Important details to be clarified about the effect of rectal ozone on the portal vein oxygenation

Bocci, Velio; Zanardi, Iacopo; Travagli, Valter

doi:10.1111/j.1365-2125.2011.03974.x

Cited by 2 publications

(3 citation statements)

References 3 publications

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“…In 1936, when Aubourg proposed the procedure, [31] it appeared a reasonable application for treating chronic colitis and fistulae. Nowadays, it has been proposed to ‘treat’ many other diseases [32–40] . The insufflation of a volume of 200–250 ml of gas into the rectum/colon at an O 3 concentration ranging from 5 to no more than 35 µg/ml can be precisely done, but the effective O 3 dose is unpredictable because of possible flatulence and the presence of a more or less abundant luminal content.…”

Section: Reliable and Doubtful Methods Of Ozone Administrationmentioning

confidence: 99%

“…Nowadays, it has been proposed to 'treat' many other diseases. [32][33][34][35][36][37][38][39][40] The insufflation of a volume of 200-250 ml of gas into the rectum/colon at an O3 concentration ranging from 5 to no more than 35 mg/ml can be precisely done, but the effective O3 dose is unpredictable because of possible flatulence and the presence of a more or less abundant luminal content. Thus, it is clear that a significant fraction of the dose will be neutralized by faecal material.…”

Section: Ozone Rectal Insufflationmentioning

confidence: 99%

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Reliable and effective oxygen-ozone therapy at a crossroads with ozonated saline infusion and ozone rectal insufflation

Bocci

Zanardi

Borrelli

et al. 2012

Journal of Pharmacy and Pharmacology

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Objectives This review aims to highlight the advantages and safety of oxygen-ozone therapy (OOT) and to suggest ways to enhance its acceptance. Key findings The treatment of a herniated disk by injecting a gaseous oxygen-ozone mixture inside the nucleus pulposus is a great clinical success. However, the use of OOT lags for a number of reasons, including lack of standardization, the need for numerous treatments, lack of knowledge and even denial. Anecdotally, several million treatments by OOT have been performed worldwide indicating its usefulness, mainly in peripheral arterial diseases and age-related macular degeneration. The scepticism that accompanies the systemic use of ozone can only be overcome by demonstrating the validity of OOT in controlled and randomized clinical trials. Cheaper and quicker methods, such as ozonating physiological saline with successive infusion as well as ozone rectal insufflations, are becoming popular, however, such alternative procedures are erratic, unstable and liable to be toxic, with deleterious consequences, and are likely to discredit the beneficial use of ozone. Summary The approval of ozone in terms of both therapeutic efficacy and safety will depend on the results achieved by authoritative clinical trials.

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Section: Reliable and Doubtful Methods Of Ozone Administrationmentioning

confidence: 99%

Section: Ozone Rectal Insufflationmentioning

confidence: 99%

Reliable and effective oxygen-ozone therapy at a crossroads with ozonated saline infusion and ozone rectal insufflation

Bocci

Zanardi

Borrelli

et al. 2012

Journal of Pharmacy and Pharmacology

Self Cite

View full text Add to dashboard Cite

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“…Hyperoxia O 3 -induced, counteracting the HIF1A factor, should increase the chemotherapy effect, by reducing the cancer cell resistance; furthermore, the hemorheological effects should facilitate the chemotherapy arrival at the level of hypoxic tumor nucleus; these two actions would lead to a reduction of effective chemotherapy's doses, and to a consequent reduction of its toxicity and side effects. Indirectly, it counteracts many adverse chemotherapy effects, for example, it is effective against dilated cardiomyopathy induced by doxorubicin (87), reduces the rate of infections increasing the immune system, increases the hemoglobin concentration with reduced sense of fatigue, reduces the incidence nausea and vomiting caused by the chemotherapy.…”

Section: Pharmacological Action Of Oxygen-ozone Mixturementioning

confidence: 99%

Possible Therapeutic Effects of Ozone Mixture on Hypoxia in Tumor Development

Luongo¹,

Brigida²,

Mascolo³

et al. 2017

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Recent literature highlights that ozone therapy could be considered a viable adjuvant therapy in oncological patients receiving radio-chemotherapy. The use of ozone therapy in these patients enhances the action of chemotherapy and at the same time reduces side-effects, such as nausea, vomiting, opportunistic infections, buccal ulcers, hair loss and fatigue. Such positive therapeutic effects of ozone therapy can cause a larger physical and mental wellbeing resulting in improved quality of life. This work reviews the recent acquisition of scientific knowledge regarding the ozone therapy and highlights the molecular and cellular pathways involved.

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Important details to be clarified about the effect of rectal ozone on the portal vein oxygenation

Cited by 2 publications

References 3 publications

Reliable and effective oxygen-ozone therapy at a crossroads with ozonated saline infusion and ozone rectal insufflation

Reliable and effective oxygen-ozone therapy at a crossroads with ozonated saline infusion and ozone rectal insufflation

Possible Therapeutic Effects of Ozone Mixture on Hypoxia in Tumor Development

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