Importance of tumour thickness measurement in prognosis of tongue cancer

Oral squamous cell carcinoma: Review of prognostic and predictive factors

“…Cancer staging is based on the TNM system, which has been labeled as imperfect, per se, for prognostic purposes. 8,9,12,13,[26][27][28][29][30] However, the vast majority of authors accepts that disease staging has a crucial influence on the outcome. Guerra et al 31 reported 5-year survival rates of 82% for initial stages and 49% for advanced disease.…”

“…Lo et al 7 described 5-year survival rates of 75%, 65.6%, 49%, and 30% for disease stages I, II, III, and IV, respectively. Gonzales-Moles et al 26 showed categorical influence of parameters T, pathologic T, N, and pathologic N on the vital prognosis. Nguyen and Yueh 9 found 1-year survival rates of 60% (stage I) and 32% (stage IV) in patients with recurrence, persistent disease, or second primary cancer.…”

“…The risk of nodal metastases and mortality rates vary directly with the thickness of the primary tumor. 8,11,26 O-charoenrat et al found that tumor thickness above 5 mm is a strong predictor of occult nodal metastases and should indicate an elective neck dissection. 8 There is evidence that tumor thickness may exercise more influence on the survival rates than factors such as clinical and pathologic staging.…”

“…8 There is evidence that tumor thickness may exercise more influence on the survival rates than factors such as clinical and pathologic staging. 26 Extracapsular spread (ECS). Defined as extranodal extension of metastatic deposits outside the lymph node capsule (Fig.…”

Impact of Clinical and Histo-Pathological Prognostic Factors on T1-2N0-1 Oral Tongue Carcinoma

“…Tumor thickness has been considered to correlate with cervical lymph node metastasis but there is no clear consensus of how to measure depth or thickness and also the decisive cut-off level for elective neck treatment. Measurement of tumor thickness by using the distance between the maximum depth of the tumor and the imaginary mucosal line by using optical micrometer as previously described in a study [17] which represent the aggressiveness of the tumor in vertical growth plane was used. From the statistic evaluation, the thickness of [7 mm is the cut point which significantly affected LR and interestingly, there was no correlation with RR.…”