulation can cause harm. A rapidly increasing number of studies characterizes the wide range of selenium dependent functions in the human body and elucidates the complex and multiple physiological and pathophysiological interactions of selenium and selenoproteins. For the majority of selenium dependent enzymes, several biological functions have already been identified, like regulation of the inflammatory response, antioxidant properties and the proliferation/differentiation of immune cells. Although the potential role of selenium in the development and progression of cardiovascular disease has been investigated for decades, both observational and interventional studies of selenium supplementation remain inconclusive and are considered in this review. This review covers current knowledge of the role of selenium and selenoproteins in the human body and its functional role in the cardiovascular system. The relationships between selenium intake/status and various health outcomes, in particular cardiomyopathy, myocardial ischemia/infarction and reperfusion injury are reviewed. We describe, in depth, selenium as a biomarker in coronary heart disease and highlight the significance of selenium supplementation for patients undergoing cardiac surgery.

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“…The benefits of selenium supplementation in improving the body’s selenium status has been highlighted in numerous selenium-deficient animal models as well as human trials [29,30,31,32]. In particular, therapeutic selenium administration has been shown as beneficial in several in vivo disease models where oxidative stress is prominent, including atherosclerosis [33,34,35,36] and various I/R pathologies such as renal and liver I/R injury [37,38]. The promise of selenium supplementation as a suitable therapeutic agent for the prevention of CVD is shown by the association of low selenium levels with the incidence of CVD [39,40,41] with low plasma concentrations of selenium associated with poor clinical outcome, accompanying future CVD deaths in ACS patients [40].…”

Section: Introductionmentioning

confidence: 99%

Assessing the Efficacy of Dietary Selenomethionine Supplementation in the Setting of Cardiac Ischemia/Reperfusion Injury

et al. 2019

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Oxidative stress is a major hallmark of cardiac ischemia/reperfusion (I/R) injury. This partly arises from the presence of activated phagocytes releasing myeloperoxidase (MPO) and its production of hypochlorous acid (HOCl). The dietary supplement selenomethionine (SeMet) has been shown to bolster endogenous antioxidant processes as well as readily react with MPO-derived oxidants. The aim of this study was to assess whether supplementation with SeMet could modulate the extent of cellular damage observed in an in vitro cardiac myocyte model exposed to (patho)-physiological levels of HOCl and an in vivo rat model of cardiac I/R injury. Exposure of the H9c2 cardiac myoblast cell line to HOCl resulted in a dose-dependent increase in necrotic cell death, which could be prevented by SeMet supplementation and was attributed to SeMet preventing the HOCl-induced loss of mitochondrial inner trans-membrane potential, and the associated cytosolic calcium accumulation. This protection was credited primarily to the direct oxidant scavenging ability of SeMet, with a minor contribution arising from the ability of SeMet to bolster cardiac myoblast glutathione peroxidase (GPx) activity. In vivo, a significant increase in selenium levels in the plasma and heart tissue were seen in male Wistar rats fed a diet supplemented with 2 mg kg−1 SeMet compared to controls. However, SeMet-supplementation demonstrated only limited improvement in heart function and did not result in better heart remodelling following I/R injury. These data indicate that SeMet supplementation is of potential benefit within pathological settings where excessive HOCl is known to be generated but has limited efficacy as a therapeutic agent for the treatment of heart attack.

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Importance of selenium for the influence of ischemia-reperfusion syndrome after kidney transplantation from a non-heart beating donor in a pig model

Cited by 18 publications

References 13 publications

Oxidative stress as a potential target in acute kidney injury

Oxidative stress as a potential target in acute kidney injury

Selenium and Its Supplementation in Cardiovascular Disease—What do We Know?

Assessing the Efficacy of Dietary Selenomethionine Supplementation in the Setting of Cardiac Ischemia/Reperfusion Injury

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