Importance of the Spleen for the Immuno-Inhibitory Action of Linoleic Acid in Mice

Mertin, J.; Meade, Christopher J.; Hunt, Ruth; Sheena, Jinan

doi:10.1159/000231785

Cited by 34 publications

(8 citation statements)

References 15 publications

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“…The spleen is a major site for the production of immune-active PGs [16]. It was suspected that removal of this organ might influ ence the effectiveness of EFA treatment in suppres sing CMI responses and, indeed, EFA-induced sup pression of skin allograft rejection in mice and of EAE in rats was shown to be abolished by splenec tomy [17,18]. Further evidence supporting the postu lated EFA-PG relationship was obtained with admin istration of indomethacin, a drug which by blocking the cyclo-oxygenase enzyme system inhibits the con version of EFA into PG or thromboxane.…”

Section: Introductionmentioning

confidence: 99%

Nutrition and Immunity: The Immunoregulatory Effect of n-6 Essential Fatty Acids Is Mediated through Prostaglandin E

Mertin¹,

Stackpoole²,

Shumway³

1985

Int Arch Allergy Immunol

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Suppression of cell-mediated immune responses by essential fatty acids (EFA) was demonstrated in mice maintained on a standard laboratory diet for rodents. Daily oral administration of EFA at doses ranging from 125 to 750 mg/kg body weight significantly suppressed local host-versus-graft and graft-versus-host reactions as measured by popliteal lymph node assay. Studies employing immune sera directed against E-type prostaglandin demonstrated that n-6 EFA-induced suppression was mediated through prostaglandin E₁ In titration experiments the effect of n-6 EFA on the reactions was dose dependent with enhancement of the responses at low concentrations and suppression at high concentrations.

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Section: Introductionmentioning

confidence: 99%

Nutrition and Immunity: The Immunoregulatory Effect of n-6 Essential Fatty Acids Is Mediated through Prostaglandin E

Mertin¹,

Stackpoole²,

Shumway³

1985

Int Arch Allergy Immunol

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“…5,6 Consequently, the present study was undertaken to determine whether the apparent immunosuppressive prop¬ erties of polyunsaturated fats observed in experimental settings limit the clinical utility of fat emulsions when they are administered in combination with glucose, amino acids, vitamins, and trace elements. However, few data are available regarding the effect of lipid-based TPN sys¬ tems on cellular immunity.…”

Section: Resultsmentioning

confidence: 99%

Lipid-Based Parenteral Nutrition and the Immunosuppression of Protein Malnutrition

Wagner¹,

Silberman²

1984

Arch Surg

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“…So far it is not clear if the immunosuppressive effect of stress acts via an increase of the plasma FFA levels; however, the correlation between the quantity of certain types of fatty acids in the diet and an effect on the immune response and/or tumor induction has been established recently (6,11,15,17). Especially linoleic acid, a PUFA, seems to play an important role in a lot of immune processes.…”

Section: Discussionmentioning

confidence: 99%

Effect of Stress and Dietary Fatty Acids on Allograft Survival in the Rat

Kort¹,

Weijma²,

Westbroek³

1979

Eur Surg Res

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To determine the immunosuppressive effect of stress and a diet rich on linoleic acid on vascularized organ graft survival in the rat, a series of allogeneic heart and kidney grafts were carried out. Restraint stress resulted in a significant prolongation of the survival time. Although 5 days of postoperative stress gave the best results, 3 h of stress given on the first postoperative day already gave a marked prolongation of the survival time of kidney allografts. The beneficial effect of stress on heart survival was abolished when prior adrenalectomy was carried out. A diet high on polyunsaturated fatty acids gave significant prolongation of the survival times of kidney-grafted rats. A diet high on saturated fatty acids did not result in a statistical significant prolongation of the survival time, although the difference with the polyunsaturated fatty acid group was very small and not statistically significant. It was concluded that stress and diets high in certain types of fatty acids depress the immune response in rats, possibly via a mechanism which has some common pathways. The adrenal glands could play an important role in this immune inhibition.

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Importance of the Spleen for the Immuno-Inhibitory Action of Linoleic Acid in Mice

Cited by 34 publications

References 15 publications

Nutrition and Immunity: The Immunoregulatory Effect of n-6 Essential Fatty Acids Is Mediated through Prostaglandin E

Nutrition and Immunity: The Immunoregulatory Effect of n-6 Essential Fatty Acids Is Mediated through Prostaglandin E

Lipid-Based Parenteral Nutrition and the Immunosuppression of Protein Malnutrition

Effect of Stress and Dietary Fatty Acids on Allograft Survival in the Rat

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