Important role of muscle carnosine in rowing performance

Baguet, Audrey; Bourgois, Jan; Vanhee, Lander; Achten, Eric; Derave, Wim

doi:10.1152/japplphysiol.00141.2010

Cited by 144 publications

(190 citation statements)

References 36 publications

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“…Much of the positive effect was explained by significant improvements (p = 0.013) in exercise capacity, although BA did not significantly improve exercise performance (p = 0.204). However, it should be noted that few studies have addressed the effect of BA on sports-specific tasks, and the findings of those that have are conflicting (Derave et al 2007;Van Thienen et al 2009;Baguet et al 2010;Bellinger et al 2012;Saunders et al 2012).…”

Section: Introductionmentioning

confidence: 99%

The ergogenic effect of beta-alanine combined with sodium bicarbonate on high-intensity swimming performance

Painelli

Roschel

Jesus

et al. 2013

Appl. Physiol. Nutr. Metab.

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We investigated the effect of beta-alanine (BA) alone (study A) and in combination with sodium bicarbonate (SB) (study B) on 100- and 200-m swimming performance. In study A, 16 swimmers were assigned to receive either BA (3.2 g·day−1 for 1 week and 6.4 g·day−1 for 4 weeks) or placebo (PL; dextrose). At baseline and after 5 weeks of supplementation, 100- and 200-m races were completed. In study B, 14 were assigned to receive either BA (3.2 g·day−1 for 1 week and 6.4 g·day−1 for 3 weeks) or PL. Time trials were performed once before and twice after supplementation (with PL and SB), in a crossover fashion, providing 4 conditions: PL-PL, PL-SB, BA-PL, and BA-SB. In study A, BA supplementation improved 100- and 200-m time-trial performance by 2.1% (p = 0.029) and 2.0% (p = 0.0008), respectively. In study B, 200-m time-trial performance improved in all conditions, compared with presupplementation, except the PL-PL condition (PL-SB, +2.3%; BA-PL, +1.5%; BA-SB, +2.13% (p < 0.05)). BA-SB was not different from BA-PL (p = 0.21), but the probability of a positive effect was 78.5%. In the 100-m time-trial, only a within-group effect for SB was observed in the PL-SB (p = 0.022) and BA-SB (p = 0.051) conditions. However, 6 of 7 athletes swam faster after BA supplementation. The probability of BA having a positive effect was 65.2%; when SB was added to BA, the probability was 71.8%. BA and SB supplementation improved 100- and 200-m swimming performance. The coingestion of BA and SB induced a further nonsignificant improvement in performance.

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Section: Introductionmentioning

confidence: 99%

The ergogenic effect of beta-alanine combined with sodium bicarbonate on high-intensity swimming performance

Painelli

Roschel

Jesus

et al. 2013

Appl. Physiol. Nutr. Metab.

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“…These results are consistent with previous research using trained participants [52,100,116,132]. The authors suggest that the wrestlers in the study may have been restricting their carbohydrate intake in order to make weight for an upcoming competition and every wrestler (in both groups)…”

Section: S)supporting

confidence: 91%

“…Stellingwerf et al [98] hypothesised that individuals with low baseline carnosine levels such as vegetarians, females or the elderly [58], might respond to a greater extent to β-alanine supplementation than those having higher resting concentrations. However, contrary to this hypothesis Baguet et al [100] found a positive correlation between high baseline levels and the increase in M-Carn in eight elite rowers. In addition, no relationship between baseline carnosine levels and increases in M-Carn was found in 21 young males [101].…”

Section: β-Alanine Supplementationmentioning

confidence: 76%

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β–alanine: performance effects, usage and side effects

Kelly¹

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β-alanine is a relatively new ergogenic aid and a number of questions relating to its effectiveness in enhancing high intensity exercise performance remain to be addressed. The five studies described in this thesis examined the influence of β-alanine supplementation and high intensity training on exercise capacity and considered factors that potentially influence dosage compliance and side effects -factors that may impact on the ergogenic value of β-alanine supplementation. Study 1 examined the efficacy of β-alanine supplementation in conjunction with repeated sprint and sprint interval training (and combined with a pre-exercise dose of sodium bicarbonate), on repeated-sprint ability and high intensity cycling capacity (time to fatigue at 110% of maximum power output). β-alanine supplementation, when combined with sprint and interval training, improved repeated sprint ability but did not influence high intensity cycle capacity. Furthermore, acute sodium bicarbonate ingestion improved high intensity cycle capacity before training but had no influence on either repeated sprint ability or exercise capacity after training. It is likely that intramuscular buffer capacity increased as a result of training and that this may have outweighed the potential ergogenic buffering effects of β-alanine and sodium bicarbonate (i.e., both alone and in combination).Study 2 investigated β-alanine supplementation use and level of knowledge amongst professional rugby union (n = 87), rugby league (n = 180) and Australian Rules Football (n = 303) players. Over half the professional footballers surveyed used β-alanine, yet most supplemented in a manner inconsistent with recommendations. A better understanding of the environment and culture within professional football codes is required before supplement use aligns with evidence-based β-alanine supplementation recommendations. In light of these findings, Study 3 examined compliance levels to β-alanine supplementation in an applied setting. Compliance over a 28 day period was 59% (± 24%) which was significantly lower than the mean compliance rate reported by others (96%) (p < 0.0001). It was concluded that the determinants of β-alanine (non-) compliance in athletes needed to be further investigated. Study 4 examined potential relationships between different β-alanine dosages and side effects. Healthy male participants were divided into low (< 75 kg) and high (> 85kg) body mass groups and completed three supplementation treatments: 1. a placebo, 2. β-alanine as a relative dose of 0.02 g·kgBM -1 and 3. β-alanine as an absolute dose of 1.6 g. For 90 min following supplementation in each condition, participants completed a questionnaire that sought responses to side effects. It was found that lighter individuals iii experienced fewer side effects when they supplemented with β-alanine as a dose relative to body mass; heavier individuals experienced fewer side effects when they consumed an absolute dose of 1.6 g. It was concluded that individualising the supplementation of β-alanine is...

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“…Although carnosine is not involved in the classic ATP-generating metabolic pathways, this suggests an important role of the dipeptide in the homeostasis of contracting muscle cells, especially during high rates of anaerobic energy delivery. Carnosine can offset acidosis by acting as a pH buffer, but improved contractile performance may also be obtained by enhanced excitation-contraction coupling and defence against reactive oxygen species [26][27][28][29][30][31]. Betaalanine is rapidly rising as a popular ergogenic nutritional increment for athletes worldwide, and the currently accessible scientific prose proposes that its practice is evidence-based.…”

Section: Carnosinementioning

confidence: 99%

?-Amino Acids: Role in Human Biology and Medicinal Chemistry - A Review

Riaz¹,

Fazal-ur-Rehman²,

Ahmad³

2017

Med chem

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Abstractβ-amino acids are an important class of macromolecules. They play role in life for survival. β-amino acids gained significant interest due to their interesting pharmaceutical uses as hypoglycemic, antiketogenic characteristics, sterile and antifungal activities, anthelminthic as well as potent insecticidal characteristics. These are vital building blocks for the preparation of pharmaceutical and agrochemical target molecules. These are utilized in development of drugs, bimolecular structure and molecular recognition. They are also important in treatment of different diseases which are viral to human health. They play important role in regulation of nutritional metabolism and immunity. It has also led to their wider adoption as intermediates in new drugs and has been a focus of considerable attention in medicinal chemistry. β-amino acids have found extensive applications as components of biologically active peptides and small molecule pharmaceuticals. Synthetic derivatives of biologically relevant peptides incorporating β-amino acids often display interesting pharmacological activity, with increased potency and enzymatic stability. β-peptides participate in arrangement of incredible stable auxiliary structures. This review summarizes recent developments about the different roles of β-amino acids in human biology and some implications in medicinal chemistry.

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Important role of muscle carnosine in rowing performance

Cited by 144 publications

References 36 publications

The ergogenic effect of beta-alanine combined with sodium bicarbonate on high-intensity swimming performance

The ergogenic effect of beta-alanine combined with sodium bicarbonate on high-intensity swimming performance

β–alanine: performance effects, usage and side effects

?-Amino Acids: Role in Human Biology and Medicinal Chemistry - A Review

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