Importance of tumor infiltrating lymphocytes in non-small cell lung cancer?

Bremnes, Roy M.; Dønnem, Tom; Busund, Lill-Tove

doi:10.21037/atm.2016.03.28

Cited by 7 publications

(4 citation statements)

References 22 publications

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“…We found sTIL appears to have a superior prognostic impact when compared with iTIL, which is previously reported in other tumours2122. In this study, we confirmed that sTIL constitutes a robust and independent prognostic marker in ESCC, with increasing sTIL predictive of a significantly lower risk of recurrence or metastasis, and overall mortality.…”

Section: Discussionsupporting

confidence: 88%

Tumour infiltrating lymphocytes correlate with improved survival in patients with esophageal squamous cell carcinoma

Jiang

Liu

Wang

et al. 2017

Sci Rep

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We undertook a study of tumour infiltrating lymphocytes (TILs) in a large and relatively homogeneous group of patients with completely resected esophageal squamous cell carcinoma (ESCC). Hematoxylin and eosin–stained sections of 235 ESCC tumours were evaluated for density of TILs in intratumoural (iTIL) and stromal compartments (sTIL). Foxp3+, CD4+, and CD8+ T cells in tumoural and stromal areas were evaluated by immunohistochemistry. Of the 235 tumours, high sTIL (>10%), and iTIL (>10%) were observed in 101 (43.0%) and 98 (41.7%), respectively. The median follow-up period was 36.0 months (95% CI 29.929–42.071). Univariate analysis revealed that sTIL (>10%), iTIL (>20%), vessels involvement, lymph node metastasis, and clinical stage were significantly associated with postoperative outcome. In multivariate analysis, high sTIL (HR: 0.664, P = 0.019 for Disease free survival; HR: 0.608, P = 0.005 for Overall survival) was identified as independent better prognostic factor. Further analysis, sTIL was identified as independently prognostic factor in Stage III-IVa disease, which was not found in Stage I-II disease. Our study demonstrated that sTIL was associated with better ESCC patients’ survival, especially in Stage III-IVa disease. Assessment of sTIL could be useful to discriminate biological behavior for ESCC patients.

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Section: Discussionsupporting

confidence: 88%

Tumour infiltrating lymphocytes correlate with improved survival in patients with esophageal squamous cell carcinoma

Jiang

Liu

Wang

et al. 2017

Sci Rep

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“…Most studies on lung cancer regarding tumor infiltrating ICs and PD-1/PD-L1 expression have been performed in NSCLC as a single cohort comprising at least both adenocarcinomas and squamous cell carcinomas. 14,30,[35][36][37][38] Moreover, studies on brain metastasis also included metastases pooled from various sites of origin, 16,17 so the well-known biological and therapeutic differences among the various histological subtypes may have a strong influence on the results. Therefore, in our present work we focused exclusively on brain metastasis cases from lung adenocarcinoma (LUAD) to create a more homogeneous cohort.…”

Section: Importance Of the Studymentioning

confidence: 99%

Evaluating the significance of density, localization, and PD-1/PD-L1 immunopositivity of mononuclear cells in the clinical course of lung adenocarcinoma patients with brain metastasis

et al. 2017

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This is the first study demonstrating the independent prognostic value of mononuclear rings in LUAD cases with brain metastasis. Our results also suggest that the density of tumor-associated ICs in addition to PD-L1 expression of tumor cells and ICs as well as PD-1 expression of ICs may hold relevant information for the appropriate selection of patients who might benefit from anti-PD-L1 or anti-PD-1 therapy.

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“…NSCLC histopathology is characterized by a complex interplay of tumor cells, immune cells (lymphocytes, plasma cells, macrophages, and granulocytes), fibroblasts, and pericytes/endothelial cells. Recent evidence suggests that the interaction of tumor cells with immune cells has a high association with likelihood of disease progression and influences tumor development, invasion, metastasis, and patient outcome (1,2). Several independent studies (2, 4-6) meanwhile have also shown an association between patient survival and treatment response with an increased density of tumor-infiltrating lymphocytes (TIL) in diverse solid tumor types.…”

Section: Introductionmentioning

confidence: 99%

Spatial Architecture and Arrangement of Tumor-Infiltrating Lymphocytes for Predicting Likelihood of Recurrence in Early-Stage Non–Small Cell Lung Cancer

Corredor

Wang

Zhou

et al. 2019

Clinical Cancer Research

202

169

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Importance of tumor infiltrating lymphocytes in non-small cell lung cancer?

Cited by 7 publications

References 22 publications

Tumour infiltrating lymphocytes correlate with improved survival in patients with esophageal squamous cell carcinoma

Tumour infiltrating lymphocytes correlate with improved survival in patients with esophageal squamous cell carcinoma

Evaluating the significance of density, localization, and PD-1/PD-L1 immunopositivity of mononuclear cells in the clinical course of lung adenocarcinoma patients with brain metastasis

Spatial Architecture and Arrangement of Tumor-Infiltrating Lymphocytes for Predicting Likelihood of Recurrence in Early-Stage Non–Small Cell Lung Cancer

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