Importance of sperm gluthatione treatment in ART

Meybodi, Anahita Mohseni; Mozdarani, Hossein; Moradi, Saeed; Akhoond, Mohammad Reza

doi:10.1007/s10815-012-9755-5

Cited by 5 publications

(2 citation statements)

References 22 publications

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“…60 Recently, Meybodi et al demonstrated in an animal study that glutathione treatment might increase ART outcomes. 61 They found that glutathionetreated spermatozoa exhibited higher oocyte penetration rates.…”

Section: Glutathionementioning

confidence: 99%

Medical Management of Male Infertility in the Absence of a Specific Etiology

Güdeloğlu¹,

Brahmbhatt

Parekattıl

2014

Semin Reprod Med

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Idiopathic male infertility can be diagnosis in approximately one-third of infertile males. The empirical medical treatment with or without assisted reproductive techniques appears common in male infertility practice. This type of management can be classified as hormonal treatment including gonadotropins, antiestrogens, and aromatase inhibitors and support with antioxidant supplements such as carnitine, lycopene, glutathione, and vitamin E. This review investigates the evidence of commonly used empirical medical management of male infertility when there is no demonstrable diagnosis.

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Section: Glutathionementioning

confidence: 99%

Medical Management of Male Infertility in the Absence of a Specific Etiology

Güdeloğlu¹,

Brahmbhatt

Parekattıl

2014

Semin Reprod Med

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“…Asthenozoospermic sperm expressed some down-regulated antioxidative genes [ 6 ]. OS is accepted as the target for clinical treatment of asthenozoospermia [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

A novel posttranslational modification of histone, H3 S-sulfhydration, is down-regulated in asthenozoospermic sperm

Pan

Jiang

et al. 2021

J Assist Reprod Genet

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Oxidative stress is one of the major causes leading to male infertility including asthenozoospermia. Hydrogen sulfide (H2S) has been widely recognized to be a potent antioxidant whose role is partially implemented by protein S-sulfhydration. However, protein S-sulfhydration has not been reported in germ cells. Therefore, we investigated whether asthenozoospermia could be associated with sperm protein S-sulfhydration. S-sulfhydrated proteins in human sperm were enriched via biotin-switch assay and analyzed using LC-MS/MS spectrometry. Two hundred forty-four S-sulfhydrated proteins were identified. Importantly, we validated that sperm histones H3.1 and H3.3 were the S-sulfhydrated proteins. Their S-sulfhydrated amino acid residue was Cysteine111. Abundances of S-sulfhydrated H3 (sH3) and S-sulfhydrated H3.3 (sH3.3) were significantly down-regulated in asthenozoospermic sperm, compared with the fertile controls, and were significantly correlated with progressive motility. Retinoic acid (RA) up-regulated level of sH3.3 in primary round spermatids and the C18-4 cells (a mouse spermatogonial stem cell line). Overexpression of the mutant H3.3 (Cysteine111 was replaced with serine) affected expression of 759 genes and raised growth rate of C18-4 cells. For the first time, S-sulfhydration H3 and H3.3 were demonstrated in the present study. Our results highlight that aberrant S-sulfhydration of H3 is a new pathophysiological basis in male infertility.

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The Role of Over-the-Counter Supplements in Male Infertility

Polackwich

Sabanegh

2015

Handbook of Fertility

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Importance of sperm gluthatione treatment in ART

Cited by 5 publications

References 22 publications

Medical Management of Male Infertility in the Absence of a Specific Etiology

Medical Management of Male Infertility in the Absence of a Specific Etiology

A novel posttranslational modification of histone, H3 S-sulfhydration, is down-regulated in asthenozoospermic sperm

The Role of Over-the-Counter Supplements in Male Infertility

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