Importancia de la electrofisiología ocular en el diagnóstico de las distrofias retinianas

Domínguez-Serrano, F.B.; Jiménez-López, E.; Jiménez, Manuel; Ponte-Zuñiga, Beatriz; Gómez-Escobar, A.; Díaz-Granda, M.J.; Gutiérrez-Sánchez, Estanislao; Morillo-Sánchez, María José; Menéndez-de-León, C.; Rodríguez-de-la-Rúa-Franch, Enrique

doi:10.1016/j.oftal.2018.12.009

Cited by 3 publications

(1 citation statement)

References 3 publications

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“…With rapidly developing optical imaging technologies, the precise retinal structure is accessible and revolutionizes the assessment of patients with retinal disorders [ 8 , 9 ]. Regardless, the diagnostic value from physiological assessment of the retina renders ffERG indispensable for diagnosing retinal dysfunction [ 17 , 18 , 19 , 20 , 21 ]. In the present study, we demonstrated the consistency and importance of ffERG in ophthalmological practice ( Figure 1 B).…”

Section: Discussionmentioning

confidence: 99%

The Clinical Contribution of Full-Field Electroretinography and 8-Year Experiences of Application in a Tertiary Medical Center

Yang

Huang

Yang

et al. 2021

JPM

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Electroretinography (ERG) is an important and well-established examination for retinal and visual pathway diseases. This study reviewed the medical records of patients who received full-field ERG (ffERG) at a single medical center between 2012 and 2019, which was an 8-year experience in the clinical contribution of ERG. Based on the indication for scheduling ffERG and the final diagnosis, patients could be classified into six groups: ‘retinal dystrophies’, ‘other retinal or macular diseases’, ‘optic neuropathies’, ‘visual complaints’, ‘systemic diseases’, and ‘others’. A total of 1921 full-field electroretinograms (ffERGs) (1655 patients) were included. The average number of ffERGs performed per year was 262 and the number of annual ffERGs was constant. The ‘retinal dystrophies’ group accounted for 36.5% of the studied population, followed by the ‘other retinal or macular diseases’ group (20.2%). The most common systemic disease was central nervous system disease. The rates of abnormal ffERGs in the ‘systemic diseases’, ‘optic neuropathies’, and ‘visual complaints’ groups were 27.3%, 22.6%, and 10.1%, respectively (p < 0.001). Higher rates were found in patients <20 years old in the ‘systemic diseases’ and ‘optic neuropathies’ groups; epilepsy and optic nerve atrophy were the most common diagnoses, respectively. In brief, by quantifying the functional response in the retina, ffERG is indispensable for diagnosis and prognosis in ophthalmologic and multidisciplinary practice.

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Section: Discussionmentioning

confidence: 99%

The Clinical Contribution of Full-Field Electroretinography and 8-Year Experiences of Application in a Tertiary Medical Center

Yang

Huang

Yang

et al. 2021

JPM

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Multidisciplinary approach to inherited causes of dual sensory impairment

Arias-Peso,

Calero-Ramos,

López-Ladrón García de la Borbolla

et al. 2023

Graefes Arch Clin Exp Ophthalmol

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Assessing Residual Cone Function in Retinitis Pigmentosa Patients

Arsiwalla

Cornish

Nguyen

et al. 2020

Trans. Vis. Sci. Tech.

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Purpose The purpose of this study was to investigate cone function deterioration in patients with retinitis pigmentosa (RP) using full field electroretinogram (ffERG), pattern electroretinogram (pERG), and optical coherence tomography (OCT) and their correlation with visual acuity (VA). Methods Clinical records (2008–2018) of patients with RP undergoing repeat electrophysiology were reviewed. Results of ffERG (30 Hz flicker and fused flicker amplitude [FFAmp]), pERG [p50 and n95], and macular OCT (ellipsoid zone [EZ] and outer segment thickness) were collected. Results One hundred twenty-six eyes from 63 patients (33 women, mean age 35 years) were included. The mean decline in VA was 0.11 ± 0.14 logarithm of minimum angle of resolution (logMAR). The FFAmp decreased by 3.01 ± 5.9 µV with global cone function deteriorating by 18.7% annually. The percentage change in FFAmp (RE [ r = 0.553], LE [ r = 0.531]), and 30 Hz flicker amplitude (RE [ r = 0.615], LE [ r = 0.529]) strongly correlated with VA ( P < 0.00001). The pERG p50 (15 and 30 degrees) change analyzed in 34 patients showed reduction by 23% and 23.4%, respectively. The percentage change in p50 30 degrees ( r = 0.397) correlated with VA and EZ layer ( P < 0.05). The EZ layer change was calculated in 45 patients and the shortening and thinning rate was 4.3% and 4.4% annually, respectively. The EZ length percentage change correlated with VA (RE [ r = 0.34] and LE [ r = 0.466; P < 0.05). Conclusions We quantified the decline in cone function in patients with RP utilizing ffERG and FFAmp measures of residual cone function. These parameters correlated with VA and OCT when measurable. These objective measures may assist in monitoring disease progression. Translational Relevance Residual cone function provides an objective estimate of residual visual function, which aids in counselling patients regarding prognosis.

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Importancia de la electrofisiología ocular en el diagnóstico de las distrofias retinianas

Cited by 3 publications

References 3 publications

The Clinical Contribution of Full-Field Electroretinography and 8-Year Experiences of Application in a Tertiary Medical Center

The Clinical Contribution of Full-Field Electroretinography and 8-Year Experiences of Application in a Tertiary Medical Center

Multidisciplinary approach to inherited causes of dual sensory impairment

Assessing Residual Cone Function in Retinitis Pigmentosa Patients

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