Important Clinical Syndromes Associated with Liver Disease

Rothuizen, J.

doi:10.1016/j.cvsm.2009.02.007

Cited by 39 publications

(51 citation statements)

References 42 publications

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“…The complications associated with CH in dogs are listed in Supporting Information Table S5 and include PH, ascites, HE, coagulation disorders, infection, and gastroduodenal ulceration . Additional complications reported in humans with CH include hepatopulmonary syndrome, hepatorenal syndrome, spontaneous bacterial peritonitis, and hypersplenism.…”

Section: Complicationsmentioning

confidence: 99%

ACVIM consensus statement on the diagnosis and treatment of chronic hepatitis in dogs

Webster

Cullen

Penninck

et al. 2019

Veterinary Internal Medicne

198

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This consensus statement on chronic hepatitis (CH) in dogs is based on the expert opinion of 7 specialists with extensive experience in diagnosing, treating, and conducting clinical research in hepatology in dogs. It was generated from expert opinion and information gathered from searching of PubMed for manuscripts on CH, the Veterinary Information Network for abstracts and conference proceeding from annual meetings of the American College of Veterinary Medicine and the European College of Veterinary Medicine, and selected manuscripts from the human literature on CH. The panel recognizes that the diagnosis and treatment of CH in the dog is a complex process that requires integration of clinical presentation with clinical pathology, diagnostic imaging, and hepatic biopsy. Essential to this process is an index of suspicion for CH, knowledge of how to best collect tissue samples, access to a pathologist with experience in assessing hepatic histopathology, knowledge of reasonable medical interventions, and a strategy for monitoring treatment response and complications.

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Section: Complicationsmentioning

confidence: 99%

ACVIM consensus statement on the diagnosis and treatment of chronic hepatitis in dogs

Webster

Cullen

Penninck

et al. 2019

Veterinary Internal Medicne

198

View full text Add to dashboard Cite

show abstract

“…These clinical signs are usually divided into four stages (Table 1) (Munoz 2008, Rothuizen 2009, Salgado and Cortes 2013b) and the patient was classified as a Stage 2. Signs of HE are often waxing and waning and patients can then fluctuate between Stages I through IV episodically.…”

Section: Discussionmentioning

confidence: 99%

Acute onset of blindness secondary to a splenosystemic shunt in an adult cat

Bennaim

Pivetta

Beltrán

2014

Vet Record Case Reports

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An eight-year-old female, spayed, domestic, shorthair cat was presented for acute onset of blindness, lethargy, dysorexia and weight loss. On the basis of clinical presentation, clinicopathological findings, liver function tests and diagnostic imaging, a diagnosis of hepatic encephalopathy secondary to the presence of a hepatic vascular anomaly was made. The patient responded successfully to medical treatment. This case raises the importance of considering a portosystemic shunt as a possible cause of acute onset of neurological signs in adult cats. Additionally, it suggests a potential good response to medical treatment for splenosystemic shunts.

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“…A bile acid stimulation test, which is a well established and widely used assay to assess for the presence of portosystemic shunting in dogs, was also performed at the same time points (Center et al 1991). At time of sampling, the grade of HE (i.e., graded 0-4) was recorded based on a previously described system (Rothuizen 2009). The whole blood EDTA samples were frozen at -70 o C before being transported on dry ice as a batch to the Scottish Trace Element and Micronutrient Reference Laboratory.…”

Section: Methodsmentioning

confidence: 99%

Surgical attenuation of spontaneous congenital portosystemic shunts in dogs resolves hepatic encephalopathy but not hypermanganesemia

Gow

Frowde²,

Elwood³

et al. 2015

Metab Brain Dis

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Hypermanganesemia is commonly recognized in human patients with hepatic insufficiency and portosystemic shunting. Since manganese is neurotoxic, increases in brain manganese concentrations have been implicated in the development of hepatic encephalopathy although a direct causative role has yet to be demonstrated. Evaluate manganese concentrations in dogs with a naturally occurring congenital shunt before and after attenuation as well as longitudinally following the changes in hepatic encephalopathy grade. Our study demonstrated that attenuation of the shunt resolved encephalopathy, significantly reduced postprandial bile acids, yet a hypermanganasemic state persisted. This study demonstrates that resolution of hepatic encephalopathy can occur without the correction of hypermanganesemia, indicating that increased manganese concentrations alone do not play a causative role in encephalopathy. Our study further demonstrates the value of the canine congenital portosystemic shunt as a naturally occurring spontaneous model of human hepatic encephalopathy.

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Important Clinical Syndromes Associated with Liver Disease

Cited by 39 publications

References 42 publications

ACVIM consensus statement on the diagnosis and treatment of chronic hepatitis in dogs

ACVIM consensus statement on the diagnosis and treatment of chronic hepatitis in dogs

Acute onset of blindness secondary to a splenosystemic shunt in an adult cat

Surgical attenuation of spontaneous congenital portosystemic shunts in dogs resolves hepatic encephalopathy but not hypermanganesemia

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