Imported Human Trichinellosis: Sequential IgG4 Antibody Response to Trichinella spiralis

Pinelli, Elena; Mommers, M.; Homan, Wieger; Maanen, T. van; Kortbeek, L. M.

doi:10.1007/s10096-003-1039-7

Cited by 13 publications

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References 10 publications

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“…spiralis includes adult worms, newborn larvae, and muscle larvae (ML) [ 1 , 11 ]. The encapsulation of ML in the skeletal muscles may cause acute phase symptoms such as fever, myalgia, and eosinophilia [ 12 ]. During its intimate interaction with the host, Trichinella adopts itself to modulate the host immune function for its survival.…”

Section: Introductionmentioning

confidence: 99%

Proteomic analysis of the response of Trichinella spiralis muscle larvae to exogenous nitric oxide

et al. 2018

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Trichinella spiralis mainly dwells in the muscle tissue of its host and is the main causative agent of trichinellosis in humans. Nitric oxide (NO), an important intracellular signaling molecule that may restrict pathogen growth in infected hosts, has been known for its anti-pathogenic activity, including resistance to T. spiralis. Herein, we applied label-free analysis to investigate the effect of sodium nitroprusside (SNP, a NO donor compound) on the proteome of T. spiralis muscle larvae (ML), followed by Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway cluster analyses. Of the 1,476 proteins detected in the ML, 121 proteins showed differential expression, including 50 significantly upregulated and 71 downregulated proteins. The functions of the 108 annotated proteins were primarily related to signal transduction, transcription/translation, material metabolism, protein synthesis/assembly/degradation, and stress/defense/antioxidation. Quantitative real-time polymerase chain reaction (qRT-PCR) assay verified that FRMD5 and CUT-1 gene expression levels were significantly increased, while COX2 gene expression level was significantly decreased. GO annotation and KEGG pathway analyses showed that the majority of differentially expressed proteins were mainly involved in the molecular function of the catalytic activity, biological process of the immune system process, metabolic process, cellular component organization, biological adhesion, and cellular component of the macromolecular complex. Our results demonstrate the first comprehensive protein expression profile of the ML in response to NO stress and provide novel references for understanding the potential mechanism underlying the effects of NO on trichinellosis.

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Section: Introductionmentioning

confidence: 99%

Proteomic analysis of the response of Trichinella spiralis muscle larvae to exogenous nitric oxide

et al. 2018

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Trichinellosis

Bruschi

Dupouy‐Camet

2022

Helminth Infections and Their Impact on Global Public Health

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Trichinellosis

Bruschi¹,

Dupouy‐Camet²

2014

Helminth Infections and Their Impact on Global Public Health

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Trichinellosis is a worldwide zoonosis caused by the parasitic nematodes\ud belonging to the Trichinella genus.\ud This chapter describes the different aspects of epidemiology of infection, the life\ud cycle of the parasite and the host immune response to the different species of\ud Trichinella in humans, as well as in rodents which represent the most studied\ud experimental model. The roles of antibodies, T cells, mast cells, eosinophils and\ud neutrophils in immune responses to this nematode are considered in experimental\ud as well as in human infections. Immunopathological aspects of infection are also\ud illustrated.\ud Particular emphasis is given on the clinical diagnosis of trichinellosis which is\ud difficult because of the lack of pathognomonic signs or symptoms. Therefore,\ud anamnestic data are of great importance in diagnosing the infection. High eosinophilia\ud and increased creatine phosphokinase (CPK) activity in the serum are the\ud most frequently observed laboratory features, but only the finding of parasites in a\ud muscle biopsy and the detection of specific circulating antibodies can confirm the\ud diagnosis. The medical treatment includes anthelmintics (mebendazole or\ud albendazole) and glucocorticosteroids.\ud A section is devoted to control measures, including a possible vaccine for which\ud several molecules are under investigation

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Imported Human Trichinellosis: Sequential IgG4 Antibody Response to Trichinella spiralis

Cited by 13 publications

References 10 publications

Proteomic analysis of the response of Trichinella spiralis muscle larvae to exogenous nitric oxide

Proteomic analysis of the response of Trichinella spiralis muscle larvae to exogenous nitric oxide

Trichinellosis

Trichinellosis

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