Impotence, Smoking, and β-Blocking Drugs

Forsberg, L.; Gustavii, Birgitta; Höjerback, Torvald; Olsson, Anders

doi:10.1016/s0015-0282(16)44007-0

Cited by 44 publications

(12 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…With the exception of diuretics, the data demonstrate moderate or no increase in risk among most antihypertensives, and this is consistent with previous studies. 1,2,[4][5][6][7][8][9]11,12 The fact that a protective effect was observed among diuretic users was quite unexpected and surprising, despite the use and acceptance of diuretics as a firstline treatment for hypertension. 14 Two factors influenced the decision to study ED in a diabetic cohort.…”

Section: Discussionmentioning

confidence: 99%

“…4,5 Subsequent peripheral vasoconstriction may lead to a decrease in genital blood flow, resulting in ED. We observed essentially no change in risk among beta blocker users (OR ¼ 1.05, 95% CI ¼ 0.85, 1.31).…”

Section: Discussionmentioning

confidence: 99%

“…[4][5][6][7][8] In TOMHS, the cardioselective beta blocker acebutolol did not result in a significant increase in ED compared with placebo. 1 However, decreased b 1 -receptor selectivity occurs with increasing dosages and may elicit ED.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Antihypertensive treatment and erectile dysfunction in a cohort of type II diabetes patients

2003

View full text Add to dashboard Cite

The association between different antihypertensive drugs and erectile dysfunction (ED) was examined in a cohort of type II diabetes patients identified in the UK General Practice Research Database (GPRD). The GPRD contains details of diagnoses, prescribing, investigations, risk factors, outcomes, and hospital referrals, together with basic demographic information for approximately six million patients from more than 450 representative general practices throughout the UK. A total of 634 cases and 2526 controls were included for analysis. Unconditional logistic regression analysis was performed to assess the risk of ED after adjusting for age at diabetes diagnosis date, cigarette smoking, depression, glycemic control, use of HMG-CoA reductase inhibitors, use of histamine receptor antagonists, use of digitalis medicines, and use of nitrates. Increased risk of ED was observed among patients taking the following antihypertensives: ACE inhibitors (OR ¼ 1.47, 95% CI ¼ 1.21, 1.80) and alpha blockers (OR ¼ 1.54, 95% CI ¼ 1.11, 2.12). However, we identified a nearly 30% reduction in risk among patients on diuretics (OR ¼ 0.73, 95% CI ¼ 0.54, 0.99). No statistically significant increase in risk was observed among users of beta blockers and calcium channel blockers (OR ¼ 1.05, 95% CI ¼ 0.85, 1.31) and (OR ¼ 1.14, 95% CI ¼ 0.91, 1.43), respectively. The results of this study confirm the strong and recognized effect of comorbidities in a diabetic population, but also require additional experimental and observational studies to further understand the potential benefit of diuretics and other ED treatments such as PDE5 inhibitors.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Antihypertensive treatment and erectile dysfunction in a cohort of type II diabetes patients

2003

View full text Add to dashboard Cite

show abstract

“…Medical records could not be assessed for tobacco use, a likely contributing determinant [21,22]. The patient level of education, thought to be a determinant in sexual dysfunction [4], was not assessed either, but this patient population generally has a relatively low education level.…”

Section: Discussionmentioning

confidence: 99%

Sexual Dysfunction in Male Psychiatric Outpatients: Validity of the Massachusetts General Hospital Sexual Functioning Questionnaire

Labbate

Lare²

2001

Psychother Psychosom

View full text Add to dashboard Cite

Background: The purpose of this study was to determine the frequency of sexual dysfunction in male outpatients with concomitant psychiatric and medical conditions and to establish the validity of the Massachusetts General Hospital Sexual Function Questionnaire (MGH). Methods: Male VA outpatients were given two sexual function questionnaires, a 36-item Changes in Sexual Functioning Questionnaire (CSFQ) and the 5-item MGH. Medical records were evaluated for diagnosis, medications and illnesses that might affect sexual functioning. Results: Among 100 outpatient respondents, the CSFQ showed that 90% and the MGH showed that 77% experienced sexual dysfunction. Forty percent of patients reported total absence of sexual function. Good concurrent validity was established between the MGH and CSFQ. Conclusions: Sexual dysfunction is highly prevalent in psychiatric outpatients. The MGH is a valid clinical measure to determine sexual dysfunction.

show abstract

“…thus is unclear whether sexual dysfunction is related to hypertension or its therapy [ 14], We found that a higher incidence of cavernous arterial insufficiency was noted in patients with a longer duration of diabetes, but there was no significant difference in cav ernous arterial insufficiency between the insulin-depen dent and nondependent groups. This prompts us to agree that vascular insufficiency is related to the duration of diabetes but not to the type of therapy [11], Cigarette smoking has been reported to cause impo tence due to its vasoconstrictive effect [15]. Eighteen of 21 patients (85.7%) who smoked cigarettes had cavernous arterial insufficiency.…”

Section: Discussionmentioning

confidence: 99%

Penile Blood Flow Study in Diabetic Impotence

Wang¹,

Shen

Wu³

et al. 1993

Urol Int

View full text Add to dashboard Cite

Seventy-eight male diabetics with sexual dysfunction were evaluated by a thorough history, general physical, psychological, neurological and urological examinations, routine laboratory tests, and a duplex ultrasound scan with intracavernous injection of prostaglandin E₁ (PGE₁). The mean patient age was 55.9 years, and the average onset of sexual dysfunction was 10.0 years after the diagnosis of diabetes. Sixty-eight patients (87.2%) had moderate or severe cavernous arterial insufficiency. Older patients and those having a longer duration of diabetes had a higher incidence of cavernous arterial insufficiency. Cigarette smoking, hypertension, and alcohol abuse were also related to cavernous arterial insufficiency. There was no significant difference in cavernous arterial insufficiency between the insulin-dependent and the insulin-nondependent groups. There were significant differences of diameters and peak blood flow velocities of cavernous arteries between 78 diabetic impotent patients and 10 controls. These findings strongly suggest that the cavernous arterial insufficiency is closely related to the diabetic impotence. In addition, the prevalence of cavernous arterial insufficiency increases with age, duration of diabetes, cigarette smoking, hypertension and alcohol abuse, but it is not definitely correlated with the type of diabetes management.

show abstract

Impotence, Smoking, and β-Blocking Drugs

Cited by 44 publications

References 4 publications

Antihypertensive treatment and erectile dysfunction in a cohort of type II diabetes patients

Antihypertensive treatment and erectile dysfunction in a cohort of type II diabetes patients

Sexual Dysfunction in Male Psychiatric Outpatients: Validity of the Massachusetts General Hospital Sexual Functioning Questionnaire

Penile Blood Flow Study in Diabetic Impotence

Contact Info

Product

Resources

About