Importance of viscoelasticity in the thixotropic behavior of human blood

Armstrong, Matthew; Rook, Katelyn; Pulles, Wes; Deegan, Michael; Corrigan, Trevor

doi:10.1007/s00397-020-01256-y

Cited by 7 publications

(9 citation statements)

References 57 publications

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“…A TA Instruments ARES-G2 strain-controlled rheometer with a double wall couette was utilized for all experimental measurements 3 , 5 , 8 . The specific dimensions and measurable range of the couette geometry are identical to those of previous work 44 , 46 , 47 . No later than 60 min from collection the blood samples were introduced to the rheometer for testing, with all analysis occurring within 4 h from withdrawal.…”

Section: Methodssupporting

confidence: 59%

“…Being counted among one of the most useful contemporary models the tensorial ethixo-mHAWB, an enhanced tensorial variant of the original mHAWB model, provides a basis of comparison against for the framework developed above 3 , 44 . The t-ethixo-mHAWB approach requires 13 parameters, 10 of which must be fitted via the procedure discussed in “ Methods ” section.…”

Section: Model Developmentmentioning

confidence: 99%

“…The separation of thixotropic response, viscoelastic response, shear structure breakage and structure build-up into separate timescales in models such as ethixo-mHAWB best allows the accurate replication of blood’s rheological behavior and the rouleaux within 3 , 44 . While this does add more parameters, contributing to model complexity, the new thixotropic and viscoelastic timescales provide vital insight into the evolution of the bloodstream’s rouleaux.…”

Section: Introductionmentioning

confidence: 99%

“…The improved mHAWB variant of the model would manifest through the incorporation of a rouleaux viscoelastic response into TVM 3 . The mHAWB model itself has seen several modifications and improvements, with new elements integrated to produce the ETV and ESSTV models 3 , 44 .…”

Section: Introductionmentioning

confidence: 99%

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Novel tensorial Thixo-Visco-Plastic framework for rheological characterization of human blood

Pincot

Armstrong

2021

Sci Rep

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Characterizing human blood, a complex material with a spectrum of thixo-elasto-visco-plastic properties, through the development of more effective and efficient models has achieved special interest of late. This effort details the development a new approach, the tensorial-enhanced-Thixo-Visco-Plastic model (t-e-TVP), which integrates elements from the proven Bingham and generalized Maxwell systems to create a more robust framework and subsequently cast into a tensorial format. Here, the elastic and viscoelastic stress contributions from the microstructure are superimposed upon the viscoelastic backbone solution for stress offered by the modified TVP frame. The utility of this novel model is tested against the contemporary tensorial-ethixo-mHAWB (t-ethixo-mHAWB) framework, a similar model with a greater number of parameters, using rheological data of human blood collected on an ARESG2 strain-controlled rheometer. The blood samples are parametrically and statistically analyzed, entailing the comparison of the t-e-TVP and t-ethixo-mHAWB models with their capacity to accurately predict small and large amplitude oscillatory shear as well as unidirectional large amplitude oscillatory shear flow in blood.

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Section: Methodssupporting

confidence: 59%

Section: Model Developmentmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Novel tensorial Thixo-Visco-Plastic framework for rheological characterization of human blood

Pincot

Armstrong

2021

Sci Rep

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“…Other variants, such as ethixo-mHAWB [10], have been presented with slight modifications to the kinetic equation to represent the structural parameter more accurately in the use of a shear aggregation term. A further modification, relevant to this work, manifested in the enhanced thixotropic viscoelastic (ETV) model [9,40].…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in Biofluid Mechanics and Bio- and Hemorheology Collating Recent Advances in Predicting Complex Behavior of Human Blood With Thixo-Elasto-Visco-Plastic Models and Sequence of Physical Process

et al. 2022

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For years industrial polymer production has driven the development of rheological models to characterize the flow of materials. With the evolution of these models has come a corresponding advancement in the understanding of the complex mechanical properties. Recent efforts have been focused on modeling the behavior of complex fluids such as blood, whose microstructure leads to has simultaneous characteristics such as: thixotropy; elasticity; plasticity; and an evolving viscosity (part of which originates with the rouleaux’s evolution). The specific complex behavior of human blood can be analyzed via the analysis of Large-Amplitude-Oscillatory-Shear (LAOS) and Small-Amplitude-Oscillatory-Shear (SAOS) response tests. Unique features of human blood cannot be replicated in legacy steady-state models and, thus, have required the development of more comprehensive models capable of accurately fitting both steady state, transient flow and oscillatory shear flow. Expanding upon prior transient models, collaboration between the Chemical Engineering departments of the United States Military Academy and the University of Delaware has produced a new model, tensorial enhanced structural stress thixotropic-viscoelastic model (t-ESSTV). This model can capture the timescales contained within the plasma and individual red blood cells viscoelasticity and the thixotropic timescales associated with rouleaux breakdown and aggregation. The efficacy of t-ESSTV is demonstrated with a single Donor before consolidating the best fit model parameters of twelve Donor sets of rheological data. We then show the parametric correlations between model and physiological parameters and with the models’ prediction of microstructure, we correlate microstructure with the “elastic, solid-like” metrics as computed by Sequence of Physical Processes (SPP).

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Non‐linear viscoelasticity of carbon black–fluoroether rubber mixture studied by large amplitude oscillatory shear tests

Song,

Yang,

Wang

et al. 2023

Polymer Engineering & Sci

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Non‐linear viscoelastic characteristics of carbon black (CB)‐filled fluoroether rubber mixture samples are investigated by large amplitude oscillatory shear (LAOS) tests. Three analysis approaches based on LAOS tests are then used to discuss correlations between rheological behavior and CB‐filling amount. Each non‐linear viscoelastic parameter of the mixture presents a three‐stage characteristic with increasing CB content, which are attributed to the alteration of CB–elastomer network structure, corresponding to the state where gum continuous phase, CB–elastomer mesophase, and excessive CB agglomerates predominate in the mixture compound, respectively. According to the findings in engineering experiments, a CB content of 35–40 phr is recommended, taking into account tensile, hardness, and aging properties. Excessive CB agglomerates are found to reinforce CB–elastomer networks at elevated temperatures. For cold‐resistance properties, structural changes in CB–elastomer network are proven to exert little effect on Tg, but a higher CB content was found to slightly enhance the cold‐resistance coefficient, probably due to the decrease in velocity fraction of gum rubber.Highlights LAOS tests were utilized to study the influences of CB on fluoroelastomer; Three‐stage alteration was observed in the mixture with increasing CB content; Correlation between CB content and the engineering properties was discussed.

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Importance of viscoelasticity in the thixotropic behavior of human blood

Cited by 7 publications

References 57 publications

Novel tensorial Thixo-Visco-Plastic framework for rheological characterization of human blood

Novel tensorial Thixo-Visco-Plastic framework for rheological characterization of human blood

Recent Advances in Biofluid Mechanics and Bio- and Hemorheology Collating Recent Advances in Predicting Complex Behavior of Human Blood With Thixo-Elasto-Visco-Plastic Models and Sequence of Physical Process

Non‐linear viscoelasticity of carbon black–fluoroether rubber mixture studied by large amplitude oscillatory shear tests

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