Importance of Zebrafish as an Efficient Research Model for the Screening of Novel Therapeutics in Neurological Disorders

Abstract

Abstract:: In the previous years of research, the use of animal model becomes very common for the screening of novel drugs. Animal model represents the complex problems of humans into simplest forms which can be extended further to include the experimental procedure. The most successful models in neuroscience, rats and mice, undoubtedly considered as one of the best models to understand the psychology of mammalian brain and its associated functions involved in various behavioral repertoire. Moreover, recently researchers in behavioral neuroscience are focusing more on the use of aquatic animals especially fish as model species due to their simplicity, and cost effectiveness. Zebrafish (Danio rerio) is a tropical fish from minnow family a genetic structure surprisingly 84 % similar to humans. It is gaining popularity as a model to study the mechanism in behavioral neuropharmacology. Moreover, Zebrafish is having numerous advantages over other rodent models like ease in maintenance due to their small size; breeding power is more, transparency of embryos, overall reduced cost of experimentation and many more. Nowadays, it is considered as an ideal model to study the neurobehavioral aspects with relevance to humans. It is also used in varieties of scientific studies like genetics, neuroscience, pharmacology, and toxicology. In this manuscript, we have described the feasibility and importance of Zebrafish as a model for the screening of novel drugs for different neurological disorders.

A Review on Role of Zebrafish in Huntington’s Disease

“…These examinations additionally explored the impact of collection inhibitors which recommended that the avoidance of accumulation didn't decrease the harmful impact on the fish, inferring that the development of more modest middle totals was the fundamental driver of poisonousness [14]. Hence, these models could be utilized to evaluate for novel mixtures for the treatment of HD by assessing either the anticipation of total development, improved freedom of totals, or the decrease in incipient organism demise [15][16][17][18][19][20]. The zebrafish CNS is comparatively organized to that of different vertebrates and is customarily isolated into the climbing, slipping spinal cord, cranial nerves, motor spinal string, hindbrain, midbrain, Forebrain and tactile nerves.…”

On the possibility of using highly sensitive SFCO sensors for studies in the field of behavioral physiology

“…Behavioral characteristics are an integral part of research on the effects of neuro-, myo-, and cardio tropic pharmacological agents at the stage of preclinical studies. Identi cation of behavioral changes under the in uence of pharmacological drugs provides insight into the mechanisms of their action, possible targets, and also allows one to assess the duration of effects and pharmacodynamics in general [32][33][34][35][36]. This circumstance dictates the need to develop systems for registration of locomo tor activity of laboratory animals with the possibility to process the data obtained and calculate spe ci c parameters -the speed of movement, the distance covered in a xed time, the number and du ration of stops (freezes), the duration of some speci c patterns of animal behavior, etc.…”

Zebrafish as a Potential Model for Neurodegenerative Diseases: A Focus on Toxic Metals Implications

“…The zebrafish is a tropical fish of the Cyprinidae family [ 5 ], with a genetic structure similar to humans of between 70 and 84% and can be used foremost to study human diseases [ 3 ]. It is a model animal that has acquired popularity in behavioural studies for various neural drugs [ 7 ]. It presents several advantages compared to other animal models, including ease of handling due to its small size, higher fecundity rate, embryo transparency, and low overall costs [ 8 , 9 ].…”

“…These organisms are used in different scientific studies, such as toxicology, pharmacology, neuroscience, and genetics [ 7 , 10 ]. Researchers frequently depend on zebrafish to evaluate the toxicity of various compounds.…”

“…Zebrafish were the basis for the diversity identification of genes that act negatively in distinctive aspects of neuronal development and function [ 5 ]. It is currently the essential model for studying neurobehavioral aspects relevant to humans [ 7 , 10 ]. The neurobehavioral function and life of model organisms are affected by numerous toxic substances whose impact is more accessible to evaluate in the laboratory than in their living environment.…”