Importance of zinc in the elderly: the ZENITH study

Meunier, N; O’Connor, Jacqueline M.; Maiani, Giuseppe; Cashman, Kevin D.; Secker, David L.; Ferry, M.; Roussel, Anne‐Marie; Coudray, Charles

doi:10.1038/sj.ejcn.1602286

Cited by 75 publications

(49 citation statements)

References 40 publications

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“…Our results suggest a correlation between Zn concentration and the age of patients, and indeed Zn deficiency is more frequent in the elderly [21]. According to a literature review, the role of Zn in carcinogenesis is not well understood [22].…”

Section: Discussionmentioning

confidence: 96%

Metals distribution in colorectal biopsies: New insight on the elemental fingerprint of tumour tissue

Rinaldi

Barabino

Klein

et al. 2015

Digestive and Liver Disease

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Section: Discussionmentioning

confidence: 96%

Metals distribution in colorectal biopsies: New insight on the elemental fingerprint of tumour tissue

Rinaldi

Barabino

Klein

et al. 2015

Digestive and Liver Disease

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“…It has a structural and functional role in a large number of macromolecules and is required for over 300 enzymic reactions. Zinc ions (Zn 2+ ) participate in all aspects of intermediary metabolism, transmission, and regulation of the expression of genetic information, storage, synthesis, and action of peptide hormones and structural maintenance of chromatin and biomembranes [51]. It is estimated that up to 1% of the human genome codes for zinc finger proteins.…”

Section: Micronutrient Contentmentioning

confidence: 99%

Nutritional and Anti-Nutrient Composition of Three Kola Nuts (<i> Cola nitida, Cola acuminata </i> and <i> Garcinia kola </i>) Produced in Benin

Dah-Nouvlessounon¹,

Adjanohoun²,

Sina³

et al. 2015

FNS

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Kola nuts were regularly chewed by West Africans and Beninese in particularly. The aim of this study was to investigate nutritional and anti-nutrient content of three Benin's kola nuts (Cola nitida, Cola acuminata and Garcinia kola). Proximate composition of the three species of kola nuts was assessed using standard analytical AOAC methods. Phenolics and flavonoids contents were determined by Folin-Ciocalteu and aluminum trichloride methods, respectively. Mineral composition was determined by Atomic Absorption Spectrometry method. Free and total amino acids were separated and quantified by HPLC. Protein content of the three kola nuts ranges from 4.95% (G. kola) to 10.64% (C. acuminata) whereas fat content ranges from 0.2 ± 0.00 (C. nitida) to 2.5 ± 0.42 (G. kola). Total phenolics abounded (2444.96 ± 81.56 µg Eq AG/100g) in C. acuminata, while flavonoids predominated (561.69 ± 22.10 µgEqQ/100g) in G. kola. The three species are a good source of magnesium and a copper provider was lowest in C. nitida (0.59 ± 0.08 mg/g) and in C. acuminata (0.65 ± 0.02 mg/g). The dominant total essential amino acids were threonine (C. acu-* Corresponding author. D. Dah-Nouvlessounon et al.1396 minata) and methionine (C. acuminata and G. kola), while the predominant non-essential total amino acids according to species were arginine (C. nitida and G. kola), proline (C. acuminata) and cysteine (G. kola). For the anti-nutrients factors, saponins were in great proportion (8.33% ± 0.25%), while the oxalates were in small proportion (0.44% ± 0.04%). The three species have an interesting nutritional composition, but these seeds have the relatively lowest amino acids content.

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“…At the molecular level, Zn is an exceptionally important micronutrient, required for over 300 enzymatic reactions that take place in the body (79), and is part of more than 2000 Zn dependent transcription factors and other proteins (80). Zinc is present in the cell nucleus, nucleolus, and the chromosomes.…”

Section: Ilmentioning

confidence: 99%

Insulino-mimetic and anti-diabetic effects of zinc

Vardatsikos

Pandey

Srivastava

2013

Journal of Inorganic Biochemistry

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blocked Zn-induced ERKl/2 and PKB phosphorylation, but AG1478, an inhibitor for EGFR was without effect. In CHO cells overexpressing tyrosine kinase deficient IR (CHO-1018), Zn was still able to induce the phosphorylation ERK1/2 and PKB/Akt, whereas insulin-induced ERK1/2 and PKB/Akt phosphorylation was abolished in these cells.Moreover, Zn had no effect on the tyrosine phosphorylation of IR-p-subunit and IRS-l in CHO-IR cells. Furthermore, in IGF-IR knockout cells, both IGF-l and Zn were unable to stimulate the phosphorylation ofERK1/2 and PKB. Taken together, these data suggest that Zn-induced ERK1/2 and PKB/Akt phosphorylation is independent of IR-or EGFR-PTK, but requires IGF-IR-PTK.

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Importance of zinc in the elderly: the ZENITH study

Cited by 75 publications

References 40 publications

Metals distribution in colorectal biopsies: New insight on the elemental fingerprint of tumour tissue

Metals distribution in colorectal biopsies: New insight on the elemental fingerprint of tumour tissue

Nutritional and Anti-Nutrient Composition of Three Kola Nuts (<i> Cola nitida, Cola acuminata </i> and <i> Garcinia kola </i>) Produced in Benin

Insulino-mimetic and anti-diabetic effects of zinc

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Importance of zinc in the elderly: the ZENITH study

Cited by 75 publications

References 40 publications

Metals distribution in colorectal biopsies: New insight on the elemental fingerprint of tumour tissue

Metals distribution in colorectal biopsies: New insight on the elemental fingerprint of tumour tissue

Nutritional and Anti-Nutrient Composition of Three Kola Nuts (&lt;i&gt; Cola nitida, Cola acuminata &lt;/i&gt; and &lt;i&gt; Garcinia kola &lt;/i&gt;) Produced in Benin

Insulino-mimetic and anti-diabetic effects of zinc

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Resources

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Nutritional and Anti-Nutrient Composition of Three Kola Nuts (<i> Cola nitida, Cola acuminata </i> and <i> Garcinia kola </i>) Produced in Benin