Background Previous studies analyzing femoral components of TKAs have demonstrated the limited ability of these components to accommodate size variations seen in the patient population, particularly width and femoral offset. Questions/purposes The purpose of this study was to use a large data set of knee CT scans (1) to determine the variations in the distal and posterior femoral geometries and to determine whether there is a correlation between distal condylar offset and posterior femoral offset as a potential parameter for symmetry/asymmetry; and (2) to evaluate what proportion of knees would have a substantial mismatch between the implant's size or shape and the patient's anatomy if a femoral component of a modern standard TKA of symmetric (sTKA) or asymmetric (asTKA) designs were to be used. One of the authors (SZ) is an employee of Conformis Inc (Billerica, MA, USA). One of the authors certifies that he (AS) has received personal fees for consultant teaching, during the study period, in an amount of less than USD 10,000 from Conformis Inc, outside the submitted manuscript. One of the authors certifies that he (WK) has received or may receive research support and royalties, during the study period, in an amount of USD 10,000 to USD 100,000 from Conformis Inc, outside the submitted manuscript. One of the authors certifies that he (FK) has received personal fees and grants, during the study period, in an amount of less than USD 10,000 from Conformis Inc, outside the submitted manuscript. One of the authors certifies that he (JB) has received personal fees for consultant teaching, during the study period, in an amount of less than USD 10,000, from Smith & Nephew (Smith & Nephew GmbH, Hamburg, Germany) and personal fees for consultant teaching in an amount of less than USD 10,000 from Conformis Inc, all outside the submitted manuscript. Clinical Orthopaedics and Related Research® neither advocates nor endorses the use of any treatment, drug, or device. Readers are encouraged to always seek additional information, including FDA approval status, of any drug or device before clinical use. Each author certifies that his or her institution waived approval for the reporting of this investigation and that all investigations were conducted in conformity with ethical principles of research.